Degrading Drugs for Problem Proteins: Journal Club now on Bio Eats World (ep 2)
a16z Podcast27 Syys 2020

Degrading Drugs for Problem Proteins: Journal Club now on Bio Eats World (ep 2)

Welcome to the second episode of Bio Eats World, a brand new podcast all about how biology is technology. Bio is breaking out of the lab and clinic and into our daily lives -- on the verge of revolutionizing our world in ways we are only just beginning to imagine.

Many diseases are caused by proteins that have gone haywire in some fashion. There could be too much of the protein, it could be mutated, or it could be present in the wrong place or time. So how do you get rid of these problematic proteins? In this episode of Journal Club (now on Bio Eats World), Stanford professor Carolyn Bertozzi and host Lauren Richardson discuss the article “Lysosome-targeting chimaeras for degradation of extracellular proteins” by Steven Banik, Kayvon Pedram, Simon Wisnovsky, Green Ahn, Nicholas Riley, and Carolyn Bertozzi, published in Nature (2020).

Dr. Bertozzi and her lab developed a class of drugs — or modality — that tosses the disease-related proteins into the cellular trash can. While there are other drugs that work through targeted protein degradation, these drugs called LYTACs are able to attack a set of critical proteins, some of which have never been touched by any kind of drug before. The conversation covers how they engineered these new drugs, their benefits, and how they can be further optimized and specialized in the future.

Jaksot(911)

Learning from Open Source Communities

Learning from Open Source Communities

What can we learn from the evolution of open source communities and how might they be applied to online communities and the creator economy today? Author Nadia Asparouhova joins host Sonal Choksi to talk about Asparouhova's book, Working in Public: The Making and Maintenance of Open Source Software, from Stripe Press.They start with a  a taxonomy for communities, and then dig into how open source has changed over time, which learnings from open source do and don’t apply to new communities online, how communities intersect with the growing desire for more "high-shared context" groups and spaces (including even podcasts and newsletters), and more.

11 Elo 202247min

The Art and Science of Moderating Discussions

The Art and Science of Moderating Discussions

Whether it’s moderating a live panel discussion, managing your (virtual) All Hands meeting, or even guiding a cross-functional team to a decision in an important meeting, mastering the art of helping a group communicate is a critical skill for many of us.In this episode from November 2020, expert communications and presentations coach Matt Abrahams, who is also a lecturer at Stanford’s Graduate School of Business, sits down with Sonal Choksi to share frameworks, strategies and many concrete tips for how anyone can become a better moderator and facilitator. They cover everything from how to approach prep work (like, can you be too prepared?) and how to handle disruptions on the fly to the subtle differences between in-person and virtual events, the ways our own ticks can manifest before an audience, and more.

4 Elo 20221h 3min

Tiktok's Algorithm and Creativity Network Effects

Tiktok's Algorithm and Creativity Network Effects

What does the success of TikTok's algorithmically-driven product tell us about the future of creators and the creator economy, product design, and innovation within video?In this cross-over archive episode from our tech news podcast, 16 Minutes on the News, we go deep into the what, why, and how of TikTok's algorithm, which lies at the heart of the product and drives its "creativity network effects." The conversation features Eugene Wei (former head of product at Hulu, Flipboard, and video at Oculus), in conversation with host Sonal Choksi. This episode originally aired in September 2020, when there was talk of U.S. ownership/partnership for the American version of TikTok, which is from Chinese company ByteDance.

27 Heinä 202238min

From Research to Startup, There and Back Again

From Research to Startup, There and Back Again

In this episode from December 2018, Hennessy, currently the chairman of Alphabet as well as Turing Award-winning computer scientist, joins a16z co-founder Marc Andreessen, a16z general partner Martin Casado, and host Sonal Choksi for a wide-ranging conversation about moving from academia to startups, the history of Silicon Valley, the “Stanford model”, how to build enduring organizations, and more.Hennessy also co-founded startups, including one based on pioneering microprocessor architecture used in 99% of devices today (for which he and his collaborator won the prestigious Turing Award)... so what did it take to go from research/idea to industry/implementation? And  how has the overall relationship and "divide" between academia and industry shifted, especially as the tech industry itself has changed? Finally, in his book, Leading Matters, Hennessy shares some of the leadership principles he's learned, offering nuanced takes on topics like humility (needs ambition), empathy (without contravening fairness and reason), and others. What does it take to build not just tech, but a successful organization?

21 Heinä 202255min

Crisis Communications 101

Crisis Communications 101

In this hallway-style conversation with a16z's Margit Wennmachers, longtime operating partner for Marketing, and Kim Milosevich, CMO for a16z crypto, open up the black box of crisis communications with Sonal Choksi and explore the process and mindsets before, during, and after a crisis.They discuss common FAQs like: What constitutes a crisis? Can someone inside a company "call it" early and prevent a crisis from becoming a bigger deal? How do you respond when there's a lag or too much time between acknowledging the issue and finding out all the facts? Who should be in the (war) room ? Should you share the off-the-record background story with reporters? How do you know when a crisis begins and ends -- or that you're ready for a "comeback" story? We explore all this and more.

13 Heinä 202234min

All About Synthetic Biology

All About Synthetic Biology

Over the last 20 years, the idea of “designing biology” has gone from science fiction to just science, as the field of synthetic biology has exploded, with applications from therapeutics to manufacturing and more. In this episode from January 2019, one of the pioneers in the field, professor James J. Collins of MIT, joins a16z general partner on the Bio + Health fund, Vijay Pande, and editorial partner Hanne Winarsky, to discuss the origins of synthetic biology or "synbio", to what "engineering and designing" biology really looks like in action and the disciplinary differences between how biologists and engineers see the world.

6 Heinä 202236min

Mining the Data for Cobalt

Mining the Data for Cobalt

In this episode from July 2019, Kurt House, CEO and co-founder of Kobold Metals, John Thompson, professor of earth and geosciences at Cornell; and Connie Chan, a16z general partner for consumer, talk with editorial partner Hanne Winarsky about the way technology is transforming how we find cobalt, and the mining industry as a whole, as well as the science behind why cobalt is so critical for batteries, the data and knowledge behind mining today vs the past, and more.

29 Kesä 202233min

Applying AI in B2B

Applying AI in B2B

In this episode from October 2019, People.AI founder and CEO Oleg Rogynskyy and a16z partner Peter Lauten discuss with Das Rush about what the rise of AI in B2B means for enterprises, workers, and startups. They explain why AI provides a strong first mover advantage to enterprises that adopt it early; how it can automate lower level tasks, maximize our focus, and, ultimately, make our work more meaningful; and for startups, they provide a playbook for seizing the next AI opportunity.To learn more about the latest in AI, ML, data, and how enterprise are working with these technologies, go to future.com/data.

23 Kesä 202224min

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