121. What is Naturalistic Research? with Dr Matthew X. Lowe

121. What is Naturalistic Research? with Dr Matthew X. Lowe

A conversation between Prof David Nutt and research scientist Dr Matthew X. Lowe.


Dr Matthew X. Lowe PhD is Director of Research for Realm of Caring and Executive Director for Unlimited Sciences, a not-for-profit, observational research organisation with a focus on cannabis and psychedelic use by underrepresented population groups and a toll-free info line providing evidence-based support for anyone using psychedelics.


In this episode, they discuss the vital role of observational and longitudinal research when it comes to the medicalisation of cannabis and psychedelics — and the importance for safetyof bringing real-world data into our collective knowledge base.


They start with the genesis of Realm of Caring and Unlimited Sciences. Both organisations were conceived following first-hand experience of the banned compounds they research being profoundly medically transformative — inspiring co-founder Heather Jackson to grow related research and make it freely available to all who stand to benefit from such education. The origin stories of the organisations are followed by Dr Lowe’s personal route to his current research role and the roots of his passion for pursuing psychedelic research questions.


Their focus then shifts to the present day with a comparison of roadblocks and red tape around researching cannabis and psychedelics in the UK and the US, noting the pioneering role that parents so often play in advocating for research into medicinal cannabis. Next comes a deeper exploration of specific properties of psychedelics that relate to their potential therapeutic applications, including their anti-addictive nature and positive habit-forming potential resulting from the neuroplastic window they potentiate — Unlimited Sciences has conducted the world’s largest naturalistic study on psilocybin use with further papers coming out on these implications.


For the remainder of the episode, Prof David Nutt and Dr Matthew Lowe go into specifics on several key projects from Realm of Caring and Unlimited Sciences, including:

- The Realm of Caring Observational Research Registry, being done in collaboration with Johns Hopkins Cannabis Science Laboratory. This ongoing research is an IRB-approved online survey study looking at the effects on a variety of health conditions, in people who do and do not use cannabis. It is open to everyone in the world with internet access.

- The Cannabis and Health Research Initiative (CHRI), another collaboration between Johns Hopkins and Realm of Caring, examining the patient-level impact of therapeutic cannabis use, through data collection and dissemination — aiming to aid clinical decision making and policymaking.


And finally, two ceremonial research projects looking at ayahuasca, foregrounding the role of community and context in ceremonial psychedelic experiences — both exemplifying Unlimited Sciences’ diversification of the evidence base on psychedelics by collecting real world data on underrepresented population groups:

- With subjects who were Arabic-speaking women, a study exploring the psychological benefits of ayahuasca for refugees — with DrugScience collaborator Dr Robin Carhart-Harris.

- And, currently in data analysis, with first results set to release in 2025, an IRB-approved study about ayahuasca use in the LGBTQIA+ community in collaboration with Costa Rica plant medicine retreat Jungle Gayborhood, with an emphasis on the importance of set and setting being truly safe spaces in the sense of meeting the specific needs of participants involved.


Find out more about Dr Matthew X. Lowe and Unlimited Sciences below!


Dr Matthew X. Lowe


Realm of Caring


Unlimited Sciences


The Psychedelic Info Line


Charlotte’s Web, Charlotte Figi and Realm of Caring


Realm of Caring’s research library


Long-term CBD study (Realm of Caring)


Observational Research Registry (Realm of Caring)


World’s largest naturalistic study on psilocybin use
(Unlimited Sciences)


Psychological benefits of ayahuasca for refugees
(Unlimited Sciences)


Jungle Gayborhood

The LGBTQIA+ study

★ Support this podcast ★

Jaksot(142)

115. Six years of medical cannabis in the UK with Dr Leon Barron, Dr Callie Seaman and Michael Sassano

115. Six years of medical cannabis in the UK with Dr Leon Barron, Dr Callie Seaman and Michael Sassano

What is the UK medical cannabis industry looking like in 2024?We are 6 years on from legalisation of cannabis-based medical products in the UK and although many patients have now been able to access these products, many others are still struggling to get access. In this episode of the Drug Science podcast, Prof. David Nutt is joined by three leading experts in cannabis science and the evolving landscape of regulation. Dr. Callie Seaman, Dr. Leon Barron, and Michael Sassano share their insights into the future of cannabis as a medicine, the current regulatory environment, and the scientific innovations driving the industry forwardCannabis Industry CouncilMedical Cannabis Working Group  SOMAI Pharmaceuticals Medical Cannabis Clinicians SocietyLondon Resilience Clinic German medical cannabis market NHS Cannabis-based products for medicinal useCost effectiveness paperHHS report This episode has been supported by the Cannabis Industry Council  ★ Support this podcast ★

23 Loka 202446min

114. Chemsex with Darren Murphy

114. Chemsex with Darren Murphy

In this episode, we meet with Darren Murphy, a Chemsex Specialist Practitioner at Forward Leeds, to discuss chemsex, addiction, as well as addressing the link with the LGBTQ+ community. Darren shares his personal journey, navigating the challenges of drug addiction and everything which came with it. Realising the limited support available for people engaging in chemsex, Darren shares how he uses his experiences to help others overcome similar struggles.   ChemSex and Being SaferMethamphetaminemephedroneGHBPoppersCocaineMdmaKetamineEating disorderHIVNarcotics AnonymousSupport the podcast ★ Support this podcast ★

9 Loka 202452min

113. Psychiatrists and Curanderos with Dr Simon Ruffell

113. Psychiatrists and Curanderos with Dr Simon Ruffell

In this episode, we sit down with Dr. Simon Ruffell, a psychiatrist and ayahuasca researcher with extensive experience working with Indigenous communities in the Amazon Basin. He discusses the potential of Indigenous medicines to complement Western psychiatric care and reduce relapse rates. Dr. Ruffell compares Western and Indigenous approaches to using spiritual plants, addressing the ongoing debate about how to respectfully integrate Indigenous medicine into Western healthcare as well as highlighting the key differences between commercial ayahuasca retreats and authentic Indigenous practices. Lastly, he discusses aspects of Shipibo culture and a journey into Shamanism.   AyahuascaDMTPsilocybinPsychosisRevolving door syndromeShipiboHeroic HeartsSupport the PodcastDr Simon RuffellOnaya HealthOnaya ScienceMind over matterParticipation in an indigenous Amazonian-led ayahuasca retreat associated with increases in nature relatednessCeremonial Ayahuasca in Amazonian RetreatsModulatory effects of ayahuasca on personality structure in a traditional framework ★ Support this podcast ★

25 Syys 20241h 3min

112. Parties, drugs and young people with Dr Karenza Moore

112. Parties, drugs and young people with Dr Karenza Moore

In this episode, we meet with Dr Karenza Moore as she discusses changes in drug trends in the UK, focusing on the motivations, risks, and patterns of drug use, particularly among young people. Karenza identifies trends in drug use, including the impact of the lockdown on substance abuse. She also examines various drug trends within dance music culture, which leads to a discussion of safer partying practices, with a particular focus on the LGBT community and the importance of staying safe during a night out.  Finally she addresses the challenges of conducting research in this area and outlines strategies for overcoming these barriers to gain a comprehensive understanding of substance use. KetamineMDMAMephedroneReleaseTransformBeckleys foundationSupport the podcast ★ Support this podcast ★

11 Syys 20241h 1min

111. OCD and Psychedelics with Rose Cartwright

111. OCD and Psychedelics with Rose Cartwright

In this episode, Prof Nutt meets with Rose Cartwright as she discusses the impact of psychedelics on her Obsessive-compulsive disorder (OCD). She reflects on some of the common misconceptions around OCD as well as the impact diagnosis and traditional treatment had on her life. Throughout the episode, she reflects on her own psychedelic experiences, mistakes made along the way and the steps she would have taken differently going into this with the knowledge she has today.Rose Cartwright is a screenwriter whose memoir, Pure, about her life with intrusive sexual thoughts, was adapted for Channel 4. Her revolutionary new memoir, The Maps We Carry, reveals how the failure of the mental health system to cure her OCD led her to radical action. While she explored her trauma through a series of mind-bending psychedelic trips, she began to interrogate our dominant medical paradigm. Her writing about psychedelics, consciousness and mental health has also been published in The Face, Vice and the Guardian. Rose is a writer on the Netflix adaptation of Liu Cixin’s The Three Body Problem.The Maps We Carry Rose Cartwright OCDBulimia PTSDPure Intrusive thoughtsPsychodynamic therapyPerson centred therapyMDMA PsilocybinSupport the podcast ★ Support this podcast ★

28 Elo 202444min

110. Ancient Wisdom in the Modern World with Satya

110. Ancient Wisdom in the Modern World with Satya

In this episode, we meet with Satya, a consciousness activist, who has been entirely dedicated to the expansion and evolution of human consciousness for 15 years. Throughout this time, she has facilitated retreats for over 63,000 people around the world, with profound processes of transformation. Satya is the founder of Working With Satya and of the Awareness Facilitator School, that is currently training facilitators with the method she has developed, uniting modern therapies with science, meditation and ancient wisdom.  She discusses the process of her work through a wide range of transformational processes, with a special focus on combining ancient rituals with contemporary therapeutic techniques. Satya shares how her personal healing journey, following sexual abuse, led her to discover the transformative power of Ayahuasca. Inspired by this experience, she became passionate about sharing this sacred medicine and supporting others on their own paths to healing. Working With Psilocybin - Training Course AyahuascaPsilocybinmescalineWorking with SatyaAyahuasca retreatTraumaPTSD in Veterans Indigenous ethics in psychedelic workSupport the podcast ★ Support this podcast ★

14 Elo 202449min

109. Prisons and Drugs with Prof Karen Duke and Prof Susanne MacGregor

109. Prisons and Drugs with Prof Karen Duke and Prof Susanne MacGregor

In this episode, we meet with Prof Susanne MacGregor and Prof Karen Duke to explore the issues surrounding drug use in prisons. They discuss the ways vulnerable inmates can be targeted by gangs, as well as how various aspects of the prison environment can increase the potential harms of psychoactive substances.  The risk matrix: Drug-related deaths in prisons in England and Wales, 2015–2020 Responding to ‘wicked problems’: policy and governance on drug-related deaths in English and Welsh prisons, 2015-2020Producing the ‘problem’ of new psychoactive substances (NPS) in English prisons‘Keeping a lid on it’: Exploring ‘problematisations’ of prescribed medication in prisons in the UK 'Risk, Intoxication and Death: contemporary media framings of drug-related deathsACMD report: ageing cohort of drug usersCity roads PPO Pregabalin Cannabis Synthetic cannabis EcstasyHeroin HIVFentanyl ADHD Rory Stewart 10 Prisons Project Antisocial personality disorder Support the podcast ★ Support this podcast ★

31 Heinä 202454min

108. Psychedelic Education in the UK with Dr Duncan Still

108. Psychedelic Education in the UK with Dr Duncan Still

In this episode, David Nutt meets with Dr Duncan Still, a GP with significant interest in integrative medicine. He highlights the importance of adopting a holistic approach when providing support for patients and connecting traditional medicine with modern medicine as opposed to discounting it. Duncan explains how this holistic and integrative approach led to him becoming involved in psychedelic retreats and explains the process participants will undergo. PsyEduUK AcupuncturePsilocybinMDMAAustralia MDMA and psilocybinMind medicine AustraliaNature connectednessJames HawkinsSupport the Podcast ★ Support this podcast ★

17 Heinä 202448min

Suosittua kategoriassa Tiede

rss-mita-tulisi-tietaa
utelias-mieli
tiedekulma-podcast
rss-poliisin-mieli
rss-lihavuudesta-podcast
rss-duodecim-lehti
rss-tiedetta-vai-tarinaa
docemilia
hippokrateen-vastaanotolla
rss-ammamafia
rss-lapsuuden-rakentajat-podcast
filocast-filosofian-perusteet
radio-antro
rss-ranskaa-raakana
rss-totta-vai-tuubaa
rss-radplus
rss-yleislaakarin-sydanaanet
rss-taivaanranta
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita