Dravet syndrome and the influence of the genome: Dr. Sanjay Sisodiya

Dravet syndrome and the influence of the genome: Dr. Sanjay Sisodiya

Send comments and feedback Dravet syndrome is a rare, severe epilepsy caused by changes in a gene called SCN1A. The changes cause the gene to stop functioning normally. But not everyone with this type of genetic change develops Dravet syndrome, and people with Dravet also have a wide range of clinical characteristics, which can't be fully explained by these changes. What else is going on? We spoke with Dr. Sanjay Sisodiya about a recent publication on genomic influences in Dravet syndrome. T...

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Drug-resistant epilepsy: Dr. Patrick Kwan

Drug-resistant epilepsy: Dr. Patrick Kwan

Send comments and feedback About one-third of people with epilepsy will continue having seizures despite medications. What is the clinical definition of drug-resistant epilepsy? Why does it occur, and...

24 Marras 202532min

Normalizing depression in epilepsy: Screening, diagnosis, treatment - Dr. Rosa Michaelis

Normalizing depression in epilepsy: Screening, diagnosis, treatment - Dr. Rosa Michaelis

Send comments and feedback Nearly 1 in 4 people with epilepsy experiences depression, which affects quality of life, seizure control, and adherence to treatment. Depressive symptoms - including suicid...

10 Marras 202522min

A novel patient-reported outcome measure for epilepsy: The impacts of seizures and treatment

A novel patient-reported outcome measure for epilepsy: The impacts of seizures and treatment

Send comments and feedback Is there a fast, simple way to measure whether someone with epilepsy is doing "better" or "worse" compared with a past clinic visit? Not really. Seizure count is often consi...

27 Loka 202518min

Social work in epilepsy: Closing the treatment gap and improving quality of life - Dr. Rugare Mugumbate

Social work in epilepsy: Closing the treatment gap and improving quality of life - Dr. Rugare Mugumbate

Send comments and feedback Closing the epilepsy treatment gap relies heavily on social and cultural acceptance of epilepsy as a brain disorder that can be managed with medication or other therapies. D...

13 Loka 202530min

Somatic genetic epilepsies: Dr. Christian Bosselmann

Somatic genetic epilepsies: Dr. Christian Bosselmann

Send comments and feedback Somatic genetic epilepsies arise from mutations that occur early in fetal development. They are usually only detectable by genetic sequencing of tissue. For these epilepsies...

29 Syys 202531min

Research recap: Empiric immunotherapy for highly refractory epilepsy: Dr. Elisabeth Doran

Research recap: Empiric immunotherapy for highly refractory epilepsy: Dr. Elisabeth Doran

Send comments and feedback In a retrospective study of 31 patients with highly refractory epilepsy, 29% had more than a 50% reduction in seizures for at least 12 months after being treated with immuno...

8 Syys 202512min

Genetic testing: Variants of uncertain significance (VUS) - Dr. Gemma Carvill

Genetic testing: Variants of uncertain significance (VUS) - Dr. Gemma Carvill

Send comments and feedback What are variants of uncertain significance (VUS) in epilepsy genetic testing? How are they defined, and can those definitions change over time? Sharp Waves talks with Dr. G...

18 Elo 202534min

What's new in status epilepticus: Dr. Eugen Trinka

What's new in status epilepticus: Dr. Eugen Trinka

Send comments and feedback This episode covers a wide scope of issues, including treatment options, treatment response, prognosis and the role of seizures versus the underlying etiology, most common e...

4 Elo 202546min

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