Podcast 637: LSD

Podcast 637: LSD

Contributor: Katie Sprinkel, MD

Educational Pearls:

  • Commonly known as "acid," LSD is seeing a resurgence in the population as a recreational hallucination
  • Onset is about 30 minutes with peak pharmacologic effects at 2-4 hours, the drug's half life is 3 hours resulting in some prolonged effects
  • While there is not an significant addictive component of LSD, tolerance for LSD does occur and prolonged usage is associated with increased incidence of schizophreniform disorders
  • Hallucinations and pseudo-hallucinations (sensory misperceptions) are typical of LSD intoxication, other common signs of intoxication include nausea, diaphoresis, tachycardia, mydriasis, and hypertension
  • More serious effects can be coma, hyperthermia, seizures, cardiac arrest, serotonin syndrome (with concomitant SSRI use) and coagulopathy, although the dose to cause these effects is very high
  • Treatment is decreasing sensory stimulation, benzodiazepines in some cases, and symptomatic treatment - no specific antidote exists

References

Blaho K, Merigian K, Winbery S, Geraci SA, Smartt C. Clinical pharmacology of lysergic acid diethylamide: case reports and review of the treatment of intoxication. Am J Ther. 1997 May-Jun;4(5-6):211-21. doi: 10.1097/00045391-199705000-00008. PMID: 10423613.

Klock JC, Boerner U, Becker CE. Coma, hyperthermia and bleeding associated with massive LSD overdose. A report of eight cases. West J Med. 1974;120(3):183-188.

Summarized by John Spartz, MS3 | Edited by Erik Verzemnieks, MD



Jaksot(1147)

Podcast 789: DOAC

Podcast 789: DOAC

Contributor: Aaron Lessen, MD Educational Pearls: Direct Oral Anticoagulants (DOACs) have surpassed Warfarin and Lovenox® for anticoagulation as they do not require injection and allow for easier di...

13 Kesä 20223min

Mental Health Monthly #13: Substance-Induced Psychosis (Part I)

Mental Health Monthly #13: Substance-Induced Psychosis (Part I)

Substance-Induced Psychosis (Part I) In this first episode of a two-part mini-series, we feature Dr. Nadia Haddad, a Colorado psychiatrist, and Dr. Ricky Dhaliwal, an emergency medicine physician, a...

8 Kesä 202216min

Podcast 788: Tracheostomy Bleeding

Podcast 788: Tracheostomy Bleeding

Contributor: Aaron Lessen, MD Educational Pearls: Tracheostomy bleeding is a rare but potentially life-threatening complication that usually occurs within the first month of tracheostomy tube placeme...

7 Kesä 20225min

Podcast 787: TAVR and Stroke

Podcast 787: TAVR and Stroke

Contributor: Nick Hatch, MD Educational Pearls: Transcatheter aortic valve replacement (TAVR) is an increasingly common endovascular procedure to treat aortic stenosis TAVR is an alternative to the o...

6 Kesä 20224min

Podcast 786: Smiling Death

Podcast 786: Smiling Death

Contributor: Nick Hatch, MD Educational Pearls: "Smiling Death" describes the prehospital phenomenon of a person who is happy to be extricated from an extended period of crush injury, but dies sudden...

31 Touko 20226min

Podcast 785: Pepper Spray

Podcast 785: Pepper Spray

Contributor: Jared Scott, MD Educational Pearls: Pepper spray is a chemical irritant derived from oleoresin capsicum (OC), an extract from pepper plants. It can be used by police for riot or crowd co...

30 Touko 20226min

Podcast 784: Wastewater Surveillance for COVID

Podcast 784: Wastewater Surveillance for COVID

Contributor: Jared Scott, MD Educational Pearls: About 50% of those infected with SARS-CoV-2 will shed the virus in their feces Wastewater surveillance can be used to track COVID burden, which may ...

24 Touko 20225min

Podcast 783: LAD Occlusion & Troponin

Podcast 783: LAD Occlusion & Troponin

Contributor: Jared Scott, MD Educational Pearls: A study randomized 34 healthy patient to have their left anterior descending artery (LAD) occluded by balloon for 0, 15, 30, or 90 seconds Subsequen...

23 Touko 20225min

Suosittua kategoriassa Tiede

rss-mita-tulisi-tietaa
rss-poliisin-mieli
utelias-mieli
tiedekulma-podcast
docemilia
rss-duodecim-lehti
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita
filocast-filosofian-perusteet
rss-tervetta-skeptisyytta