Invisalign: Patents, Patients, and Profits - [Business Breakdowns, EP. 11]

Invisalign: Patents, Patients, and Profits - [Business Breakdowns, EP. 11]

Today, we will be breaking down Invisalign. Founded in 1997, Invisalign pioneered clear aligners as an alternative to metal braces. Today, Invisalign generates over $2bn of revenue and accounts for roughly 20% of the orthodontic market. To break down Invisalign, I am joined by Nick Greenfield, CEO of Candid. Nick co-founded Candid in 2017 as an e-commerce solution to teeth aligners. Candid now offers a broad range of clear aligners and teeth whitening solutions across retail, e-commerce, and the professional market. Nick's experience in the industry makes him an ideal person to explore Invisalign. We dive deep into the origin of the business, the unique relationship between Invisalign and orthodontists, the economics of orthodontics, and how Invisalign successfully used its patents to maintain its lead in the clear aligner industry. For the full show notes, transcript, and links to the best content to learn more, check out the episode page here. ----- Business Breakdowns is a property of Colossus, Inc. For more episodes of Business Breakdowns, visit joincolossus.com/episodes. Stay up to date on all our podcasts by signing up to Colossus Weekly, our quick dive every Sunday highlighting the top business and investing concepts from our podcasts and the best of what we read that week. Sign up here. Follow us on Twitter: @JoinColossus | @patrick_oshag | @jspujji | @zbfuss Show Notes [00:02:43] - [First question] - Overview of Align Technologies and their scale [00:03:31] - What Invisalign is and the problem it solves [00:04:43] - The footprint Invisalign has in the dental industry [00:08:40] - Defining orthodontics and the size of the market [00:09:49] - Why market penetration may double over the coming years [00:14:42] - What the market was missing in the 90s and allowed Invisalign to arise [00:16:20] - Unit economics across the value chain of orthodontics [00:19:40] - Economics of an entire practice built on Invisalign [00:20:34] - How they came to dominate and cement their market position [00:22:44] - Vertical integration and other ways held a majority in the clear liner space [00:25:02] - Branding, distribution and further means of competitive advantage [00:27:05] - Why not move further up the value chain and buy orthodontic businesses [00:28:40] - Invisalign’s P&L in gross margin and major item categories [00:31:49] - What share of chair means and why it’s important [00:32:56] - How many cases can currently be handled by clear alignment trays [00:34:52] - Orthodontists will remain employed once aligners achieve widespread adoption [00:37:16] - Driving factors for Invisalign doubling over the next five to ten years [00:39:03] - China’s push for training orthodontists and clear aligner adoption [00:39:50] - Other reasons Invalisgn may double their market cap over the coming years [00:40:26] - Competitors and disruptors that may hinder their growth [00:42:01] - Joy dichotomy between patients and businesses [00:43:40] - What happened in 2017, how it changed the marketplace, and the road ahead [00:45:08] - Market share and penetration in today’s landscape [00:46:23] - An analog that can be used to explain Invisalign writ large [00:47:31] - What could revert Invisalign’s growth and market share [00:50:22] - uLab and orthodontists making aligners themselves [00:51:53] - Other potential threats to Invisalign [00:53:26] - Patenting your IP and gaining an advantage in healthcare [00:55:28] - Lessons for builders and entrepreneurs from the Invisalign story [00:56:39] - Lessons for investors watching Invisalign’s growth over the years [00:58:07] - Where you can learn more; dentaltown Podcasts

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Toast: Sticky SaaS - [Business Breakdowns, EP.247]

Toast: Sticky SaaS - [Business Breakdowns, EP.247]

Today, we are breaking down Toast, a name we have covered before but are revisiting because the story has changed enough to be worth telling again. Most listeners will have tapped a Toast terminal wit...

29 Touko 49min

Auto1: EU-sed Car Marketplace - [Business Breakdowns, EP.246]

Auto1: EU-sed Car Marketplace - [Business Breakdowns, EP.246]

Today, we are breaking down Auto1, and this is an interesting episode because we are tackling a business that most US listeners will not be familiar with, even though it resembles names they already k...

15 Touko 1h 5min

Opendoor: Q1 2026 Earnings - [Business Breakdowns, EP.245]

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Today, we are breaking down Opendoor, and this is a unique episode. We recorded with Kaz Nejatian, the CEO of Opendoor, shortly after the company reported its first quarter 2026 earnings, and we cover...

8 Touko 25min

PriceSmart: Central America’s Costco - [Business Breakdowns, EP.244]

PriceSmart: Central America’s Costco - [Business Breakdowns, EP.244]

Today, we are breaking down PriceSmart, the membership warehouse club operating across Central America, the Caribbean, and South America. I came away from this episode with a new appreciation for how ...

1 Touko 56min

Altius Minerals: Royalty Check - [Business Breakdowns, EP.243]

Altius Minerals: Royalty Check - [Business Breakdowns, EP.243]

Today, we are breaking down Altius Minerals, a Canadian royalty company that stands apart from the precious metals and oil and gas names that usually define the category. 17 people in Newfoundland con...

24 Huhti 33min

Givaudan: The Magic Ingredients - [Business Breakdowns, EP.242]

Givaudan: The Magic Ingredients - [Business Breakdowns, EP.242]

Today, we are breaking down Givaudan, the Swiss fragrance and flavor giant hiding in plain sight. I came away from this episode with a new way of seeing the world around me. When you learn that a sing...

17 Huhti 41min

Apollo: Connoisseurs of Complexity - [Business Breakdowns, REPLAY]

Apollo: Connoisseurs of Complexity - [Business Breakdowns, REPLAY]

This episode was originally recorded in March 2025.  ​Today, we are breaking down the  global alternative asset manager, Apollo. I reflected on my personal experiences with Apollo for this episode, an...

20 Maalis 1h 14min

Cognex: Vision Quest - [Business Breakdowns, REPLAY]

Cognex: Vision Quest - [Business Breakdowns, REPLAY]

This conversation was originally released in February of 2025. We’re replaying this episode because Cognex sits right at the intersection of AI and robotics. As the market focuses more on physical AI ...

13 Maalis 44min

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