112 | Fyodor Urnov on Gene Editing, CRISPR, and Human Engineering

112 | Fyodor Urnov on Gene Editing, CRISPR, and Human Engineering

Not too long ago nobody carried a mobile phone; now almost everybody does. That's the kind of rate of rapid progress we're seeing with our ability to directly edit genomes. With the use of CRISPR-Cas9 and other techniques, gene editing is becoming commonplace. How does that work — and perhaps more importantly, how are we going to put it to use? Fyodor Urnov has worked in this area from its beginning, having coined the term "gene editing." We talk about how this new technology can be used to cure or prevent disease, as well as the pros and cons of designer babies.

Support Mindscape on Patreon.

Fyodor Urnov received his Ph.D. in Biology from Brown University. He is currently professor of Genetic, Genomics, and Development in the Department of Molecular and Cell Biology at UC Berkeley, as well as Director for Technology and Translation at the Innovative Genomics Institute. His research focuses on using CRISPR gene-editing techniques to develop treatments for sickle cell disease, radiation injury, and other conditions, as well as guiding IGI researchers as they bring these therapies from the lab to the clinic.

Todays episode is sponsored by The Great Courses Plus. Mindscape listeners get a free trial if they sign up at http://thegreatcoursesplus.com/mindscape.

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Mindscape Ask Me Anything, Sean Carroll | August 2026

Mindscape Ask Me Anything, Sean Carroll | August 2026

Welcome to the August 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patr...

3 Elo 3h 57min

362 | Luis Bettencourt on the Universal Properties of Self-Organizing Cities

362 | Luis Bettencourt on the Universal Properties of Self-Organizing Cities

People who live in large cities produce more patents per person than those who live in small towns. They also walk faster down the street, and use less infrastructure per person. Indeed, the relations...

27 Heinä 1h 20min

361 | Bonnie Bassler on How Bacteria Talk and Work Together

361 | Bonnie Bassler on How Bacteria Talk and Work Together

One of the characteristics of life is that living organisms gather information and put it to use. Even one of the simplest lifeforms, bacteria, are able to sense features of their surroundings and alt...

20 Heinä 1h 15min

Mindscape Ask Me Anything, Sean Carroll | July 2026

Mindscape Ask Me Anything, Sean Carroll | July 2026

Welcome to the July 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreo...

13 Heinä 4h 3min

360 | Marc Berman on the Science of Touching Grass

360 | Marc Berman on the Science of Touching Grass

Modern life has, in many ways, removed us from the environments in which our ancestors lived and adapted. Not only do we spend time looking at screens, but we spend time indoors, or outdoors but in ur...

6 Heinä 1h 29min

359 | Solo: Theories of Dark Energy

359 | Solo: Theories of Dark Energy

The cosmological constant, as discussed last episode, provides a perfectly good (thus far) explanation for why we observe the universe to be accelerating. But it might not be the right explanation, an...

29 Kesä 1h 56min

358 | Solo: Vacuum Energy and the Cosmological Constant

358 | Solo: Vacuum Energy and the Cosmological Constant

The most surprising discovery in fundamental physics during my career as a scientist was undoubtedly the acceleration of the universe, announced in 1998. The most straightforward explanation for these...

22 Kesä 1h 59min

357 | Jeff Coller on mRNA, Vaccines, and Bespoke Therapeutics

357 | Jeff Coller on mRNA, Vaccines, and Bespoke Therapeutics

Messenger RNA (mRNA) plays a literally central role in the functioning of life as we know it, shuttling information back and forth between the DNA where it is stored to the ribosome where it is used t...

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