Journal Club: A New Path to Antibiotic Resistance
The a16z Show19 Heinä 2020

Journal Club: A New Path to Antibiotic Resistance

Ever since the discovery of antibiotics, microbiologists have worried about and studied how bacteria acquire resistance to these drugs. Adding to the complexity of this problem is the fact that it is not always clear whether the conditions that drive the evolution of resistance in the lab occur in patients suffering from bacterial infections.

This is where the work of Nathalie Balaban -- Professor at the Hebrew University, and our guest on this episode -- comes in. The article we discuss is based on a foundation of research done in her laboratory, but this study makes the important step into the clinic by using samples from a patient with a life-threatening bacterial (MRSA) infection. By analyzing these patient samples, Dr. Balaban and her team were able to understand the conditions that lead to multi-drug resistance in a hospital setting. The work reveals how the ability of bacteria to enter a state of dormancy, also known as tolerance, can act as a stepping stone to resistance and can interfere with the efficacy of drug combinations. Our conversation covers what tolerance is, the conditions that promote tolerance, how it can lead to resistance and impact drug combination therapies, and lastly, integrating this new understanding into clinical microbiology protocols.

"Effect of tolerance on the evolution of antibiotic resistance under drug combinations" in Science (January 2020) by Jiafeng Liu, Orit Gefen, Irine Ronin, Maskit Bar-Meir, Nathalie Q. Balaban.

a16z bio Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and why they matter from our perspective at the intersection of biology & technology (for bio journal club). You can find all these episodes at a16z.com/journalclub.

Stay Updated:

Find a16z on YouTube: YouTube

Find a16z on X

Find a16z on LinkedIn

Listen to the a16z Show on Spotify

Listen to the a16z Show on Apple Podcasts

Follow our host: https://twitter.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Jaksot(1000)

Novel Coronavirus Updates: How Healthcare System, Tests Work; More

Novel Coronavirus Updates: How Healthcare System, Tests Work; More

This episode covers the following -- since our previous deep-dive on the novel coronavirus outbreak -- including:practical implications for the U.S. healthcare system given how it works today, and whe...

27 Helmi 202021min

Metrics and Mindsets for Retention & Engagement

Metrics and Mindsets for Retention & Engagement

It's "Marketplaces Week" for us at a16z, thanks to our consumer team releasing a new index of the next industry-defining marketplaces, the Marketplace 100.  But what happens as such marketplaces and o...

20 Helmi 202033min

Tough Love, Global Diplomacy, and Lessons on Leadership

Tough Love, Global Diplomacy, and Lessons on Leadership

Susan shares how she learned to leverage the characteristics of her personality early in her career as assistant secretary of state [2:05]One of the important conversations Susan had with a mentor tha...

14 Helmi 202050min

Building the First CAR T Company

Building the First CAR T Company

with @OzAzamTmunity1, @JorgeCondeBio, and @omnivorousreadCAR T therapy, the groundbreaking new medicines that uses engineered T-cells to attack cancer, has been so effective in childhood leukemias tha...

7 Helmi 202028min

Rebel Talent

Rebel Talent

When we think about rebellious behavior in the context of organizations and companies, we tend to think of rebels as trouble-makers, rabble-rousers; in other words, people who make decisions and proce...

4 Helmi 202033min

All about the Coronavirus

All about the Coronavirus

This episode of 16 Minutes on the news from a16z is all about the recent coronavirus outbreak -- or rather, a new type of coronavirus called 2019-nCoV for 2019 novel coronavirus. Since it's an ongoing...

30 Tammi 202019min

The Truth about 1000 True Fans + Pricing Our Attention

The Truth about 1000 True Fans + Pricing Our Attention

The idea of "1000 true fans" -- first proposed by Kevin Kelly in 2008 and later updated for Tools of Titans -- argued that to be a successful creator, you don’t need millions of customers or clients, ...

27 Tammi 202015min

Writers Writing, Readers Reading, Creators Creating

Writers Writing, Readers Reading, Creators Creating

We've been financing good writing with bad advertising -- and "attention monsters" (to quote Craig Mod) for way too long. So what happens when the technology for creators finally falls into place? We'...

27 Tammi 202040min

Suosittua kategoriassa Liike-elämä ja talous

sijotuskasti
mimmit-sijoittaa
rss-rahapodi
psykopodiaa-podcast
rss-rahamania
rss-sisalto-kuntoon
ostan-asuntoja-podcast
rss-lahtijat
hyva-paha-johtaminen
rss-startup-ministerio
rss-sami-miettinen-neuvottelija
rss-seuraava-potilas
lakicast
herrasmieshakkerit
leadcast
rahapuhetta
rss-porssipuhetta
rss-rentotapaus
rss-tyoelamasta-podcast
rss-viisas-raha-podi