Science Magazine Podcast12 Touko 2022

Fixing fat bubbles for vaccines, and preventing pain from turning chronic

On this week’s show: Lipid nanoparticles served us well as tiny taxis delivering millions of mRNA vaccines against COVID-19, but they aren’t optimized—yet, and why we might need inflammation to stop chronic pain The messenger RNA payload of the mRNA vaccines against SARS-CoV-2 is wrapped up in little fatty packets called lipid nanoparticles (LNPs). These fat bubbles were originally designed for something much different—carrying molecules into cells to silence genes. But they were useful and we were in a hurry, so not much was changed about them when they were pressed into service against COVID-19. Science journalist Elie Dolgin talks with host Sarah Crespi about ongoing efforts to improve LNPs as a delivery system for mRNA vaccines and therapeutic treatments. Next on the show, we hear about “pain chronification.” Have you ever thought about chronic pain? What happens in the body when it heals—no specific thing is broken—but the pain never subsides? Sarah chats with Luda Diatchenko, professor on the faculties of medicine and dentistry at McGill University, about her Science Translational Medicine paper on the need for inflammation to prevent pain chronification. This week’s episode was produced with help from Podigy. [Image: V. Altounian/Science; Music: Jeffrey Cook] [alt: lipid nanoparticle illustration with podcast symbol overlay] Authors: Sarah Crespi; Elie Dolgin Episode page: https://www.science.org/doi/10.1126/science.adc9455 About the Science Podcast: https://www.science.org/content/page/about-science-podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

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A team effort to save a giant fish, the power of moonlight, and how scientists can navigate a tough political environment

First up on the podcast, along Brazil’s Juruá River, local residents have been working with scientists to manage a giant fish called the arapaima—affecting the land, the people, and the economy. Contr...

7 Touko 53min

Watching a spiders’ heart beat, epigenetic ethics, and what science biographies reveal about fame

First up on the podcast, Online News Editor David Grimm shares a batch of fun stories with podcast host Sarah Crespi—from spider hearts racing when traffic gets loud to a disease-preventing house. Sta...

30 Huhti 46min

Cleaning up uranium mining, and how the heart avoids cancer

First up on the podcast, freelance science and environmental journalist Quentin Septer joins host Sarah Crespi to talk about a controversial uranium mine getting fast-tracked in South Dakota. Septer c...

23 Huhti 30min

The normals | Episode 3

The final of a three-part limited Science Podcast series that looks at the history of normal human subjects in research In episode two, we heard what happened to the normals program after church volu...

21 Huhti 33min

How to keep quantum computers cool, whether prediction markets harm public health, and podcasting on podcasting

First up on the podcast, quantum computers require extremely low temperatures—less than 1°C away from absolute zero. But getting down to those temperatures has usually required dilution fridges using ...

16 Huhti 50min

The Normals | Episode 2

Last time on The Normals, we learned that in the 1950s, the National Institutes of Health (NIH) wanted to recruit many healthy volunteers for basic research. Two peace churches, the Mennonites and the...

14 Huhti 27min

A chimpanzee ‘civil war,’ and NASA plans for nuclear propulsion

First up on the podcast, freelance science journalist Hannah Richter joins host Sarah Crespi to discuss NASA’s plans to send a nuclear-powered spacecraft to Mars in less than 3 years. Having not launc...

9 Huhti 42min

The Normals | Episode 1

How do we know what's normal in a person? In the early 1950s, the National Institutes of Health (NIH) set out to do something unprecedented. It wanted to start studying normal humans on a grand scale....

7 Huhti 23min