SEQUOIA trial: Zanubrutinib + venetoclax in treatment-naïve patients with CLL/SLL
Lymphoma Hub12 Elo 2024

SEQUOIA trial: Zanubrutinib + venetoclax in treatment-naïve patients with CLL/SLL

During the European Hematology Association (EHA) 2024 Hybrid Congress, the Lymphoma Hub was pleased to speak to Paolo Ghia, Vita-Salute San Raffaele, Milan, IT. We asked about the latest updates from the SEQUOIA trial of zanubrutinib + venetoclax in treatment-naïve patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).


In this interview, Paolo Ghia shares data from Arm D of the phase III SEQUOIA (NCT03336333) study of patients with del(17p) and/or pathogenic TP53 mutation treated with zanubrutinib in combination with venetoclax. Ghia covers key preliminary outcomes, highlighting promising remission data and an increased depth of response measured over time. This interview concludes with a look at the future implications of these data, particularly on measurable residual disease-guided treatment cessation.


This educational resource is independently supported by BeiGene. All content is developed by SES in collaboration with an expert steering committee; funders are allowed no influence on the content of this resource.

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