298 | Jeff Lichtman on the Wiring Diagram of the Brain

298 | Jeff Lichtman on the Wiring Diagram of the Brain

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

Jaksot(415)

84 | Suresh Naidu on Capitalism, Monopsony, and Inequality

84 | Suresh Naidu on Capitalism, Monopsony, and Inequality

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83 | Kwame Anthony Appiah on Identity, Stories, and Cosmopolitanism

83 | Kwame Anthony Appiah on Identity, Stories, and Cosmopolitanism

The Greek statesman Demosthenes is credited with saying "I am a citizen of the world," and the idea that we should take a cosmopolitan view of our common humanity is a compelling one. Not everyone agr...

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82 | Robin Carhart-Harris on Psychedelics and the Brain

82 | Robin Carhart-Harris on Psychedelics and the Brain

The Convention on Psychotropic Substances was a 1971 United Nations treaty that placed strong restrictions on the use of psychedelic drugs — not only on personal use, but medical and scientific resear...

3 Helmi 20201h 17min

81 | Ezra Klein on Politics, Polarization, and Identity

81 | Ezra Klein on Politics, Polarization, and Identity

People have always disagreed about politics, passionately and sometimes even violently. But in certain historical moments these disagreements were distributed without strong correlations, so that any ...

27 Tammi 20201h 21min

80 | Jenann Ismael on Connecting Physics to the World of Experience

80 | Jenann Ismael on Connecting Physics to the World of Experience

Physics is simple; people are complicated. But even people are ultimately physical systems, made of particles and forces that follow the rules of the Core Theory. How do we bridge the gap from one kin...

20 Tammi 20201h 26min

79 | Sara Imari Walker on Information and the Origin of Life

79 | Sara Imari Walker on Information and the Origin of Life

We are all alive, but "life" is something we struggle to understand. How do we distinguish a "living organism" from an emergent dynamical system like a hurricane, or a resource-consuming chemical reac...

13 Tammi 20201h 23min

78 | Daniel Dennett on Minds, Patterns, and the Scientific Image

78 | Daniel Dennett on Minds, Patterns, and the Scientific Image

Wilfrid Sellars described the task of philosophy as explaining how things, in the broadest sense of term, hang together, in the broadest sense of the term. (Substitute "exploring" for "explaining" and...

6 Tammi 20202h 1min

Holiday Message 2019: On Publishing Books

Holiday Message 2019: On Publishing Books

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