Episode 905: Oseltamivir (Tamiflu) for Influenza

Episode 905: Oseltamivir (Tamiflu) for Influenza

Contributor: Aaron Lessem MD

Educational Pearls:

  • Oseltamivir (Tamiflu) is an antiviral medication used commonly to treat influenza

  • Trials show that the medication reduces the duration of illness by less than 1 day (~16 hours in one systematic review)

    • Benefit only occurs if taken within 48 hours of symptom onset

    • Must be taken for 5 days

  • A 2024 meta-analysis reviewed 15 randomized-controlled trials for the risk of hospitalization

    • No reduction in hospitalizations with oseltamivir in patients over the age of 12

    • No difference in high-risk patients over the age of 65 or those with comorbidities

      • The authors note that the confidence interval in these populations is wide, indicating a need for subsequent studies in high-risk populations

  • Oseltamivir is associated with adverse effects including nausea, vomiting, and neurologic symptoms

    • The risk of adverse effects may outweigh the benefits of a small reduction in the duration of illness

References

1. Hanula R, Bortolussi-Courval É, Mendel A, Ward BJ, Lee TC, McDonald EG. Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients with Influenza: A Systematic Review and Meta-Analysis. JAMA Intern Med. 2024;184(1):18-27. doi:10.1001/jamainternmed.2023.0699

2. Jefferson T, Jones M, Doshi P, Spencer EA, Onakpoya I, Heneghan CJ. Oseltamivir for influenza in adults and children: Systematic review of clinical study reports and summary of regulatory comments. BMJ. 2014;348(April):1-18. doi:10.1136/bmj.g2545

Summarized by Jorge Chalit, OMSII | Edited by Meg Joyce & Jorge Chalit

Jaksot(1146)

UnfilterED #6: Dr. Anton Helman

UnfilterED #6: Dr. Anton Helman

In this organic conversation, Nick and Dr. Helman establish a warm rapport early on as they discuss musical beginnings, life-changing mentors and the origins of Emergency Medicine Cases. Their banter ...

22 Huhti 202039min

COVID-19 Digest: Airborne Transmission / Remdesivir (Recorded 4/14/20)

COVID-19 Digest: Airborne Transmission / Remdesivir (Recorded 4/14/20)

In this episode of the COVID-19 Digest, we revisit the airborne vs droplet transmission debate and analyze a highly publicized study on Remdesivir from the New England Journal of Medicine. Host: Eliz...

15 Huhti 202012min

On the Streets #4: Posterior Circulation Strokes

On the Streets #4: Posterior Circulation Strokes

In part 2 of our interview with Dr. Adam Graham, Jordan takes a deep dive into posterior circulation strokes and how to identify them in the field.

14 Huhti 202017min

Podcast 554: Sleeping Away Alzheimer's

Podcast 554: Sleeping Away Alzheimer's

Contributor: Dave Rosenberg, MD Educational Pearls: White noise is all the surrounding sound frequencies mixed together that your brain tunes down so you don't get distracted while you're sleeping Pi...

13 Huhti 20202min

COVID-19: Behind the Masks

COVID-19: Behind the Masks

The circumstances that led to the national shortage in PPE for healthcare workers, the inspiring work of New Orleans med students to equip medical providers with PPE and the science behind personal us...

9 Huhti 202022min

Podcast 553: Airway Management in the Hypoxic COVID-19 Patient (Recorded 4/3/20)

Podcast 553: Airway Management in the Hypoxic COVID-19 Patient (Recorded 4/3/20)

Contributor: Dylan Luyten, MD Educational pearls: Clinical management of COVID-19 is rapidly evolving, relying on case reports and clinical experience In just a month, the consensus around management...

6 Huhti 20208min

COVID-19 Digest: Hydroxychloroquine Update (Recorded 4/3/20)

COVID-19 Digest: Hydroxychloroquine Update (Recorded 4/3/20)

In our coverage of COVID-19 this week, we've investigated the shakey evidence for NSAID use making COVID worse, heard first-hand accounts from ED clinicians with COVID, and looked at the status of tes...

4 Huhti 20209min

COVID-19 in the United States: Where are the tests?

COVID-19 in the United States: Where are the tests?

A dive into how the United States responded to an emerging pandemic and the pitfalls along the way that led to stalled testing capacity across the country before community transmission was confirmed. ...

2 Huhti 202010min

Suosittua kategoriassa Tiede

tiedekulma-podcast
rss-poliisin-mieli
rss-mita-tulisi-tietaa
docemilia
rss-duodecim-lehti
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita
utelias-mieli
radio-antro
rss-astetta-parempi-elama-podcast
rss-lapsuuden-rakentajat-podcast
rss-lihavuudesta-podcast
rss-sosiopodi