Spermidine – The Powerful AntiAging compound you’ve never heard of but is about to take the world by storm

Spermidine – The Powerful AntiAging compound you’ve never heard of but is about to take the world by storm

Primeadine
Spermidine – The Powerful AntiAging compound you’ve never heard of but that is about to take
the world by storm. In this episode I sit down with Leslie Kenny the CEO and Founder of
OxFord Healthspan – a company founded for the purpose of bringing powerful healthy/anti
aging compounds to market. Today we deep dive into their first entry which is rooted in
ancient knowledge and yet relatively new to the modern world. Consider that this compound
hits at least 5 of the 9 hallmarks of aging….even better, new research seems to point to its
ability to improve immune response in elderly adults by helping certain areas of the immune
system to reboot and rejuvenate!! Oxford Span is committed to making this
supplement available to as many people as possible – for the month of December you can
benefit from introductory pricing PLUS an additional 15% discount (BIONAT15 promo code). If
you are this after December 2020 the discount code will still work!!
Note that this supplement will produce most noticeable results in the 50+ crowd who are
already seeing a decline in endogenous spermidine production and is not appropriate for
people with celiac disease or severe wheat allergies – we talk about all this and more in the
episode….enjoy!!
6:08
Leslie’s story – from autoimmune disease & infertility to how she first came across spermidine
7:22
The link between ancient Japanese scrolls on longevity and sexual intimacy and spermidine
11:05
Compounds that target the 9 hallmarks of aging and the 5 specifically targeted by Spermidine
13:30
Dietary sources and the reason why supplement companies are having to extract spermidine
from wheat instead of Natto
15:30
Natto – possibly the best and most economical source of spermidine
17:33
Who should NOT use the current Spermidine supplements (including Primeadine) and why
18:02
Amount of gluten per serving vs a slice of
19:54
Why the 50+ crowd is likely to experience the best visible results from Primeadine
20:55

Endogenous and exogenous sources of spermidine
22:57
The physical signs that your spermidine production is declining
28:20
Short, medium and long term benefits
36:05
Maximum dose as determined by regulatory bodies
38:49
Getting back to the ancient Daoist Scrolls – the aging male’s advantage over women

45:29
Best time of day to take Primeadine
50:27
DO NOT mix with hot foods or beverages
52:25
Introductory pricing in place until December 31, 2020
15% discount code in place for December and the new year: BIONAT15
Website:
Primeadine.com or OxfordHealthSpan.com

Just a few of the growing list of studies assessing Spermidine’s possible benefits for human
and longevity
Studies/References
Effect on Hormones, Fertility in men and women
The regulatory effect of biogenic polyamines spermine and spermidine in men and women. Open
Journal of Endocrine and Metabolic Diseases, 9(03), 35
Spermidine Intake and Longevity in humans
Higher spermidine intake is linked to lower mortality: a prospective population-based study. The
American journal of clinical nutrition, 108(2), 371-380
The autophagy enhancer spermidine reverses arterial aging in aged mice. Mechanisms of ageing
and development, 134(7-8), 314-320.

Okamoto, A., Sugi, E., Koizumi, Y., Yanagida, F., & Udaka, S. (1997). Polyamine content of ordinary
foodstuffs and various fermented foods. Bioscience, biotechnology, and biochemistry, 61(9), 1582-
1584
Ramot, Y., Tiede, S., Bíró, T., Bakar, M. H. A., Sugawara, K., Philpott, M. P., ... & Paus, R. (2011).
Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell
functions. PLoS One, 6(7), e22564
Rinaldi, F., Marzani, B., Pinto, D., & Ramot, Y. (2017). A spermidine-based nutritional supplement
prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-
blind study. Dermatology Practical & Conceptual, 7(4), 17.
Schwarz, C., Horn, N., Benson, G., Calzado, I. W., Wurdack, K., Pechlaner, R., ... & Flöel, A. (2020).
Spermidine intake is associated with cortical thickness and hippocampal volume in older adults.
NeuroImage, 221, 117132
Dietary polyamine intake and colorectal cancer risk in postmenopausal women. The American
journal of clinical nutrition, 102(2), 411-419

And finally an article on new findings of the effects of Spermidine on immune function is elderly
humans:
https://www.longevity.technology/autophagy-in-t-cells-maintained-by-
spermidine/?utm_source=ZohoCampaigns

Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition before you make any changes.

Jaksot(365)

 #327: Testosterone for Women: Enhancing Strength, Libido, and Cognitive Function With Nat Niddam

#327: Testosterone for Women: Enhancing Strength, Libido, and Cognitive Function With Nat Niddam

Hey there, Longevity Podcast listeners! It's just me, Nathalie Niddam, in today's episode, diving into a subject that's often overlooked but super important—testosterone in women. Yes, you heard that right! While most people think of testosterone as a "male" hormone, it plays a crucial role in women's health, especially as we navigate through menopause.   What we discuss: Testosterone in Women ... 00:00:37 Muscle Challenges ... 00:02:10 Sexual Function ... 00:04:33 Energy Levels ... 00:05:14 Cognitive Function ... 00:05:56 Mood and Bone Health ... 00:05:56 Muscle and Cardiovascular Health ... 00:07:02 Somatic Symptoms ... 00:09:01 Sleep and Motivation ... 00:10:14 Cautions with Therapy ... 00:11:13 Administration Methods ... 00:14:38 Transdermal vs. Injectable ... 00:16:47   Our Amazing Sponsor: BiOptimizers - MassZymes is the most complete, most potent digestive enzyme with over 102% MORE PROTEASE than the nearest competitor. That’s crucial because protein is the most complex macronutrient to break down. Try MassZymes at bioptimizers.com/bionat and enter the coupon code BIONAT to get 10% off your order.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

18 Huhti 26min

#326: From Brain Fog to Focus: Techniques and Supplements to Enhance Cognitive Function With Kyal Van Der Leest

#326: From Brain Fog to Focus: Techniques and Supplements to Enhance Cognitive Function With Kyal Van Der Leest

In this episode of the Longevity Podcast, I sit down with my good friend and brilliant supplement formulator, Kyal Van Der Leest, who's known for his innovative work in the peptide space. Together, Kyal and I explore the fascinating world of brain health and uncover powerful strategies to boost cognitive function.    What we discuss: Mold toxicity and health effects ... 00:03:49 Kyal's journey and Level Up Health ... 00:04:26 Lifestyle factors in brain health ... 00:19:19 Role of BDNF in neuroplasticity ... 00:24:44 Overview of neurotransmitters ... 00:30:12 Tessa Fensin and market withdrawal ... 00:39:01 Peptides for brain health ... 00:46:18 Blood flow and botanicals ... 00:53:06 Liposomal delivery benefits ... 01:06:22 Creatine for brain health ... 01:13:02 Kyal's supplement quality commitment ... 01:19:04 Conclusion and product info ... 01:26:00   Our Amazing Sponsors: Timeline: Mitopure is a breakthrough supplement that promotes cellular renewal. It contains Urolithin A, which helps your body clear out damaged mitochondria and create new, efficient ones—giving you more sustainable energy. Timeline is offering 10% off your order of Mitopure now. Go to timeline.com/NAT10.   Wizard Sciences (Neural Rx) - isn’t just about a quick boost. It’s designed to protect your brain long-term. With C60 (an antioxidant) and anti-inflammatory benefits, it combats oxidative stress and helps keep those brain cells healthy and happy. It supports mitochondrial efficiency, for more energy and focus for the long haul. Use code NAT15 at checkout to get 15% off your purchase. Visit wizardsciences.com.   Young Goose L.A.D.R. Serum -  Powered by light-activated DNA repair enzymes, NAD+, and collagen peptides, it reverses damage. Sunlight? Red light therapy? It all helps this serum work smarter, not harder. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you’re an existing customer. Future-proof your face.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

15 Huhti 1h 27min

#325: No More 3PM Burnout: How to Have A Successful Workday AND Energy Left for What Matters Most At The End Of The Day with Greg Kelly

#325: No More 3PM Burnout: How to Have A Successful Workday AND Energy Left for What Matters Most At The End Of The Day with Greg Kelly

Today’s guest, Dr. Gregory Kelly, creator of Qualia Mind, has spent years studying how to help people think faster, age better, and avoid that 3 p.m. crash that turns you into a zombie.  If you’ve ever wished for an extra gear in your mental engine, this is the episode for you! And if you are interested in giving it a try, visit qualialife.com/nathalie and use promo code NATHALIE to save 15% on your order.    What we discuss: Difference Between Brain and Mind ... 00:07:03 Mental Energy and Brain Function ... 00:09:49 Glucose and Ketones as Brain Fuel ... 00:17:45 Nootropic Supplements and Their Impact ... 00:24:53 Stacking Compounds for Cognitive Performance ... 00:34:07 Short-term and Long-term Benefits of Ingredients ... 00:43:18 Using Nootropics Like Qualia Mind for Performance ... 00:52:28 Safety and Effectiveness of Ingredient Stacking ... 01:16:40 Five Tips for Maintaining Cognitive Energy ... 01:19:15 Conclusion and Final Thoughts ... 01:26:28   Our Amazing Sponsors: STEMREGEN - Triggers the release of 10 million of your own stem cells, supporting tissue repair, recovery, and overall longevity. Visit stemregen.co/NAT15 and use code: NAT15 for 15% off your order.   BEAM - These minerals come from humate, a natural substance formed over millions of years as freshwater plants broke down and deposited their nutrients into the soil. Over time, those minerals concentrated into this black, crystalline material that’s now one of the most mineral-dense substances on earth. Visit https://www.beamminerals.com/NAT20 and use code NAT20 for 20% off.   Profound Health - Nature’s Marvels have been making bioregulators for over a decade, working directly with Prof. Khavinson, the pioneer of Bioregulator science! They’re manufactured in the UK. They’re GMP and HACCP certified and FDA-compliant. Head to profound-health.com and use code NAT15 for 15% off your first order.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

11 Huhti 1h 28min

#324: Master Your Nervous System: Overcoming Toxic Loads & Trauma for Better Health with Dr Jess Peatross

#324: Master Your Nervous System: Overcoming Toxic Loads & Trauma for Better Health with Dr Jess Peatross

In this episode of the Longevity Podcast, host Nathalie Niddam welcomes Dr. Jess Peatross, a former hospitalist turned functional medicine expert, to delve into the intricacies of nervous system regulation and terrain theory.   What we discuss: Themes of Terrain Theory and Germ Theory ... 00:07 Impact of Trauma on Health ... 00:10 Dr. Jess's Personal Health Journey ... 00:14 Meditation and Mindset Practices ... 00:22 Explanation of MCV and Its Importance ... 00:26 The Role of the Heart Center ... 00:31 Nervous System Regulation Tools ... 00:50 Mind and Body Coherence ... 00:54 Conclusion and Positive Message ... 01:00 Where to Find Dr. Jessica Petros ... 01:01   Our Amazing Sponsors: Young Goose L.A.D.R. Serum -  Powered by light-activated DNA repair enzymes, NAD+, and collagen peptides, it reverses damage while you go about your life. Sunlight? Red light therapy? It all helps this serum work smarter, not harder. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you’re an existing customer.   Qualia - NAD+ This vital molecule powers cellular energy, supports DNA health, aids detox, and helps keep your body remain youthful. Visit qualialife.com/nathalie to try Qualia NAD+, backed by a 100-day money-back guarantee, and use promo code NATHALIE for 15% off! Quantum Upgrade Imagine plugging yourself into a limitless power source. It’s been rigorously tested and shown to improve blood flow, reduce stress, and even boost cellular energy by up to 29%. Go to quantumupgrade.io/NAT and start running life, instead of life running you. Use code NAT10 to get a 15-day free trial on the All-in-One Frequency Bundle. Good through June 1st, 2025.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

8 Huhti 1h 2min

#323: Understanding Sugar Alternatives | Which Ones Are Better For You with Nathalie Niddam

#323: Understanding Sugar Alternatives | Which Ones Are Better For You with Nathalie Niddam

In this episode, Nathalie explores the captivating world of sweeteners, from the natural delights of honey and maple syrup to modern alternatives like stevia, monk fruit, and artificial sweeteners.    Resources from the episode: What Are the Dangers of Erythritol? Aspartame Side Effects: Recent Research Confirms Reasons for Concern Trehalose: Benefits, Uses, Food Sources & Dangers Is Allulose a Healthy Sweetener?   What I discuss: Anthropological Perspective on Sweetness ... 00:01:37 Brains Glucose Utilization and Sugar Relationship ... 00:02:03 Sugar Addiction and Sweet Cravings ... 00:03:00 Exploration of Food-Based Sweeteners ... 00:04:17 Detailed View on Honey ... 00:05:27 Maple Syrup Overview ... 00:07:14 Stevia - Pros and Cons ... 00:08:02 Monk Fruits Benefits ... 00:10:59 Coconut Sugar Insights ... 00:12:04 Artificial Sweeteners Discussion ... 00:13:06 Sucralose Controversy ... 00:13:37 Saccharin and Historical Concerns ... 00:14:08 Aspartame Risks ... 00:15:13 Sugar Alcohols - Xylitol ... 00:16:50 Erythritol Concerns ... 00:19:56 Potential of Allulose ... 00:21:14 Trehalose Properties ... 00:23:24 Final Thoughts on Sweeteners and Detox ... 00:25:57   Our Amazing Sponsor: LVLUP - Neuro Re-Generate: the world's first liposomal triple peptide formula, designed to support mental clarity, focus, and overall brain health. Visit www.lvluphealth.com and use code NAT for 20% off your order.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

4 Huhti 34min

#322: Vitamin C: Your Secret Weapon Against Disease and Aging with Dr. Tom Levy

#322: Vitamin C: Your Secret Weapon Against Disease and Aging with Dr. Tom Levy

What if I told you that one of the biggest secrets to staying young, fighting disease, and even keeping your heart and arteries in top shape isn’t just about hitting the gym or eating clean?   Products mentioned in this episode: Lypo-Spheric® Vitamin C Sodium Ascorbate Powder   What we discuss: The Role of Oxidative Stress and Vitamin C ... 00:03 Introduction of Dr. Thomas Levy and His Journey ... 00:07 Oxidative Stress and Its Impact on Health ... 00:08 Exercise, Hormones, and Antioxidants ... 00:19 Critical Importance of Oral Health ... 00:30 Heavy Metals and Heart Health ... 00:45 Chelation and Detoxification Methods ... 00:47 Long COVID, Spike Protein, and Vitamin C Protocol ... 00:52 Discussion on Vitamin C Sources and Supplementation ... 01:00 Conclusion and Contact Information for Dr. Levy ... 01:06   Our Amazing Sponsors: Mitolux - Most therapy lamps just blast bright light at you, but Mitolux actually mimics real sunlight and includes red light therapy for extra wellness perks. Get a Mitolux Sunlamp for 10% off at https://mitolux.com/NAT10, NAT10 will be automatically applied at checkout.   Profound Health - Nature’s Marvels have been making bioregulators for over a decade, working directly with Prof. Khavinson, the pioneer of Bioregulator science! They’re GMP and HACCP certified and FDA-compliant. Visit profound-health.com and use code NAT15 for 15% off your first order. Timeline: Mitopure is a breakthrough supplement that promotes cellular renewal. It contains Urolithin A, which helps your body clear out damaged mitochondria and create new, efficient ones—giving you more sustainable energy. Timeline is offering 10% off your order of Mitopure now. Go to timeline.com/NAT10.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

1 Huhti 1h 7min

#321: Stronger, Faster, Pain-Free? The Surprising Benefits of Whole Body Vibration with Dr. Jason Conviser

#321: Stronger, Faster, Pain-Free? The Surprising Benefits of Whole Body Vibration with Dr. Jason Conviser

Today, we’re shaking things up—literally. My guest, Dr. Jason Conviser, is an exercise physiologist who specializes in helping people move better, whether they’re elite athletes or 90-year-olds who just want to pick up their grandkids. And he’s here to share the magnificent benefits of Power Plate. If you are already curious to learn more you can head to PowerPlate.com/nat to explore the benefits of Whole Body Vibration Therapy, and enjoy a special offer from Power Plate They’re giving you 20% OFF and access to exclusive resources.   What We discuss: Whole body vibration overview and personal introduction by Dr. Jason Conviser ... 00:06:29 Dr. Conviser's background and focus on medical fitness ... 00:07:25 Whole body vibration explained ... 00:12:09 Benefits of vibration for muscles and tendons ... 00:13:53 Warm-up efficiency and muscle performance ... 00:14:39 Recovery benefits of whole body vibration ... 00:15:21 Applications of whole body vibration across different fields ... 00:17:22 Insights on bone health and whole body vibration ... 00:23:17 Cortisol reduction benefits ... 00:23:51 Whole body vibration's role in achieving bone strength ... 00:24:21 Qualitative benefits of vibration in various populations ... 00:30:48 Case studies: Parkinson's and other conditions ... 00:32:33 Parkinson's and vibration therapy's impact ... 00:35:34 Frequency of use and practical applications ... 00:41:47 Power Plate's offerings and benefits of tools ... 01:02:09 Recommendations for young to middle-aged users ... 01:02:09 Complementary exercises with vibration and other tools ... 01:02:11 Vibration integration in cycling with Power Plate bike ... 01:02:11 Our Amazing Sponsors: LVLUP - Neuro Re-Generate is the world's first liposomal triple peptide formula, designed to support mental clarity, focus, and overall brain health. Visit www.lvluphealth.com and use code NAT for 15% off your order.   Qualia Senolytic is a clinically tested formula with 9 plant-based, vegan ingredients designed to help your body clear out zombie cells—so you can feel younger, faster. Visit qualialife.com/nathalie and use promo code NATHALIE to save 15%!   BiOptimizers - Magnesium Breakthrough -  The only full-spectrum magnesium supplement with 7 unique forms of magnesium that your body can actually use and absorb. Visit bioptimizers.com/bionat and use code BIONAT for 10% off your order.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Grou

28 Maalis 1h 11min

#320: Master Muscle Mass At Any Age: How Bioavailable Peptides Are Revolutionizing Muscle Repair, Improving Gut Health, & Supporting Immune Function With Michael Antonelli

#320: Master Muscle Mass At Any Age: How Bioavailable Peptides Are Revolutionizing Muscle Repair, Improving Gut Health, & Supporting Immune Function With Michael Antonelli

In this episode of the Longevity Podcast, I'm thrilled to be joined by industry innovator Michael Antonelli, Founder & CEO of Healthgevity. Together, we dive deep into cutting-edge strategies for optimizing metabolism, muscle health, and immunity.  Try Healthgevity and use promo code: NAT10.   What We discuss: Michael Antonelli's background and journey ... 00:07:41 The inspiration behind Healthgevity ... 00:10:24 Introduction to metabolic health ... 00:19:16 Discussion on Ignite 2.0 formulation ... 00:20:16 Dosing flexibility of Ignite 2.0 ... 00:23:48 DNF10 and its role in Ignite 2.0 ... 00:30:10 Building muscle with longevity supplements ... 00:31:09 Introduction to PeptiStrong and its benefits ... 00:32:33 The importance of gut health and immunity ... 00:41:43 Prime Gut Health formula details ... 00:42:15 Discussion on Biorepair ... 00:55:56 Introduction to Immuno Reboot ... 01:00:37 Importance of sleep and Serenity product ... 01:02:26 Details on Serenity formulation ... 01:05:00 Conclusion and where to find Healthgevity products ... 01:11:37   Our Amazing Sponsors: Young Goose L.A.D.R. Serum -  Powered by light-activated DNA repair enzymes, NAD+, and collagen peptides, it reverses damage while you go about your life. Sunlight? Red light therapy? It all helps this serum work smarter, not harder. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you’re an existing customer. Future-proof your face.   Quantum Upgrade - Imagine plugging yourself into a limitless power source. It’s been rigorously tested and shown to improve blood flow, reduce stress, and boost cellular energy by up to 29%. Try it today at quantumupgrade.io/NAT and start running life, instead of life running you. Use code NAT10 to get a 15-day free trial on the All-in-One Frequency Bundle. Good through June 1st, 2025.   Wizard Sciences (Neural Rx) - Neural Rx isn’t just about a quick boost. It’s designed to protect your brain long-term. With C60 (an antioxidant) and anti-inflammatory benefits, it combats oxidative stress and helps keep those brain cells healthy and happy. Plus, it supports mitochondrial efficiency, meaning more energy and focus for the long haul. Use code NAT15 at checkout to get 15% off your purchase. Visit wizardsciences.com.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

25 Maalis 1h 14min

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