Are GLP-1 Drugs "the Greatest Medical Breakthrough of the 21st Century"?

Are GLP-1 Drugs "the Greatest Medical Breakthrough of the 21st Century"?

In the past few years, we've learned that GLP-1 drugs don’t just help with diabetes or increase people’s feelings of fullness to help them lose weight. They have broad effects on substance abuse and behavior. They even seem to help with otherwise incurable illnesses, like Alzheimer's and schizophrenia. This month, a team of scientists studying 2 million patients in the Veterans Affairs medical system found that GLP-1s were associated with “a reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimer’s disease and dementia), coagulation disorders (clotting), cardiometabolic disorders (like strokes and heart attacks), infectious illnesses and several respiratory conditions.” Today’s guest is a coauthor on the paper, Ziyad Al-Aly. He is a physician-scientist at Washington University in St. Louis. We talk about his new paper, the steps he took to make sure his findings were trustworthy, why GLP-1 drugs might work so well, what they’re teaching us about the brain and body, how they’re scrambling our sense of where volition begins and where free will ends, and what scientists should do next with the revelation that these drugs have effects that go far beyond obesity and diabetes. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Ziyad Al-Aly Producer: Devon Baroldi Links: Al-Aly et al. on the effectiveness and risks of GLP-1 drugs [link] Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Oppenheimer: The Genius, the Film, and the Project That Changed the World

Oppenheimer: The Genius, the Film, and the Project That Changed the World

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How Hollywood Drove Its Business Model Off a Cliff

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Americans Think the Economy Is Terrible. The Data Tell Another Story.

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What Just Happened in Russia This Weekend?

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Why Fertility Rates Are Plunging—in the U.S., South Korea, and Everywhere Else

Why Fertility Rates Are Plunging—in the U.S., South Korea, and Everywhere Else

Last year, there were 3,661,220 babies born in the U.S. That sounds like a lot. But historically speaking, it’s really not. It’s actually 15 percent below our peak in 2007. And it means America’s tota...

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Why So Many Young Men Are Lonely, Sexless, and Extremely Online

Why So Many Young Men Are Lonely, Sexless, and Extremely Online

Today’s episode is about the state of men in America. Last week, the non-profit institute Equimondo published a report on the state of men and boys in America: “Many men—especially younger men—are soc...

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