298 | Jeff Lichtman on the Wiring Diagram of the Brain

298 | Jeff Lichtman on the Wiring Diagram of the Brain

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

Jaksot(415)

308 | Alison Gopnik on Children, AI, and Modes of Thinking

308 | Alison Gopnik on Children, AI, and Modes of Thinking

We often study cognition in other species, in part to learn about modes of thinking that are different from our own. Today's guest, psychologist/philosopher Alison Gopnik, argues that we needn't look ...

17 Maalis 20251h 9min

AMA | March 2025

AMA | March 2025

Welcome to the March 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patre...

10 Maalis 20252h 58min

307 | Kevin Peterson on the Theory of Cocktails

307 | Kevin Peterson on the Theory of Cocktails

A lot of science goes into crafting the perfect cocktail. Balancing sweet and bitter notes, providing the right amount of aeration and dilution, getting it to just the right temperature and keeping it...

3 Maalis 20251h 16min

306 | Helen Czerski on Our Energetic Oceans

306 | Helen Czerski on Our Energetic Oceans

It is commonplace to refer to the Earth's oceans as vast and largely unexplored. But we do understand some aspects, and improving that understanding is crucial to ensuring the continued viability and ...

24 Helmi 20251h 12min

305 | Lilliana Mason on Polarization and Political Psychology

305 | Lilliana Mason on Polarization and Political Psychology

Political outcomes would be relatively simple to predict and understand if only people were well-informed, entirely rational, and perfectly self-interested. Alas, real human beings are messy, emotiona...

17 Helmi 20251h 17min

Bonus | Cuts to Science Funding and Why They Matter

Bonus | Cuts to Science Funding and Why They Matter

The Trump administration, led by Elon Musk and his Department of Government Efficiency, has proposed sweeping cuts to spending on science research here in the US, in particular at the National Institu...

12 Helmi 20251h 10min

304 | James Evans on Innovation, Consolidation, and the Science of Science

304 | James Evans on Innovation, Consolidation, and the Science of Science

It is a feature of many human activities - sports, cooking, music, interpersonal relations - that being able to do them well doesn't necessarily mean you can accurately describe how to do them well. S...

10 Helmi 20251h 16min

303 | AMA | February 2025

303 | AMA | February 2025

Welcome to the February 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Pa...

3 Helmi 20253h 44min

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