#169 MGUS to Multiple Myeloma Diagnostics and Counseling: 5 Pearls Segment

#169 MGUS to Multiple Myeloma Diagnostics and Counseling: 5 Pearls Segment

SPEP vs. UPEP? What does it tell you and not tell you? What is the role for immunofixation and free light chains in diagnosis? Learn about paraneoplastic antibodies with MGCS and its renal, neurologic, and dermatologic manifestations!

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Behind The Scenes Youtube Interview with Dr. Vincent Rajkumar

Transcript and Show Notes

Timestamps:

(01:26) | Pearl 1: What is a monoclonal gammopathy? What is our expected clinical presentation?

(10:12) | Pearl 2: What is our initial workup? Understanding SPEP, Immunofixation, and Free Light Chains

(24:13) | Pearl 3: Do we need urine testing? When urine testing is necessary and when it is not.

(26:26) | Pearl 4: How should we differentiate monoclonal gammopathies? The continuum of MGUS, SMM, and MM.

(41:35) | Pearl 5: Demystifying Monoclonal gammopathy of clinical significance (MGCS)


Tags: CoreIM, Internal Medicine, ClinicalPearls, Medical Education, IMCore, hospitalist, physician assistant, nurse practitioner, medical student, internal medicine



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Jaksot(212)

#188 Orthostatic Hypotension Part 2: Gray Matters Segment

#188 Orthostatic Hypotension Part 2: Gray Matters Segment

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#187 Orthostatic Hypotension Part 1: Gray Matters Segment

#187 Orthostatic Hypotension Part 1: Gray Matters Segment

Learn specific, practical ways to counsel patients on non-pharmacologic interventions. What is our goal with OH treatment? Is it the blood pressure number that matters? How do we avoid missing neuroge...

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#186 Pneumothorax: 5 Pearls Segment

#186 Pneumothorax: 5 Pearls Segment

Next time you’re squinting at a chest tube, feel confident you know exactly what to look for and why. Hear it explained in a way that really sticks!🔹 Sponsor: Oakstone CME’s ACP MKSAP Audio Companion...

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#185 Neutropenia: 5 Pearls Segment

#185 Neutropenia: 5 Pearls Segment

How do you work up neutropenia? When is neutropenia benign? When do neutrophils recover? How can you diagnose neutropenic fever in the first 15 minutes and start antibiotics in the first 60 minutes? D...

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#184 Stories for the Feels

#184 Stories for the Feels

Have a good laugh and reflect deeply with these three stories that hit the feels in different ways.If you'd love to hear more stories from Dr. Maria Rosasco, check out some of her other appearances on...

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#183 Diagnose the Clinician: Hoofbeats Segment

#183 Diagnose the Clinician: Hoofbeats Segment

What went wrong? What were the reasoning or contextual missteps that led us astray?🔹 Sponsor: NEJM Fellowship Program, click here to learn more and/or apply! Due Aug 1, 2025🔹 Transcript and Show Not...

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#182 Pleural Effusions: 5 Pearls Segment

#182 Pleural Effusions: 5 Pearls Segment

Imaging Pearls | (01:12)Deciding on Thoracentesis | (04:00)Light’s Criteria and Pseudoexudates | (07:00)Pleural Fluid Studies: pH and Cell Differential | (16:56)Diagnosing and Treating Parapneumonic E...

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#181 July Stories 3.0

#181 July Stories 3.0

Listen for some good laughs and relatable stories!In this episode, we share raw and real stories from July — from rapid responses to unexpected kindness — and reflect on the emotional weight of starti...

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