Is Red Meat the Fountain of Youth? Paul Saladino : 1229

Is Red Meat the Fountain of Youth? Paul Saladino : 1229

Does Calorie Restriction Even Work? What About the Carnivore Diet AND Fruit?

Today we are excited to have Paul Saladino join us for a masterclass on food and diets. Dr. Saladino dives into the evolution of keto and carnivore diets, cutting through trends to focus on lasting health impacts. Dr. Saladino, widely recognized as CarnivoreMD, shares how his own diet shifted to include fruit and honey alongside animal-based nutrition, and why metabolic flexibility—not rigid rules—leads to better outcomes. Together, he and Dave challenge assumptions about long-term ketosis, examine its potential downsides, and explore how to optimize diets for energy, gut health, and longevity.

They also tackle controversial topics like the risks of seed oils, the overhyped reputation of “health foods” like quinoa, and the critical roles insulin and nutrient density play in overall wellness. With insights on balancing mTOR, managing omega fats, and incorporating organ meats, this episode offers a nuanced perspective for anyone interested in biohacking, nutrition science, or simply eating smarter.

What you’ll learn:

• Why metabolic flexibility matters more than strict diet rules

• The science behind long-term ketosis and insulin’s broader role in health

• How common “health foods” could be doing more harm than good

• The importance of nutrient-dense animal-based foods for gut and immune health

• How to achieve optimal balance between fat types, mTOR, and longevity markers

Resources:

2025 Biohacking Conferencehttps://biohackingconference.com/2025

Shop Paul Saladino’s Productshttps://heartandsoil.co

Follow Paul Saladino on Instagramhttps://www.instagram.com/paulsaladinomd/

Paul Saladino’s Book: The Carnivore Codehttps://www.amazon.com/Carnivore-Code-Unlocking-Returning-Ancestral/dp/035846997X

Lineage Provisions – 100% Grass-Fed Beef Tallowhttps://lineageprovisions.com/products/100-grass-fed-beef-tallow

Danger Coffeehttps://dangercoffee.com

Danger Coffee Instagramhttps://www.instagram.com/dangercoffeeofficial/

Dave Asprey’s Websitehttps://daveasprey.com

Dave Asprey’s Book: Smarter Not Harderhttps://daveasprey.com/books

Dave Asprey’s Linktreehttps://linktr.ee/daveasprey

Upgrade Collective: Join The Human Upgrade Podcast Livehttps://www.ourupgradecollective.com

Own an Upgrade Labshttps://ownanupgradelabs.com

Upgrade Labshttps://upgradelabs.com

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancementhttps://40yearsofzen.com


Sponsors:

- Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.

- LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/dave.


Timestamps:

00:00 Intro

00:40 Paul Saladino’s Evolution in Diet

01:21 Challenges of a Strict Carnivore Diet

03:36 Reintroducing Carbohydrates

05:32 Debunking Common Diet Myths

13:49 The Problem with Calorie Restriction

18:30 The Importance of Food Quality

24:08 The Veganism Debate

34:15 The Benefits of Organ Meats

37:27 Foot Surgery and Bone Density

39:23 Mineral Deficiency and Plant-Based Diets

40:00 The Truth About Seed Oils

41:10 Historical Studies on Seed Oils

47:26 Mechanisms and Effects of Seed Oils

52:33 Nicotine and Neuroprotection

54:12 Oleic Acid and Longevity

01:01:44 The Benefits of Animal Fats

01:02:32 Odd Chain Fatty Acids and Health

01:11:07 Cheese and Dairy Considerations

01:13:11 The Impact of Cheese on Health

01:14:03 Protein Intake and Longevity

01:14:54 Understanding mTOR and Its Effects

01:17:35 Ideal Body Fat and Metabolic Health

01:24:38 The Role of Omega Fatty Acids

01:32:46 ApoB, Insulin Sensitivity, and Longevity

01:43:09 Final Thoughts and Product Recommendations


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Jaksot(1387)

The Superfoods That Are Killing You – Teri Cochrane : 1128

The Superfoods That Are Killing You – Teri Cochrane : 1128

Today, we’re digging into specifics about food that you haven’t heard on the show before. This one may very well influence you to rethink your “healthy” diet and change how you feel about food completely. To get there, I’m excited to welcome back Teri Cochrane, an integrative practitioner and pioneer in personalized healthcare. Teri is the founder of the Global Sustainable Health Institute® and developer of The Cochrane Method®, a future-facing algorithm for decoding the human body. Teri is also one of the world’s leading experts on dietary amyloids, which is a topic I love talking about.In today’s episode, we get into what amyloids are and how they turn on viruses, cause cancer, and shorten our lives. We also explore the dangers of oxalates and histamines, plus hacks to reduce and release them. Teri and I both have our own recipes for releasing oxalates that you can try at home (they’re surprisingly simple). We talk about how dirty poultry is killing us—and how superfoods like kale and almonds aren’t any better. We break down the benefits of regenerative farming, and share ways to make your dollar stretch if you can’t afford grass-fed meat. Plus, Teri tells us what she personally eats. (00:02:01) The Big 4 Metabolic Impairments(00:08:21) The Dangers of Oxalates(00:12:02) The Fifth Disruptor: Histamine(00:16:22) Becoming Your Own Body Interpreter(00:28:41) How Do We Get Off Oxalates?(00:35:41) Dave’s Recipe for Releasing Oxalates(00:44:40) Hacks for Histamines(00:50:32) Amyloid 101: What You Should Know(00:56:56) Should You Beware of B6?(00:59:54) What’s the Best Kind of Protein?SponsorsCalroy Arterosil & Vascanox Bundle | Head over to calroy.com/dave for an exclusive discount.ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: tericochrane.comInstagram: @tericochranebeyondnutritionYouTube: @TeriCochraneThe Global Sustainable Health Institute: globalsustainablehealthinstitute.comRead: The Wildatarian Diet by Teri Cochrane What You Eat is Turning Your Genes On and Off – Teri Cochrane – #646The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Tammi 20241h 15min

Knees Over Toes: Fix Knees, Calves, Shins & Shoulders – Ben Patrick : 1127

Knees Over Toes: Fix Knees, Calves, Shins & Shoulders – Ben Patrick : 1127

Meet the man who’s making leaps forward in functional movement training. Ben Patrick (aka the Knees Over Toes Guy) went from chronic knee issues to becoming a dunking sensation with his remarkable 42-inch vertical leap. His journey led him to discover the unconventional “knees over toes” method. He now trains to reverse joint pain and defy aging.In this episode, Ben shares his three game-changing foundations of exercise. We look back at the history of backward walking, and talk about its benefits today. Ben gives us his best tips for strengthening and healing knees, calves, shins, hip flexors, and shoulders. We start from the ground up with fixes for feet and toes. Plus, we talk about the problem with most shoes.Today’s biggest takeaway is recognizing the connection between functional movement and longevity. Functional training is key to how long you live and how well you live. Whether you’re 18 and want to do parkour or you’re 80 and want to get up off the floor—or still do parkour—you’ll want to hear this one. (00:04:45) What’s Up With Knees Over Toes?(00:13:58) Strengthening Joints, Not Just Muscles(00:19:54) Starting Off on the Right Foot(00:28:21) Taking It Back to Basics(00:38:30) Will These Workouts Help or Hurt Your Joints?(00:45:09) Fixes From the Toes Up(00:53:48) How To Have Healthy Hip Flexors(01:00:33) Healthy Movement Patterns for Life(01:03:03:) Secrets To Shoulder Healing(01:05:50) Marketing That Actually Helps PeopleSponsorsQuantum Upgrade | Go to QuantumUpgrade.io/Dave for a 7-day free trialResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: atgonlinecoaching.comATG Equipment: atgequipment.comInstagram: @kneesovertoesguyYouTube: @TheKneesovertoesguy TikTok: @kneesovertoesguyBiohacking Conference: biohackingconference.comThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Tammi 20241h 12min

Biohack Like a Woman – Aggie Lal : 1126

Biohack Like a Woman – Aggie Lal : 1126

Today, we're learning how to Biohack like a Woman. And trust me, it's not about counting calories or giving up your favorite foods; it's a whole new paradigm. I'm thrilled to introduce you to our incredible guest today, someone I've had the privilege of working with for several years—Aggie Lal aka Biohacking Bestie. Aggie is not your average biohacker; she's a public figure, bestselling author, health coach and a TEDx Speaker. She's been featured on TV and started the renowned Travel her Shoes blog over a decade ago, eventually leading her down the path of biohacking after realizing the toll constant travel can take on your health.Aggie's journey has led her to establish the Higher Self Academy, where she offers courses to help individuals, especially women, personalize their biohacking journeys. She's also the host of the Biohacking Bestie podcast—make sure to check out our recent conversation on her show. I love the work Aggie’s doing so much, that I even wrote the foreword for her groundbreaking new book, Biohack Like a Woman, which is all about revolutionizing weight loss and biohacking specifically tailored for women.In today's episode, we delve into topics like fertility, understanding perimenopause, and exploring distinct biohacking recommendations for men and women. Aggie and I discuss why women must honor their cycle when trying new practices and the common challenges women face when under-eating calories and exercising. Plus, Aggie shares her valuable nutritional advice for women, including protein intake per meal. (00:02:01) Aggie’s Mission To Empower Women Through Biohacking(00:10:46) Addressing Stress Response Capacity & The Importance of Rest & Recovery(00:21:12) Biohacking Your Cycle, Fertility & Birth Control(00:34:55) Nourishing Women: Understanding the Impact of Caloric Deficiency & Exercise(00:44:53) Embracing New Relationship Dynamics & Women’s Innate Power(00:54:24) How Biohacking Is Disrupting Mainstream Medicine(00:59:21) Nutritional Recommendations for WomenSponsorsBiOptimizers Magnesium Breakthrough | Go to bioptimizers.com/dave for 10% off your order.ARMRA | Try it out for yourself at tryarmra.com. Use code DAVE to get 15% off your first order.ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Read: Biohack Like a Woman Biohacking Bestie: biohackingbestie.comHigher Self Academy: higherselfacademy.coInstagram: @aggieInstagram: @biohackingbestieYouTube: @biohackingbestieTikTok: @biohackingbestieBiohacking Bestie Podcast: biohackingbestie.com/pages/biohacking-bestie-podcastThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Tammi 20241h 15min

From Tech to Table: Kimbal Musk's Culinary Revolution : 1125

From Tech to Table: Kimbal Musk's Culinary Revolution : 1125

Today’s very special episode comes from inside Kimbal Musk’s kitchen, where I get a hands-on look at his passion for cooking, community, and regenerative farming. Kimbal Musk is a South African restaurateur, chef, entrepreneur and a board member at Tesla Inc. and SpaceX, companies led by his brother, Elon Musk. Outside of the tech space, Kimbal is the force behind The Kitchen Restaurant Group and co-founder and chairman of Big Green, where he's pioneering outdoor classroom Learning Gardens in schools nationwide. Additionally, Kimbal co-founded Square Roots, an innovative urban farming venture utilizing hydroponic, climate-controlled shipping containers. In our last interview at his newly opened restaurant, The Kitchen, we explored the intersection of technology, regenerative agriculture, and grass-fed cuisine. Today, we unpack Kimbal's passion for food and community. Seriously, we’re not just chatting about technology and longevity here—Kimbal teaches me how best to prepare, serve, and enjoy grass fed steak to perfection. During this live tutorial, we talk about how the energy you put into preparing your food really does impact how it tastes, and his unique perspective on innovation and leadership, gained from working closely with his brother Elon and the teams at Tesla and SpaceX. Then, we explore the highlights of his new cookbook, The Kitchen Cookbook: Cooking for Your Community, a treasure trove of real-food recipes accompanied by easy to follow video tutorials. It’s an incredibly valuable resource for anyone that’s interested in bringing more realness to their food prep and diet.(00:02:14) Embracing Community Through Food(00:18:33) Teaching Kids About Regenerative Farming With Big Green(00:28:56) Try the Kitchen Cookbook for Better Family Meals(00:38:52) Kimbal Musk on Psychedelics: In or Out?(00:43:06) Cooking for Elon Musk(00:47:27) Learn How To Prep & Cook a Beautiful Grass-Fed Steak Live(00:59:22) Kitchen Thoughts on Longevity & Death(01:04:12) Exploring the Link Between Quality Fats & TestosteroneSponsorsApollo Neuro Wearable | Head to apolloneuro.com to save 15% on your Apollo wearable.CAROL Bike | Save $250 on CAROL Bike until January 15th with code DAVE at carolbike.com.ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Organic Revolution: Kimbal Musk’s Mission to Take Down Big Food # 504Big Green: biggreen.org Read: The Kitchen Cookbook by Kimbal MuskThe Kitchen: thekitchen.comRead: Elon Musk by Walter IsaacsonThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Tammi 20241h 9min

Gratitude & Grit: How To Grow in 2024 – Gary Vaynerchuk : 1124

Gratitude & Grit: How To Grow in 2024 – Gary Vaynerchuk : 1124

Today’s guest is not a scientist but a true visionary. Gary Vaynerchuk (aka Gary Vee), is a self-made entrepreneur and digital marketing pioneer. He started his business journey with a lemonade stand at age seven. Now, he’s a prolific content creator, best-selling author, and the co-founder of the massive digital agency VaynerMedia. What I love about Gary is that he leads with integrity, optimism, and, above all, gratitude. He’s a guy of wisdom, not just business—and that’s an important element of what The Human Upgrade is all about.In today’s episode, we explore how entrepreneurship has changed since Gary and I started. We get into how to grow a business in 2024 and Gary’s advice for anyone starting out. His secret to success will surprise you. We talk a lot about gratitude, and how that lens has shaped Gary’s long career and kept him from burning out. Gary also shares his perspective on today’s social media landscape, the importance of kind candor, and why we should look to our elders. No doubt, listening to Gary will inspire you to go after your passions and try that thing you’ve been putting off. In Gary’s words, your happiness is worth fighting for!(00:02:01) Redefining Success as an Entrepreneur(00:07:02) How Gary’s Upbringing Impacted His Success(00:10:32) The Truth About Social Media in 2024(00:14:49) Is Everyone Just Copying Each Other?(00:18:50) Gratitude As the Antidote for Burnout(00:24:11) Championing Wisdom Instead of Youth(00:29:21) Prioritizing Joy Over Riches(00:38:02) Recognizing the Importance of Kind Candor(00:43:08) Reframing Relationships & the Perspectives You Engage With(00:47:17) Leading With Gratitude, Not FearSponsor40 Years of Zen | Go to 40yearsofzen.com/dave to receive an exclusive offer for podcast listeners. ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: garyvaynerchuk.comInstagram: @garyveeTikTok: @garyveeFacebook: Gary Vaynerchuk YouTube: @garyveeX: @garyveeDiscord: VeeFriends The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Tammi 202458min

A Healthy Gut Can Reverse Disease – Dr. Steven Gundry : 1123

A Healthy Gut Can Reverse Disease – Dr. Steven Gundry : 1123

I'm excited to welcome back Dr. Steven Gundry to The Human Upgrade for his sixth appearance, a tribute to his remarkable insights and ongoing research.Dr. Gundry, a true pioneer, is renowned for his books like "The Plant Paradox" and his groundbreaking work on lectins, changing how we understand our body's reaction to food. He's also a top cardiothoracic surgeon and a leader in robotic cardiac surgery, with over two decades of research into the microbiome, using diet and nutrition as key treatment tools. His book, "Unlocking the Keto Code," and his wellness line, GundryMD, have made significant impacts in health and nutrition.In this episode, we dive into cutting-edge research from his new book “Gut Check.” Dr. Gundry discusses the microbiome's connection to disease, and gut health's role in hormone regulation, crucial for mental health during menopause. He'll also share insights on dietary choices, the truth about parasites, and nicotine's unexpected role in longevity.Dr. Gundry's transformative wisdom bridges traditional and alternative medicine. A big thank you to him for another enlightening visit. Thanks for joining us on this journey of discovery!(00:00:22) The Latest Research on How To Reverse Disease(00:10:16) The Link Between Leaky Gut & Gluten(00:16:50) Debunking Blue Zones(00:19:28) What Meat Products You Should Eat & Avoid(00:23:43) The Latest Data on New 5GC, 5AC & Fermented Meat(00:34:27) The Real Issue with Oxalates & How To Boost Your Defenses(00:41:33) How the Microbiome Influences Hormones & Menopause(00:48:10) What Foods Have the Highest Risk for Parasites According to Dr. Gundry(00:55:11) Benefits & Risks of Berberine(00:58:21) The Surprising Truth About Nicotine & Longevity(01:09:11) The Downside to Too Much Olive OilSponsorsARMRA | Visit tryarmra.com and use the code DAVE to get 15% off your first order.Leela Q | Visit leelaq.com/dave and get a 10% discount on LeelaQ products. ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Read: Gut Check by Dr. Steven GundryWebsite: drgundry.comPodcast: The Dr. Gundry PodcastKeto Gets an Upgrade – Dr. Steven Gundry #912How to Identify Your Energy Blockers and Beat Fatigue – Dr. Steven Gundry with Dave Asprey – #803 How Foods are Harming Your Kids – Steven Gundry, M.D. – #649Healthy Aging Begins and Ends in the Gut – Dr. Steven Gundry #604How Nutrition Can Reverse Disease and the Impact of Lectins – Dr. Steven Gundry – #417The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Tammi 20241h 15min

NAD+: A Quantum Leap in Biohacking – Dr. Gregory Kelly : 1122

NAD+: A Quantum Leap in Biohacking – Dr. Gregory Kelly : 1122

On today’s Upgrade Spotlight episode, we’re talking all about NAD+. In the biohacking world, everyone and their mother has heard of NMN and NAD+, but there’s more to it than meets the eye. To get into the nitty gritty of NAD+, we’re joined by Dr. Gregory Kelly, a naturopathic physician and the lead product formulator at Neurohacker Collective, also known as Qualia. I’m an advisor to the company, and they do fantastic and innovative work in the longevity space. Their NAD+ supplement is a quantum leap in biohacking and a no-brainer to add to your stack. In today’s episode, Dr. Kelly explains what NAD is and why it’s essential for longevity, cognition, energy levels, and athletic performance. We talk about the differences between NR, NMN, and Niacinamide. We also explore the most efficient way to get NAD. Is an IV worth the money or will supplements give you more bang for your buck? Plus, Dr. Kelly breaks down exactly what’s included—and not included—in the Qualia NAD+ formula. I’ve been a major proponent of NAD for more than 10 years, but I don’t like to spend all my time and money getting it. If you feel the same, you’re going to want to tune into this episode. (00:01:55) What Is NAD & Why Do We Care?(00:06:19) The Most Efficient Way To Get NAD(00:09:55) Sirtuin’s Superpowers (00:14:42) The Qualia NAD+ Formula (00:22:37) The Buzz on Coffee Berry (00:25:53) When Is the Best Time To Take NAD+? (00:30:01) NAD+ in Clinical Trials (00:34:16) What’s NOT in the Qualia Supplement (00:38:02) A Quantum Leap for Biohacking Episode SponsorNeurohacker | Boost YOUR NAD+ up to 50%* + GET 50% OFF go to neurohacker.com/DAVENAD.ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Visit neurohacker.com/davenad to save 50% on Qualia NAD+ by Neurohacker Neurohacker Collective: neurohacker.comNeurohacker Collective Instagram: @neurohacker Linkedin: Gregory Kelly The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Tammi 202441min

How to Relentlessly Prioritize Your Life – Jesse Itzler : 1121

How to Relentlessly Prioritize Your Life – Jesse Itzler : 1121

Today, we take a look into the mindset and habits of successful entrepreneurs and mastering the art of organization for success, topics that today’s guest has totally mastered. Jesse Itzler has an impressive background with a bachelor's degree from American University and a further degree in justice, law, and society. His resume as an entrepreneur is also quite impressive, co-founding Marquis Jet, the world's largest private jet card company, which was later sold to Berkshire Hathaway/NetJets. Beyond this, he's partnered with Zico coconut water, selling it to The Coca-Cola Company, and has ventured into the music industry, co-writing Billboard Top 100 hits and co-founding Alphabet City Sports Records. Jesse is also an acclaimed triathlete and author, with his book, Living with a Seal, becoming a New York Times bestseller.As we step into the early days of 2024, this episode is all about providing you with clear, direct methods to upgrade your life across various facets—work, fitness, and personal development. Tune in as I compare and contrast my organizational methods with Jesse's, the goal being to introduce you to strategies that resonate with you and align with your personality. You'll gain insights into how Jesse efficiently prioritizes his calendar and the skills needed to outperform competition when you’re starting out in business. We also explore habits and tools for staying physically and mentally young, our favorite biohacks, my personal excitement in the field of longevity, and ways to structure your life for maximum return on investment, both in terms of monetary success and happiness. While our methods differ in some areas, our objective is the same: to live a life with minimal regrets, whether you reach 80 or 180 years old. Join us as we discuss the habits of successful entrepreneurs—both from our experience and learning from others at the top of their game—and discover practical ways to implement these lessons into your life.(00:00:20) The Secret to Jesse’s Success in Business & Triathlons(00:05:10) How Jesse Organizes His Life & Implements New Habits(00:22:49) Structuring Support Systems & Early Hires(00:32:41) Lessons From Living With a Seal & Monks(00:48:19) What Biohacks Dave Is Most Excited About(00:54:21) How To Organize Your Time Efficiently(01:01:54) The Mindset & Habits of Successful Entrepreneurs(01:10:34) The Recipe for a Fulfilling Life(01:18:46) Dave’s Top Tools for LongevitySponsor: https://www.viome.com/dave to save $150 full body intelligence test.ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: jesseitzler.comInstagram: @jesseitzlerTikTok: @jesseitzlerYouTube: Jesse ItzlerLinkedin: Jesse ItzlerThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Tammi 20241h 25min

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