Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas3 Helmi 2020

82 | Robin Carhart-Harris on Psychedelics and the Brain

The Convention on Psychotropic Substances was a 1971 United Nations treaty that placed strong restrictions on the use of psychedelic drugs — not only on personal use, but medical and scientific research as well. Along with restrictions placed by individual nations, it has been very difficult for scientists to study the effects of psychedelics on the brain, despite indications that they might have significant therapeutic potential. But this has gradually been changing, and researchers like Robin Carhart-Harris have begun to perform controlled experiments to see how psychedelics affect the brain, and what positive uses they might have. Robin and I talk about how psychedelics work, how they can help with conditions from addiction to depression, and how they can help people discover things about themselves.

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Robin Carhart-Harris received his Ph.D. in psychopharmacology from the University of Bristol. He is currently the Director of the Centre for Psychedelic Research in the Department of Brain Sciences at Imperial College London, and holds an honorary position at the University of Oxford. His research involves functional brain imaging studies with psilocybin (magic mushrooms), LSD, MDMA (ecstasy) and DMT (ayahuasca), plus a clinical trial of psilocybin for treatment-resistant depression.

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336 | Anil Ananthaswamy on the Mathematics of Neural Nets and AI

Machine learning using neural networks has led to a remarkable leap forward in artificial intelligence, and the technological and social ramifications have been discussed at great length. To understan...

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AMA | November 2025

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335 | Andrew Jaffe on Models, Probability, and the Universe

Science has an incredibly impressive track record of uncovering nonintuitive ideas about the universe that turn out to be surprisingly accurate. It can be tempting to think of scientific discoveries a...

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334 | Daniel Whiteson on the Physics of and by Aliens

The universe as revealed by physics is objective: it's out there, existing and behaving in ways that are completely independent of human thought. But the process by which we learn about the universe, ...

3 Marras 20251h 14min

333 | Gordon Pennycook on Unthinkingness, Conspiracies, and What to Do About Them

Why are people wrong all the time, anyway? Is it because we human beings are too good at being irrational, using our biases and motivated reasoning to convince ourselves of something that isn't quite ...

27 Loka 20251h 10min

332 | Dmitri Tymoczko on the Mathematics Behind Music

Music is math that you can dance to. The fact that certain notes sound good when played together, or in succession, is related to the mathematical properties of the frequencies to which they correspon...

20 Loka 20251h 21min

AMA | October 2025

Welcome to the October 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Pat...

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331 | Solo: Fine-Tuning, God, and the Multiverse

Certain features of our universe seem unnatural to us. These include "constants of nature" such as the cosmological constant and the mass of the Higgs boson, as well as features of the initial conditi...

6 Loka 20251h 54min