Ep. 400 Intra-Arterial Approaches in Tumor Therapy: Overcoming the Blood-Brain Barrier with Dr. Piotr Walczak and Dr. Prakash Ambady

Ep. 400 Intra-Arterial Approaches in Tumor Therapy: Overcoming the Blood-Brain Barrier with Dr. Piotr Walczak and Dr. Prakash Ambady

In this episode of the Backtable Podcast, guest host Dr. Paul Bhogal, a consultant interventional neuroradiologist at Royal London Hospital in the UK, and guests Dr. Piotr Walczak and Dr. Prakash Ambady discuss the potential of intra-arterial treatments combined with blood brain barrier (BBB) manipulation in treating various neurological conditions and tumors. The trio of doctors discuss methods such as the use of hyperosmolar mannitol and focused ultrasound to breach the BBB and deliver drugs directly to the brain tissue. Dr. Walczak and Dr. Ambady also highlight their individual research areas, including therapies involving cell delivery and engineered cells. The conversation also covers potential risks and new perspectives in comparison to current techniques such as whole-brain radiation. --- CHECK OUT OUR SPONSOR RADPAD® Radiation Protection https://www.radpad.com/ --- SHOW NOTES 00:00 - Introduction 05:44 - Challenges of Treating Glioblastoma Multiforme 12:52 - Understanding the Blood Brain Barrier 18:30 - Strategies to Negate the Blood Brain Barrier 20:52 - Blood Brain Barrier Disruption Using Intra-Arterial Mannitol 26:35 - Infusion Rates and Magnetic Resonance Guidance 33:47 - Role of Radiolabel Studies in Drug Delivery 36:31 - Future of Therapeutic Agents Design 47:54 - Potential of Focused Ultrasound in Drug Delivery 56:10 - Exploring the Use of Cells in Drug Delivery 58:44 - Future of Intra-Arterial Interventions --- RESOURCES Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma: https://pubmed.ncbi.nlm.nih.gov/15758009/ Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomized phase III study: 5-year analysis of the EORTC-NCIC trial: https://pubmed.ncbi.nlm.nih.gov/19269895/ REMOVAL OF RIGHT CEREBRAL HEMISPHERE FOR CERTAIN TUMORS WITH HEMIPLEGIA - PRELIMINARY REPORT: https://jamanetwork.com/journals/jama/article-abstract/254927 Real-Time MRI Guidance for Reproducible Hyperosmolar Opening of the Blood-Brain Barrier in Mice: https://www.researchgate.net/publication/328537972_Real-Time_MRI_Guidance_for_Reproducible_Hyperosmolar_Opening_of_the_Blood-Brain_Barrier_in_Mice Dr. Piotr Walczak ResearchGate Profile: https://www.researchgate.net/profile/Piotr-Walczak-6 Dr. Prakash Ambday ResearchGate Profile: https://www.researchgate.net/profile/Prakash-Ambady Maculopathy Associated With Osmotic Blood- Brain Barrier Disruption and Chemotherapy in Patients With Primary CNS Lymphoma: https://pubmed.ncbi.nlm.nih.gov/32484895/ PET imaging of intra-arterial 89 Zr bevacizumab in mice with and without osmotic opening of the blood-brain barrier: distinct advantage of intra-arterial delivery: 10.2967/jnumed.118.218792 Safety of intra-arterial chemotherapy with or without osmotic blood–brain barrier disruption for the treatment of patients with brain tumors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307096/ Delivery of chemotherapeutics across the blood-brain barrier: challenges and advances: https://pubmed.ncbi.nlm.nih.gov/25307218/

Jaksot(619)

Ep. 19 Lymphatic Interventions with Dr. Chick and Dr. Srinivasa

Ep. 19 Lymphatic Interventions with Dr. Chick and Dr. Srinivasa

Our holiday episode featuring Dr. Jeffrey Chick and Dr. Ravi Srinivasa of University of Michigan. They sit fireside with our host J. Michael Barraza Jr. to discuss lymphatic interventions in IR.

27 Joulu 201748min

Ep. 18 Complex LE Venous Interventions with Dr. Jeffrey Chick and Dr. Ravi Srinivasa

Ep. 18 Complex LE Venous Interventions with Dr. Jeffrey Chick and Dr. Ravi Srinivasa

Dr. Jeffrey Chick and Dr. Ravi Srinivasa discussing complex lower extremity venous interventions at University of Michigan VIR.

18 Joulu 201756min

Ep. 17 Prostate Artery Embolization with Dr. Ari Isaacson and Dr. Sandeep Bagla

Ep. 17 Prostate Artery Embolization with Dr. Ari Isaacson and Dr. Sandeep Bagla

Special guests Dr. Ari Isaacson and Dr. Sandeep Bagla sharing their experiences with prostate artery embolization, including a candid discussion on practice building, equipment, and a brief intro on what to expect at the upcoming STREAM PAE course Jan 13 in Washington DC.

20 Marras 201747min

Ep. 16 Pressure-Directed Therapy in Y90 with Dr. Nutting and Dr. Parikh

Ep. 16 Pressure-Directed Therapy in Y90 with Dr. Nutting and Dr. Parikh

In our first podcast on pressure directed therapy, Dr. Charles Nutting and Dr. Nainesh Parikh discuss some of the first principles of Y90 radioembolization delivery, and the potential advantages of pressure directed devices over end-hole catheters in the treatment of HCC.

5 Marras 201731min

Ep. 15 Renal Ablation Therapies with Dr. Mike Devane and Dr. Ahmed Kamel

Ep. 15 Renal Ablation Therapies with Dr. Mike Devane and Dr. Ahmed Kamel

We discuss renal ablation therapies with Mike Devane MD and Ahmed Kamel MD, PhD, FSIR

1 Marras 201732min

Ep. 14 Novel Bariatric and Pain Therapies with Dr. David Prologo

Ep. 14 Novel Bariatric and Pain Therapies with Dr. David Prologo

Podcast episode 14 with J. David Prologo and J. Michael Barraza Jr. discussing Novel Bariatric and Pain Interventions.

20 Loka 201728min

Ep. 13 Neurovascular IR Part 2: Devices

Ep. 13 Neurovascular IR Part 2: Devices

Our docs discuss integrating neurovascular interventions (part 2) into your IR practice with Venu Vadlamudi and Sabeen Dhand.

2 Loka 201727min

Ep. 12 Neurovascular IR (Part 1) with Sabeen Dhand and Venu Vadlamudi

Ep. 12 Neurovascular IR (Part 1) with Sabeen Dhand and Venu Vadlamudi

Our docs discuss integrating neurovascular interventions (part 1) into your IR practice with Venu Vadlamudi and Sabeen Dhand.

2 Loka 201743min

Suosittua kategoriassa Koulutus

rss-murhan-anatomia
psykopodiaa-podcast
voi-hyvin-meditaatiot-2
rss-duodecim-lehti
aloita-meditaatio
jari-sarasvuo-podcast
rss-psykalab
psykologia
rss-vapaudu-voimaasi
adhd-podi
rss-narsisti
rss-niinku-asia-on
ihminen-tavattavissa-tommy-hellsten-instituutti
rss-liian-kuuma-peruna
aamukahvilla
kesken
rss-monarch-talk-with-alexandra-alexis
rss-koira-haudattuna
rss-anteeks-etukateen
tohtorin-vuoro