2025 Biohacking State of the Union: Master Supplementation Guide with Dr. Sandra Kaufmann : 1243

2025 Biohacking State of the Union: Master Supplementation Guide with Dr. Sandra Kaufmann : 1243

What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive?

Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can bend the rules of biology to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride.

From downing Diet Cokes to defying traditional medical dogma, she’s rewritten the playbook on anti-aging with her Seven Tenets of Aging. Together, she and Dave dive into everything from molecular hacks for outsmarting junk food to unlocking the secret power of your mitochondria, DNA, and circadian rhythms. This episode goes beyond the surface with mind-blowing insights, hilarious moments, and actionable steps to take your health (and your fun) to the next level.

What You’ll Learn:

• The Seven Tenets of Aging and how they’ll change your approach to health

• Why indulging in “bad” habits doesn’t have to sabotage your longevity

• Biochemical secrets to combat oxidative stress, glycation, and cellular junk

• The real story behind NAD, circadian rhythms, and the tools for better sleep

• How to create a personalized health plan that’s sustainable, effective—and fun


Resources:

Supplement Protocol One-Sheet for this episode: https://www.instagram.com/dave.asprey/?hl=en

2025 Biohacking Conference: https://biohackingconference.com/2025

Kaufmann Protocol Website: https://kaufmannprotocol.com

Sandra Kaufmann’s Book – Why We Age and How to Stop It: https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047

Sandra Kaufmann’s Instagram: https://www.instagram.com/kaufmannantiaging/?hl=en

Danger Coffee: https://dangercoffee.com

Dave Asprey’s Website: https://daveasprey.com

Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books

Dave Asprey’s Linktree: https://linktr.ee/daveasprey

Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

Own an Upgrade Labs: https://ownanupgradelabs.com

Upgrade Labs: https://upgradelabs.com

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com


SPONSORS:

Leela Quantum | Head to https://leelaq.com/DAVE for 10% off.

Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.


Timestamps:

00:00 Trailer

00:45 Guest Introduction

02:30 Longevity Insights

04:22 Personal Stories

08:00 Pharmaceuticals

12:26 Diet and Lifestyle

18:19 Seven Tenets

22:04 Sleep and Circadian Rhythms

26:41 NAD and Supplements

37:46 Blood Sugar and AGEs

47:09 Microcirculation

49:08 NRS and Imports

49:18 Celebrex Medication

50:03 Celebrex Benefits

50:41 Alzheimer’s and Celebrex

51:28 Antioxidants

54:26 Stem Cells and Exosomes

58:03 Laser Skin Treatments

01:07:34 Hormones and Longevity

01:20:03 Lithium for Mood

01:27:45 Gender and Longevity

01:32:39 Final Thoughts

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