Who visits raccoon latrines, and boosting cancer therapy with gut microbes

Who visits raccoon latrines, and boosting cancer therapy with gut microbes

David Grimm—online news editor for Science—talks with Sarah Crespi about a long-term project monitoring raccoon latrines in California. What influence do these wild bathrooms have on the ecosystem? Sarah also interviews Christian Jobin of the University of Florida in Gainesville about his Perspective on three papers linking the success of cancer immunotherapy with microbes in the gut—it turns out which bacteria live in a cancer patient’s intestines can predict their response to this cutting-edge cancer treatment. Read the related papers: Routy et al., Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors, Science 2018 Gopalakrishnan et al., Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients, Science 2018 Matson et al., The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients, Science 2018 aan4236 Listen to previous podcasts. [Image: cuatrok77/Flickr; Music: Jeffrey Cook] Learn more about your ad choices. Visit megaphone.fm/adchoices

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The Normals | Episode 1

The Normals | Episode 1

How do we know what's normal in a person? In the early 1950s, the National Institutes of Health (NIH) set out to do something unprecedented. It wanted to start studying normal humans on a grand scale....

7 Huhti 23min

Resolving the dispute over the speed of the expanding universe, and seeking new drug targets for cognitive dysfunction

Resolving the dispute over the speed of the expanding universe, and seeking new drug targets for cognitive dysfunction

First up on the podcast, a new path to calculating the Hubble constant. This value for the universe’s speed of expansion is typically determined in one of two ways, one favored by cosmologists, the ot...

2 Huhti 33min

Resurrection plants, Project Hail Mary, and the trouble with sycophantic AI

Resurrection plants, Project Hail Mary, and the trouble with sycophantic AI

First up on the podcast, Deputy News Editor Martin Enserink talks about so-called resurrection plants. These specialized plants can survive up to 95% water loss, whereas most plants struggle when thei...

26 Maalis 36min

Rethinking the peopling of the Americas, and the best ways to get groundwater back

Rethinking the peopling of the Americas, and the best ways to get groundwater back

First up on the podcast, we discuss a finding that’s likely to reignite debate over how humans first spread through the Americas. In the late 1990s, a site in southern Chile called Monte Verde forced ...

19 Maalis 33min

What Alaska’s eroding coastline says about Earth’s future, and how Yellowstone ravens use their smarts to find wolf kills

What Alaska’s eroding coastline says about Earth’s future, and how Yellowstone ravens use their smarts to find wolf kills

First up on the podcast, freelance journalist Evan Howell traveled to Cape Blossom, Alaska, where the receding coastline has revealed an ancient trove of glacial ice that may have survived for 350,000...

12 Maalis 42min

An alleged nuclear blast may reignite weapons testing, and who owns the Moon

An alleged nuclear blast may reignite weapons testing, and who owns the Moon

First up on the podcast, a peek into the roiling seas of U.S. science policy. ScienceInsider Editor Jocelyn Kaiser talks about shifting leadership at the National Science Foundation and the Cente...

5 Maalis 38min

Tropical birds’ ‘silent spring,’ and mapping people’s brains during surgery

Tropical birds’ ‘silent spring,’ and mapping people’s brains during surgery

First up on the podcast, producer Meagan Cantwell talks to Contributing Correspondent Warren Cornwall about his visit to Brazil, where he observed firsthand what it takes for researchers to understand...

26 Helmi 32min

Matching sounds to shapes, and stories from the AAAS annual meeting

Matching sounds to shapes, and stories from the AAAS annual meeting

First up on the podcast, Newsletter Editor Christie Wilcox, Associate Online News Editor Michael Greshko, and intern Perri Thaler share their experiences from the AAAS annual meeting in Phoenix. Chri...

19 Helmi 41min

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