298 | Jeff Lichtman on the Wiring Diagram of the Brain

298 | Jeff Lichtman on the Wiring Diagram of the Brain

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

Jaksot(415)

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115 | Netta Engelhardt on Black Hole Information, Wormholes, and Quantum Gravity

Stephen Hawking made a number of memorable contributions to physics, but perhaps his greatest was a puzzle: what happens to information that falls into a black hole? The question sits squarely at the ...

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114 | Angela Chen on Asexuality in a Sex-Preoccupied World

114 | Angela Chen on Asexuality in a Sex-Preoccupied World

Sexuality is, and always has been, a topic that is endlessly fascinating but also contentious. You might think that asexuality would be more straightforward, but you'd be wrong. Asexual people, or "ac...

14 Syys 20201h 8min

113 | Cailin O'Connor on Game Theory, Evolution, and the Origins of Unfairness

113 | Cailin O'Connor on Game Theory, Evolution, and the Origins of Unfairness

You can't always get what you want, as a wise person once said. But we do try, even when someone else wants the same thing. Our lives as people, and the evolution of other animals over time, are shape...

7 Syys 20201h 19min

112 | Fyodor Urnov on Gene Editing, CRISPR, and Human Engineering

112 | Fyodor Urnov on Gene Editing, CRISPR, and Human Engineering

Not too long ago nobody carried a mobile phone; now almost everybody does. That's the kind of rate of rapid progress we're seeing with our ability to directly edit genomes. With the use of CRISPR-Cas9...

31 Elo 20201h 20min

111 | Nick Bostrom on Anthropic Selection and Living in a Simulation

111 | Nick Bostrom on Anthropic Selection and Living in a Simulation

Human civilization is only a few thousand years old (depending on how we count). So if civilization will ultimately last for millions of years, it could be considered surprising that we've found ourse...

24 Elo 20201h 20min

110 | Neil Johnson on Complexity, Conflict, and Infodemiology

110 | Neil Johnson on Complexity, Conflict, and Infodemiology

Physicists have traditionally simplified systems as much as possible, in order to shed light on fundamental properties. But small, simple parts build up into large, complex wholes. Are there new rules...

17 Elo 20201h 23min

109 | Jason Torchinsky on Our Self-Driving Future

109 | Jason Torchinsky on Our Self-Driving Future

It's easy to foresee that technological progress will change how we live; it's much harder to anticipate exactly how. Self-driving cars represent an enormous technological challenge, but one that is p...

10 Elo 20201h 18min

108 | Carl Bergstrom on Information, Disinformation, and Bullshit

108 | Carl Bergstrom on Information, Disinformation, and Bullshit

We are living, in case you haven't noticed, in a world full of bullshit. It's hard to say whether the amount is truly increasing, but it seems that everywhere you look someone is trying to convince yo...

3 Elo 20201h 24min

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