Are GLP-1 Drugs "the Greatest Medical Breakthrough of the 21st Century"?

Are GLP-1 Drugs "the Greatest Medical Breakthrough of the 21st Century"?

In the past few years, we've learned that GLP-1 drugs don’t just help with diabetes or increase people’s feelings of fullness to help them lose weight. They have broad effects on substance abuse and behavior. They even seem to help with otherwise incurable illnesses, like Alzheimer's and schizophrenia. This month, a team of scientists studying 2 million patients in the Veterans Affairs medical system found that GLP-1s were associated with “a reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimer’s disease and dementia), coagulation disorders (clotting), cardiometabolic disorders (like strokes and heart attacks), infectious illnesses and several respiratory conditions.” Today’s guest is a coauthor on the paper, Ziyad Al-Aly. He is a physician-scientist at Washington University in St. Louis. We talk about his new paper, the steps he took to make sure his findings were trustworthy, why GLP-1 drugs might work so well, what they’re teaching us about the brain and body, how they’re scrambling our sense of where volition begins and where free will ends, and what scientists should do next with the revelation that these drugs have effects that go far beyond obesity and diabetes. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Ziyad Al-Aly Producer: Devon Baroldi Links: Al-Aly et al. on the effectiveness and risks of GLP-1 drugs [link] Learn more about your ad choices. Visit podcastchoices.com/adchoices

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How to Watch Election Night Without Falling for Conspiracy Theories or False Hope

How to Watch Election Night Without Falling for Conspiracy Theories or False Hope

Today’s guest (our final preelection guest) is David Wasserman, political analyst with the Cook Political Report, who also helps out with the NBC decision desk. There are dozens, maybe hundreds, of pe...

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This Small Pennsylvania Town Explains the 2024 Election

This Small Pennsylvania Town Explains the 2024 Election

Today, a close look at the history of a Pennsylvania town and how that history contains within it the story of the 2024 election. In September, Donald Trump claimed that the city of Charleroi, Pennsyl...

1 Marras 202454min

Why Is Every Recent Presidential Election So Close?

Why Is Every Recent Presidential Election So Close?

My favorite sort of social phenomenon is something that seems normal to modern eyes that is actually incredibly unusual. We take it for granted that every presidential election is a nail-biter these d...

25 Loka 202447min

Is Radical Human Life Extension Possible?

Is Radical Human Life Extension Possible?

In 1900, the average US life expectancy was 47 years old. That's the current age of Tom Brady, Ryan Reynolds, and Shakira. But extraordinary advances in medicine and public health have surged lifespan...

18 Loka 202453min

America's Young Men Are Falling Behind—and Shifting Right

America's Young Men Are Falling Behind—and Shifting Right

Today: the state of men and what's really happening in the gender divide in politics. Many young men are falling behind economically and socially at the same time that men and women are coming apart p...

11 Loka 202448min

Is the Middle East on the Verge of All-Out War?

Is the Middle East on the Verge of All-Out War?

Since October 7, 2023, many have feared that the conflict between Israel and Hamas would bloom into a wider war that would consume the Middle East. Today, we are dangerously close to that reality. In ...

4 Loka 20241h 2min

The Surprising Science of Cynicism (Plus: The Policy Paradox of the 2024 Election)

The Surprising Science of Cynicism (Plus: The Policy Paradox of the 2024 Election)

Derek shares his biggest frustrations about the 2024 election, like the lack of a policy debate and blind spots in news coverage and polling analysis. Then he welcomes Jamil Zaki to the show: a profes...

27 Syys 20241h 5min

A Sports Mystery: What Happened to the NFL Quarterback?

A Sports Mystery: What Happened to the NFL Quarterback?

Today, a mystery about what some people consider the most important position in sports: What the hell is going on with the NFL quarterback? We are two weeks into the 2024 football season. And as sever...

20 Syys 202445min

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