Podcast 732: Organophosphate Toxicity

Podcast 732: Organophosphate Toxicity

Educational Pearls:

  • Organophosphates affect the cholinergic system by inhibiting acetylcholinesterase affecting muscarinic and nicotinic receptors
  • Symptoms include lacrimation, salivation, bronchoconstriction, blurred vision, bradycardia, bronchorrhea, emesis, and diarrhea
  • Initially, the patient should be decontaminated to prevent further organophosphate exposure
  • Treatment consists of atropine every 5 minutes, 1-3 mg to start and doubling the dose each time it is given until reversal of symptoms is seen
  • Atropine only works on muscarinic receptors, so nicotinic receptor activation continues despite atropine administration resulting in muscle contractions and eventually respiratory arrest
  • Pralidoxime (2-PAM) should also be given to prevent the nicotinic effects and maturation of the organophosphate-acetylcholinesterase complex

References

Robb EL, Baker MB. Organophosphate Toxicity. [Updated 2021 Jul 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470430/

Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD

*********************

The Emergency Medical Minute is excited to announce that we are now offering AMA PRA Category 1 credits™ via online course modules. To access these and for more information, visit our website at https://emergencymedicalminute.org/cme-courses/ and create an account.

Donate to EMM today!

Diversity and Inclusion Award



Jaksot(1145)

Podcast #227: CPR-Induced Consciousness

Podcast #227: CPR-Induced Consciousness

Author: Nick Hatch, M.D. Educational Pearls CPR-induced consciousness is a phenomenon that occurs when someone who was previously unconscious and is undergoing CPR regains consciousness and makes pur...

20 Heinä 20173min

Podcast #226: Biphasic Anaphylaxis

Podcast #226: Biphasic Anaphylaxis

Author: Sam Killian, M.D. Educational Pearls Anaphylaxis is common in the ED. These patients are treated and then usually watched for 4-6 hours. Biphasic happens in patients that have a complete reso...

18 Heinä 20173min

Podcast #225: Rhogam

Podcast #225: Rhogam

Author: Dylan Luyten, M.D. Educational Pearls Rhogam is commonly used when an Rh negative woman has an Rh positive fetus. It is commonly used in the ER in the setting of a miscarriage. Rh(+) fetal bl...

16 Heinä 20174min

Deep Dive #4: Pediatric Type I DKA

Deep Dive #4: Pediatric Type I DKA

Author: Justin Harper Justin Harper, a paramedic married to a pediatric nurse, discovered his own son had type I diabetes 2 years ago. Despite their medical experience, this diagnosis came as surprise...

14 Heinä 201747min

Brewcast Part VIII: Cannabis in Colorado

Brewcast Part VIII: Cannabis in Colorado

Author: Dr. Larry Wolk, Executive Director and Chief Medical Officer for the Colorado Department of Public Health and Environment. Topic: Dr. Larry Wolk educates us on how cannabis has affected Colora...

9 Heinä 201717min

Brewcast Part VII: A Patient's Perspective on Medical Marijuana

Brewcast Part VII: A Patient's Perspective on Medical Marijuana

Authors: Don Stader, M.D. & Lauren Gibbs Topic: Lauren breaks the stoner stereotype and explains how marijuana has positively impacted her life.

8 Heinä 201720min

Brewcast Part VI: Synthetic Marijuana

Brewcast Part VI: Synthetic Marijuana

Author: Erik Verzemnieks, M.D. Topic: Erik speaks about how slightly altering the chemical composition of marijuana can create a drug with drastic effects on the human body. WARNING: Explicit Language

7 Heinä 201712min

Brewcast Part V: Researching Cannabis

Brewcast Part V: Researching Cannabis

Author: Sophie Yorkwilliams -B.A. (Psychology) -Dual Ph.D. Candidate, Clinical Psychology and Neuroscience. Expected graduation: 2020 Topic: Studying cannabis comes with its own set of challenges. Fin...

6 Heinä 201717min

Suosittua kategoriassa Tiede

tiedekulma-podcast
rss-mita-tulisi-tietaa
rss-poliisin-mieli
rss-duodecim-lehti
docemilia
radio-antro
filocast-filosofian-perusteet
rss-ammamafia
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita
rss-sosiopodi
utelias-mieli
rss-astetta-parempi-elama-podcast
rss-tiedetta-vai-tarinaa