Podcast 777: Grass, Weed, and Ancient Rome

Podcast 777: Grass, Weed, and Ancient Rome

Contributor: Chris Holmes, MD

Educational Pearls:

  • Antiemetics were used in ancient Rome to help with sea-sickness and included toxic substances such as wine and wormwood and white hellborn
  • The first antihistamine used for nausea, dramamine, was introduced in 1947 for motion sickness
  • After this chlorpromazine, prochlorperazine, and promethazine came about in the 1950s and 1960s
  • Cannabis, colloquially referred to as weed, isolates like THC used in the 1970s to help with chemotherapy-induced
  • After this in the 1980s, ondansetron and metoclopramide were introduced for more severe chemotherapy-induced nausea
  • Lastly, NK-1 inhibitors were introduced to treat nausea

References

Sanger GJ, Andrews PLR. A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research. Front Pharmacol. 2018;9:913. Published 2018 Sep 4. doi:10.3389/fphar.2018.00913

Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD

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Episode 913: Vasopressors after ROSC

Episode 913: Vasopressors after ROSC

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Episode 911: Anticholinergic Toxicity

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Episode 910: Cellulitis Recovery Timeline

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Episode 909: Prehospital Blood Pressure Management in Suspected Stroke

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Episode 908: Sympathomimetic Drugs

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Episode 907: Wide-Complex Tachycardia

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Episode 906: Case Study of Hypernatremia

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