Results from the TAME trial
ESICM Talk27 Kesä 2023

Results from the TAME trial

International guidelines recommend targeting normocapnia in adults with coma resuscitated after out-of-hospital cardiac arrest. However, normocapnia may be insufficient to restore and maintain adequate cerebral perfusion. Conversely, mild hypercapnia increases cerebral blood flow and may improve neurologic outcomes.

Nevertheless, the most effective Paco2 target in adults with coma resuscitated after out-of-hospital cardiac arrest has not been well studied in randomized trials.

Therefore, the Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest (TAME) trial was conducted to test the hypothesis that targeted mild hypercapnia would improve neurologic outcomes at 6 months as compared with targeted normocapnia in adults with coma who had been resuscitated after out-of-hospital cardiac arrest.

Listen to the podcast for more insight into the hypothesis, methodology and findings from the TAME study.

Original paper: Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest

Speakers

Claudio SANDRONI. Policlinico Universitario Agostino Gemelli, Rome (IT).

Markus SKRIFVARS. University of Helsinki (FI). Chair, ESICM Trauma & Emergency Medicine (TEM) Section.

Chiara ROBBA. University of Genova (IT). ESICM Neuro-Intensive Care (NIC) Section.

Tämä jakso on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi jakso saattaa sisältää mainontaa.

Jaksot(101)

2025 ESICM guidelines on circulatory shock and haemodynamic monitoring

2025 ESICM guidelines on circulatory shock and haemodynamic monitoring

What has changed in the 2025 ESICM guidelines on circulatory shock and haemodynamic monitoring, and what does it mean for clinical practice?In this podcast, our guest, Dr Antonio Messina, Chair of the...

23 Syys 32min

Drug Clearance in RRT: What Are the Determinants?

Drug Clearance in RRT: What Are the Determinants?

How do you optimise drug dosing in a critically ill patient undergoing continuous renal replacement therapy (CRRT)? Drug dosing during CRRT can be challenging, with multiple factors influencing drug c...

14 Syys 54min

2026 World Sepsis Day: From Awareness to Action

2026 World Sepsis Day: From Awareness to Action

This year, ESICM is proud to mark World Sepsis Day with a special podcast, "From Awareness to Action," featuring ESICM President Jan De Waele in conversation with Krista Bracke, sepsis survivor and ad...

12 Syys 43min

Heatstroke

Heatstroke

Why should every ICU clinician be prepared to recognise heat stroke?In this podcast, we explore the importance of early recognition and treatment of heat stroke, from the emergency department to the I...

26 Elo 30min

Is the curtain falling on pre-hospital whole blood?

Is the curtain falling on pre-hospital whole blood?

Whole blood has made a remarkable comeback in trauma care—but is it here to stay? In this thought-provoking podcast, leading experts unpack the latest evidence comparing whole blood with component the...

6 Heinä 25min

Switching from controlled to assisted ventilation: evidence, risks, and opportunities in AHRF?

Switching from controlled to assisted ventilation: evidence, risks, and opportunities in AHRF?

What are the benefits of moving from controlled to assisted mechanical ventilation in patients with Acute Hypoxemic Respiratory Failure (AHRF)? In this podcast, experts discuss the physiological ratio...

8 Kesä 38min

Biomarkers in Severe Infections and Sepsis - Moving from Trials to the Bedside

Biomarkers in Severe Infections and Sepsis - Moving from Trials to the Bedside

Sepsis care is evolving fast. Are you keeping up? Don’t miss this podcast episode, where we explore the latest clinical trials reshaping antibiotic therapy for severe infections, from optimised treatm...

27 Touko 25min

Advanced Practice in Nursing and Allied Health Professionals

Advanced Practice in Nursing and Allied Health Professionals

What does advanced practice really look like in the ICU? In this podcast episode, we are joined by two advanced intensive care practitioners who share their roles, career journeys, and impact within t...

13 Touko 43min

Suosittua kategoriassa Liike-elämä ja talous

sijotuskasti
vallattomat
psykopodiaa-podcast
rss-rahapodi
mimmit-sijoittaa
rss-oivalluksia-rahasta-elamasta
ostan-asuntoja-podcast
rss-rahamania
rss-hereilla
oppimisen-psykologia
sijoituspodi
hyva-paha-johtaminen
rss-inderes
rss-paasipodi
rss-porssipuhetta
rss-karon-grilli
rss-kahavia-ja-markkinointia-podcast
pomojen-suusta
rss-alanvaihtajat
rss-10x-finland