Permissive azotemia during AKI enables more rapid renal recovery and less renal fibrosis
ESICM Talk17 Touko 2023

Permissive azotemia during AKI enables more rapid renal recovery and less renal fibrosis

Preclinical models of acute kidney injury (AKI) consistently demonstrate that a uremic milieu enhances renal recovery and decreases kidney fibrosis.

Reduced renal clearance has the surprising and counterintuitive effect of being an effective treatment for AKI.

In this perspective, Dr Lakhmir S. Chawla suggests a hypothesis describing why the uremic milieu is kidney protective and proposes a clinical trial of ‘permissive azotemia’ to improve renal recovery and long-term renal outcomes in critically ill patients with severe AKI.

Hear more about the explanation of this hypothesis in the following podcast, organised by the ESICM AKI Section.

Speakers

Lakhmir S. CHAWLA. Chief Medical Officer, Silver Creek Pharmaceuticals. Recipient of the International Vicenza Award for Critical Care Nephrology.

Eric HOSTE. UZ Gent (BE). AKI Section Representative, ESICM Social Media & Digital Content Committee.

Marc ROMAIN. Hadassah Medical Center, Jerusalem (IL).

Jaksot(90)

Machine-learning-derived sepsis bundle of care

Machine-learning-derived sepsis bundle of care

The Surviving Sepsis Campaign (SSC) produces and regularly updates guidelines for managing patients with sepsis and septic shock. However, deviation from guidelines is frequently observed in the inten...

22 Maalis 202326min

How to use biomarkers of infection or sepsis at the bedside

How to use biomarkers of infection or sepsis at the bedside

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. In this context, biomarkers could be considered indicators of either infection or dysregulated host ...

15 Maalis 202324min

MIPD of beta-lactam antibiotics and ciprofloxacin in critically ill patients

MIPD of beta-lactam antibiotics and ciprofloxacin in critically ill patients

Individualising drug dosing using model-informed precision dosing (MIPD) of beta-lactam antibiotics and ciprofloxacin has been proposed as an alternative to standard dosing to optimise antibiotic effi...

25 Tammi 202317min

Management of severe bronchiolitis in infants <12 months old admitted to paediatric ICU

Management of severe bronchiolitis in infants <12 months old admitted to paediatric ICU

Bronchiolitis is a common lung infection in young children and infants. Approximately one-tenth of the affected children are admitted, and between 2 and 6% of them present a severe form and are referr...

18 Tammi 202313min

Clustering analysis of geriatric and acute characteristics in very old patients on ICU admission

Clustering analysis of geriatric and acute characteristics in very old patients on ICU admission

The outcome of very old patients admitted to the intensive care unit (ICU) is determined by both the severity of the acute condition and the age-related decline of resilience to stress. However, that ...

11 Tammi 202312min

My evidence-based nutrition protocol

My evidence-based nutrition protocol

Nutrition is an essential care we provide to critically ill patients aiming to avoid severe muscle wasting and weakness, which correlate with mortality and long-term burdens. Considering that the ICU ...

23 Marras 202222min

Management and outcomes of pregnant women with COVID-19

Management and outcomes of pregnant women with COVID-19

Pregnant women with COVID-19 are more likely to be admitted to the ICU and require invasive mechanical ventilation or venovenous extracorporeal membrane oxygenation (VV-ECMO). Nevertheless, only a few...

12 Loka 202212min

Evolution of sedation management in the ICU

Evolution of sedation management in the ICU

Intensive care unit (ICU) sedation practices have dramatically changed over the last 20 years. Nowadays, they include light levels of sedation, SAT, and the use of non-benzodiazepines. An overview of ...

14 Syys 202214min

Suosittua kategoriassa Liike-elämä ja talous

sijotuskasti
psykopodiaa-podcast
mimmit-sijoittaa
rss-rahapodi
rss-lahtijat
rss-draivi
oppimisen-psykologia
rss-porssipuhetta
rss-rahamania
rahapuhetta
taloudellinen-mielenrauha
rss-neuvottelija-sami-miettinen
rss-bisnesta-bebeja
rss-paatos-podcast-suomen-kovimmat-paatoksentekijat-2
rss-seuraava-potilas
rss-inderes
rss-40-ajatusta-aanesta
kasvun-kipuja
rss-h-asselmoilanen
rss-porssipodi