Podcast 544: C is for Sepsis

Podcast 544: C is for Sepsis

Author: Aaron Lessen, MD

Educational Pearls:

  • Previously, trials had shown promising evidence that vitamin C may improve mortality rates in patients with sepsis or septic shock.
  • A 2017 retrospective before-after study gave a "cocktail" of hydrocortisone, vitamin C, and thiamine to patients with severe sepsis or in septic shock and reported a decrease in mortality from 40% to 8%.
  • A 2020 randomized controlled trial demonstrated that giving patients hydrocortisone, vitamin C, and thiamine showed no benefits in improving sepsis outcomes.
  • Currently use of Vitamin C in sepsis and septic shock remains controversial due to lack of sufficient data

References

1) Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest. 2017;151(6):1229. Epub 2016 Dec 6.

2) Fujii T, Luethi N, Young PJ, et al. Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial. JAMA. 2020;323(5):423–431. doi:10.1001/jama.2019.22176

Summarized by Jackson Roos, MS3 | Edited by Erik Verzemnieks, MD



Jaksot(1146)

Podcast #202: Tide Pods

Podcast #202: Tide Pods

Author: Susan Brion M.D. Educational Pearls: Laundry and dishwasher detergent pods resemble candy and can be ingested by children. These tide pods are very highly concentrated and can cause chemical ...

10 Touko 20173min

Podcast #201: Task Interruption

Podcast #201: Task Interruption

Author: Mark Kozlowski M.D. Educational Pearls: Humans cannot "multitask" effectively - a more accurate term is "task interruption." When doing more than one task at once, we are more likely to forge...

8 Touko 20173min

Podcast #200: Non-traumatic Back Pain

Podcast #200: Non-traumatic Back Pain

Author: Don Stader M.D. Educational Pearls: Non-traumatic back pain is a very common complaint in the Emergency Department. Conditions that can manifest with back pain include: ruptured abdominal aor...

6 Touko 20172min

Podcast #199: Prolonged QT with Zofran

Podcast #199: Prolonged QT with Zofran

Author: Arthur Lessen M.D. Educational Pearls: Zofran (ondansetron) is generally safe to use for the treatment of nausea and vomiting. However, it can prolong the QT interval and increase the chance ...

4 Touko 20173min

Podcast #198: Imodium

Podcast #198: Imodium

Author: Aaron Lessen M.D. Educational Pearls: Imodium (loperamide) is a mu-opioid receptor agonist. Traditionally, it is used as an anti-diarrheal. It is also abused recreationally for an opioid high...

2 Touko 20173min

Podcast #197: Ashman Phenomenon

Podcast #197: Ashman Phenomenon

Author: Dylan Luyten M.D. Educational Pearls: Ashman's Phenomenon occurs in the setting atrial fibrillation and mimics ventricular tachycardia, but is harmless. On ECG, the pattern of Ashman Phenomen...

30 Huhti 20171min

Podcast #196: DVT and May-Thurner Syndrome

Podcast #196: DVT and May-Thurner Syndrome

Author: Samuel Killian M.D. Educational Pearls: Lower extremity DVTs are extremely common. There are more left lower extremity DVT due to anatomical variation. May-Thurner Syndrome is a form of anato...

28 Huhti 20172min

Podcast #195: How to Properly Inject Heroin

Podcast #195: How to Properly Inject Heroin

Author: Don Stader, M.D Educational Pearls: It is important for providers to know how to use IV drugs properly so that they can instruct their patients on how to avoid injury. Heroin use is increasin...

26 Huhti 20177min

Suosittua kategoriassa Tiede

tiedekulma-podcast
rss-poliisin-mieli
rss-mita-tulisi-tietaa
docemilia
rss-duodecim-lehti
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita
utelias-mieli
radio-antro
rss-astetta-parempi-elama-podcast
rss-lapsuuden-rakentajat-podcast
rss-lihavuudesta-podcast
rss-sosiopodi