Podcast 601: Droperidol

Podcast 601: Droperidol

Contributor: Sam Killian, MD

Educational Pearls:

  • Droperidol (Inapsine) is an antipsychotic drug with efficacy for nausea, vomiting, headaches, and treating agitation
  • In the early 2000's, Droperidol received a black box warning for QT prolongation
  • This caused a precipitous drop of in administration and ultimately led to a stop in production
  • More careful analysis since has called into question the true incidence of QT prolongation in typical dosing
  • Retrospective review published this year looked at 15,374 non-critical and 1,172 critical patients who received droperidol with only a single episode of Torsades des pointes (which was attributed to multiple other risk factors)
  • Of the 2,431 non-critical patients, and 396 critical patients, who received an ECG before and after administration, there were no changes to the mean QTc
  • Droperidol is being manufactured again and the prior black box warning being called into question, so it will likely begin to become more widely available for use

References

Cole JB, Lee SC, Martel ML, Smith SW, Biros MH, Miner JR. The Incidence of QT Prolongation and Torsades des Pointes in Patients Receiving Droperidol in an Urban Emergency Department. West J Emerg Med. 2020 Jul 2;21(4):728-736. doi: 10.5811/westjem.2020.4.47036. PMID: 32726229; PMCID: PMC7390553.

Perkins J, Ho JD, Vilke GM, DeMers G. American Academy of Emergency Medicine Position Statement: Safety of Droperidol Use in the Emergency Department. J Emerg Med. 2015 Jul;49(1):91-7. doi: 10.1016/j.jemermed.2014.12.024. Epub 2015 Mar 30. PMID: 25837231.

Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD



Jaksot(1146)

Podcast 569:  The eFAST Exam

Podcast 569: The eFAST Exam

Contributor: Aaron Lessen, MD Educational Pearls:.   Focused assessment with Sonography for Trauma (FAST) exam and the extended-FAST (eFAST) are essential components of current trauma care and evalua...

8 Kesä 20202min

Podcast 568: Shock 'em!

Podcast 568: Shock 'em!

Contributor: John Winkler, MD Educational Pearls: Unstable ventricular tachycardia (VT) typically manifests with syncope, shortness of breath, diaphoresis and/or chest pain with hemodynamic instabili...

2 Kesä 20203min

Podcast 567:  Mechanical CPR….Not So Fast

Podcast 567: Mechanical CPR….Not So Fast

Contributor: Aaron Lessen, MD Educational Pearls: Mechanical CPR (machine assisted compression devices) remains a hot topic of debate in emergency medicine Machine assisted CPR has been advocated to ...

1 Kesä 20202min

Selected Audio from 'UnfilterED #7: Russell J. Ledet, Ph.D.'

Selected Audio from 'UnfilterED #7: Russell J. Ledet, Ph.D.'

"Go unafraid! And also know that you got to reach out to the right people and hold on to those people no matter what they look like, no matter what background they come from...Find people who are posi...

31 Touko 20205min

UnfilterED #7: Russell J. Ledet, Ph.D.

UnfilterED #7: Russell J. Ledet, Ph.D.

Russell J. Ledet hails from Lake Charles, Louisiana. After serving in the U.S. Navy, he attended Southern University and A&M College for his undergraduate degrees in biology and chemistry. Afterwards,...

27 Touko 202058min

Podcast 566:  The Cholera Pandemic

Podcast 566: The Cholera Pandemic

Contributor: Jared Scott, MD Educational Pearls: Cholera has been responsible for 6 previous global pandemics and currently the world is in the seventh pandemic of cholera, ongoing since 1961. Choler...

26 Touko 20204min

Podcast 565: Cesarean Scar Pregnancies

Podcast 565: Cesarean Scar Pregnancies

Contributor: Nick Hatch, MD Educational Pearls: A cesarean scar ectopic pregnancy occurs when the pregnancy implants along the scar tissue deep in the myometrium from a prior cesarean surgery, felt t...

25 Touko 20203min

COVID-19 Digest: The Possible Link Between Severe COVID-19 and Low Vitamin D Levels (Recorded 5/21/20)

COVID-19 Digest: The Possible Link Between Severe COVID-19 and Low Vitamin D Levels (Recorded 5/21/20)

Host: Elizabeth Esty, MD. At this point, with so many of the studies we've digested exploring correlations, associations, observational studies and anecdotal reports and speculation, we could subtitle...

22 Touko 202018min

Suosittua kategoriassa Tiede

rss-poliisin-mieli
rss-mita-tulisi-tietaa
tiedekulma-podcast
docemilia
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita
rss-duodecim-lehti
radio-antro
utelias-mieli
filocast-filosofian-perusteet
rss-lapsuuden-rakentajat-podcast
rss-lihavuudesta-podcast
rss-sosiopodi