Episode 905: Oseltamivir (Tamiflu) for Influenza

Episode 905: Oseltamivir (Tamiflu) for Influenza

Contributor: Aaron Lessem MD

Educational Pearls:

  • Oseltamivir (Tamiflu) is an antiviral medication used commonly to treat influenza

  • Trials show that the medication reduces the duration of illness by less than 1 day (~16 hours in one systematic review)

    • Benefit only occurs if taken within 48 hours of symptom onset

    • Must be taken for 5 days

  • A 2024 meta-analysis reviewed 15 randomized-controlled trials for the risk of hospitalization

    • No reduction in hospitalizations with oseltamivir in patients over the age of 12

    • No difference in high-risk patients over the age of 65 or those with comorbidities

      • The authors note that the confidence interval in these populations is wide, indicating a need for subsequent studies in high-risk populations

  • Oseltamivir is associated with adverse effects including nausea, vomiting, and neurologic symptoms

    • The risk of adverse effects may outweigh the benefits of a small reduction in the duration of illness

References

1. Hanula R, Bortolussi-Courval É, Mendel A, Ward BJ, Lee TC, McDonald EG. Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients with Influenza: A Systematic Review and Meta-Analysis. JAMA Intern Med. 2024;184(1):18-27. doi:10.1001/jamainternmed.2023.0699

2. Jefferson T, Jones M, Doshi P, Spencer EA, Onakpoya I, Heneghan CJ. Oseltamivir for influenza in adults and children: Systematic review of clinical study reports and summary of regulatory comments. BMJ. 2014;348(April):1-18. doi:10.1136/bmj.g2545

Summarized by Jorge Chalit, OMSII | Edited by Meg Joyce & Jorge Chalit

Jaksot(1145)

Podcast #193: The Quick Wee

Podcast #193: The Quick Wee

Author: JP Brewer M.D. Educational Pearls: The "Quick Wee" was a method to get urine out of infants who need to have a UA in the Emergency Department. A randomized-controlled experiment was done with...

22 Huhti 20172min

Podcast #192: Back Fat Hernia

Podcast #192: Back Fat Hernia

Author: Jared Scott M.D. Educational Pearls: There are two anatomical triangles on the back, the inferior lumbar triangle and the superior lumbar triangle. Herniation occurs whenever something moves ...

20 Huhti 20173min

Podcast #191: Blunt Cervical Trauma

Podcast #191: Blunt Cervical Trauma

Author: Chris Holmes M.D. Educational Pearls: Mechanism of injury involves hyperextension/hyperflexion Pathophysiology: inside of the arteries in the neck becomes disrupted, similar to a dissection. ...

18 Huhti 20172min

Deep Dive #2: Biological Terrorism

Deep Dive #2: Biological Terrorism

Author: Michael Hunt M.D. Dr. Hunt shares his wealth of experience with biological terrorism over the course of his career.

16 Huhti 201728min

Podcast #190: Toradol Dosing

Podcast #190: Toradol Dosing

Author: Rachel Duncan, PharmD BCPS Educational Pearls: Toradol (Ketorolac) is an NSAID used for its anti-inflammatory properties In practice, the common dosages are 30mg IV or 60mg IM. Clinical conce...

14 Huhti 20172min

Podcast #189: Caffeine

Podcast #189: Caffeine

Author: Donald Stader M.D. Educational Pearls: Coffee originates from Ethiopia. Its "active ingredient" is caffeine. Caffeine is a xanthine alkaloid used in medicine to control headache and as a neo...

12 Huhti 20173min

Podcast #188: Monoarthritis

Podcast #188: Monoarthritis

Author: Peter Bakes M.D. Educational Pearls: Some common causes of monoarticular arthritis include: crystal arthropathies (gout and pseudogout), infection (septic joint), reactive arthritis and acute...

10 Huhti 20175min

Podcast #187: Mumps

Podcast #187: Mumps

Author: Gretchen Hinson M.D. Educational Pearls: The key imaging of a mumps patient is "chipmunk cheeks" or parotitis. The swelling can extend almost to the ears and can be extremely painful - in abo...

29 Maalis 20174min

Suosittua kategoriassa Tiede

tiedekulma-podcast
rss-mita-tulisi-tietaa
rss-poliisin-mieli
docemilia
radio-antro
utelias-mieli
filocast-filosofian-perusteet
rss-sosiopodi
ihanat-ipanat
mielipaivakirja
rss-bios-podcast
rss-duodecim-lehti
rss-ammamafia
rss-laakaripodi
rss-opeklubi