Podcast 554: Sleeping Away Alzheimer's

Podcast 554: Sleeping Away Alzheimer's

Contributor: Dave Rosenberg, MD

Educational Pearls:

  • White noise is all the surrounding sound frequencies mixed together that your brain tunes down so you don't get distracted while you're sleeping
  • Pink noise, or deep soothing noises, is the accentuated bass sounds like falling rain or waves crashing your brain keys into while sleeping.
  • Brain electrical waves during stage 4 sleep (the deepest of sleeps), cause sudden increases and decreases in cerebral blood flow allowing for CSF washing of the brain, which helps eliminate beta amyloid - the misfolded protein linked to Alzheimers
  • Pink noise during sleep has been shown to increase stage 4, creating more CSF washout of beta amyloid.

References

1. Spinedi, E. Cardinali, DP. Neuroendocrine Metabolic Dysfunction and Sleep Disturbances in Neurodegenerative Disorders: Focus on Alzhimer's Disease and Melatonin. Neuroendocrinology. 2019;108(4):354-364. doi: 10.1159/000494889. Epub 2018 Oct 28.

2. Zee, P. Papalambros NA. et al. Acoustic Enhancement of Sleep Slow Oscillations and Concomitant Memory Improvement in Older Adults. Front Hum Neurosci. 2017 Mar 8;11:109. doi: 10.3389/fnhum.2017.00109. eCollection 2017.

Summarized by Jackson Roos, MS3 | Edited by Erik Verzemnieks, MD



Jaksot(1146)

Podcast #279: Sedation After Intubation

Podcast #279: Sedation After Intubation

Author: Aaron Lessen, M.D. Educational Pearls Post-intubation care should always include pain control and adequate sedation. Commonly used sedation agents include propofol, ketamine and versed. Howev...

8 Joulu 20171min

Podcast #278: Subdural Hematomas

Podcast #278: Subdural Hematomas

Educational Pearls Subdural hematomas can happen in the elderly because of brain atrophy, and can manifest with neurological deficit. Subdural hematomas are caused by rupture of the bridging veins of...

6 Joulu 20172min

Podcast #277: Mucor

Podcast #277: Mucor

Author: Don Stader, M.D. Educational Pearls Mucor/Rhizopus fungal infections usually present in diabetic or immunocompromised patients as a black, necrotic lesion on the face. The fungus invades the ...

4 Joulu 20172min

Podcast #276: Angioedema

Podcast #276: Angioedema

Author: John Winkler, M.D. Educational Pearls Angioedema is immediately life-threatening due to airway obstruction. Mechanisms include allergic reaction (histamine-related) or bradykinin-related (ACE...

1 Joulu 20173min

Podcast #275: Battery Ingestions

Podcast #275: Battery Ingestions

Author: Nick Hatch, M.D. Educational Pearls Unlike coin ingestions, button batteries can cause necrosis of the GI tract. If lodged in the esophagus, removal within 2 hours is important, because they ...

29 Marras 20174min

Podcast #274: Pediatric Sedation

Podcast #274: Pediatric Sedation

Author: Aaron Lessen, M.D. Educational Pearls A recent prospective observational study was performed to examine the safety of different sedation medications in the pediatric ED. This study included 6...

27 Marras 20172min

Podcast #273:  Bag Valve Masks

Podcast #273: Bag Valve Masks

Author: Sam Killian, M.D. Educational Pearls Difficulty with bag valve mask (BVM) ventilation can be addressed using the MOANS mnemonic. Mask seal, Obesity/obstruction, Age, No teeth, Sleep apnea. O...

17 Marras 20173min

Podcast #272: More on Temperature in Sepsis

Podcast #272: More on Temperature in Sepsis

Author: David Rosenberg, M.D. Educational Pearls A study of 20,000 subjects found that reducing fever in sepsis did not improve outcomes such as morbidity, mortality, or length of stay. However, corr...

16 Marras 20172min

Suosittua kategoriassa Tiede

tiedekulma-podcast
rss-poliisin-mieli
rss-mita-tulisi-tietaa
docemilia
rss-duodecim-lehti
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita
utelias-mieli
radio-antro
rss-astetta-parempi-elama-podcast
rss-lapsuuden-rakentajat-podcast
rss-lihavuudesta-podcast
rss-sosiopodi