Pharmacy Phriday #7: Bactrim Adverse Events

Pharmacy Phriday #7: Bactrim Adverse Events

Contributor: Cheyenne Bean, PharmD

Educational Pearls:

  • Bactrim (TMP-SMX) is a sulfa antibiotic used for a number of infections but can have untoward effects.
  • Hypoglycemia can be induced by the sulfa component of Bactrim, which binds receptors in the pancreas causing insulin to be secreted, dropping blood sugar levels.
    • Oral diabetic medications, specifically sulfonylureas, when taken with Bactrim most often lead to these hypoglycemic episodes.
  • Hyperkalemia can be induced by Trimethoprim by blocking potassium excretion in the kidney, so Bactrim in combination with ACE inhibitors/ARBs/spironolactone can induce high potassium.
  • When prescribing Bactrim, remember to check home medications and if a patient is taking an above medication, check a baseline BGL and potassium.

References

1) Khorvash F, Moeinzadeh F, Saffaei A, Hakamifard A. Trimethoprim-sulfamethoxazole Induced Hyponatremia and Hyperkalemia, The Necessity of Electrolyte Follow-up in Every Patient. Iran J Kidney Dis. 2019 Jul;13(4):277-280. PMID: 31422395.

2) Kennedy KE, Teng C, Patek TM, Frei CR. Hypoglycemia Associated with Antibiotics Alone and in Combination with Sulfonylureas and Meglitinides: An Epidemiologic Surveillance Study of the FDA Adverse Event Reporting System (FAERS). Drug Saf. 2020 Apr;43(4):363-369. doi: 10.1007/s40264-019-00901-7. PMID: 31863282; PMCID: PMC7117991.

Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD

The Emergency Medical Minute is excited to announce that we are now offering AMA PRA Category 1 credits™ via online course modules. To access these and for more information, visit our website at www.emergencymedicalminute.com/cme-courses/ and create an account.

Jaksot(1146)

Husband & Wife, Both ER Clinicians, Share Their Experience Having COVID-19

Husband & Wife, Both ER Clinicians, Share Their Experience Having COVID-19

Long time friends of EMM, Aaron and Bree, share their experiences on the frontlines in the ED, coping with COVID, managing anxiety and quarantining with their family.

1 Huhti 202036min

COVID-19 Digest: Do NSAIDs Make COVID-19 More Severe? (Recorded 3/30/20, 18:00 MST)

COVID-19 Digest: Do NSAIDs Make COVID-19 More Severe? (Recorded 3/30/20, 18:00 MST)

In the past two weeks, warnings, questions, and misinformation concerning COVID-19 and NSAID use have been spreading...no pun intended..virally. The pace of this evolving pandemic and the equally quic...

31 Maalis 202018min

Podcast 552: PE Management and Risk Stratification

Podcast 552: PE Management and Risk Stratification

Contributor: Dylan Luyten, MD Educational Pearls: After you diagnose a pulmonary embolism (PE) via CT or VQ scan, we need to categorize the PE as massive, sub-massive, or just PE to dictate treatment...

30 Maalis 20209min

COVID-19 Digest: If You've Had COVID-19, Can You Get it Again? / Convalescent Serum (Recorded 3/26/20, 18:00 MST)

COVID-19 Digest: If You've Had COVID-19, Can You Get it Again? / Convalescent Serum (Recorded 3/26/20, 18:00 MST)

Host: Elizabeth Esty, MD Research By: Elizabeth Esty and Nathan Novotny References: Osumi M. Questions raised over COVID-19 reinfection after Japanese woman develops illness again. The Japan Times. h...

27 Maalis 202010min

ER Doc Infected with COVID-19 Shares Experience

ER Doc Infected with COVID-19 Shares Experience

Recorded 3/26/20

27 Maalis 202020min

COVID-19: Hydroxychloroquine & Azithromycin / Anosmia / The Aerosolized vs. Droplet Debate (Recorded 3/24/20, 18:00 MST)

COVID-19: Hydroxychloroquine & Azithromycin / Anosmia / The Aerosolized vs. Droplet Debate (Recorded 3/24/20, 18:00 MST)

The circumstances surrounding the COVID-19 virus are quickly evolving and that means that EMM will have to as well. For the foreseeable future, EMM will be releasing COVID-19 updates. In this series, ...

25 Maalis 202015min

Podcast 551:  PPIs are Not Benign

Podcast 551: PPIs are Not Benign

Contributor: Don Stader, MD Educational Pearls: PPIs (Proton pump inhibitors) reduce stomach acid levels and are commonly prescribed in patients with GERD or peptic ulcer disease Stopping a PPI after...

23 Maalis 20203min

On the Streets #3: COVID-19

On the Streets #3: COVID-19

In this special edition of our On the Streets podcast, we discuss COVID-19 as well as what first responders and emergency providers need to know to keep themselves and their patients safe during this ...

19 Maalis 202020min

Suosittua kategoriassa Tiede

tiedekulma-podcast
rss-poliisin-mieli
rss-mita-tulisi-tietaa
docemilia
rss-duodecim-lehti
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita
utelias-mieli
radio-antro
rss-astetta-parempi-elama-podcast
rss-lapsuuden-rakentajat-podcast
rss-lihavuudesta-podcast
rss-sosiopodi