Are GLP-1 Drugs "the Greatest Medical Breakthrough of the 21st Century"?

Are GLP-1 Drugs "the Greatest Medical Breakthrough of the 21st Century"?

In the past few years, we've learned that GLP-1 drugs don’t just help with diabetes or increase people’s feelings of fullness to help them lose weight. They have broad effects on substance abuse and behavior. They even seem to help with otherwise incurable illnesses, like Alzheimer's and schizophrenia. This month, a team of scientists studying 2 million patients in the Veterans Affairs medical system found that GLP-1s were associated with “a reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimer’s disease and dementia), coagulation disorders (clotting), cardiometabolic disorders (like strokes and heart attacks), infectious illnesses and several respiratory conditions.” Today’s guest is a coauthor on the paper, Ziyad Al-Aly. He is a physician-scientist at Washington University in St. Louis. We talk about his new paper, the steps he took to make sure his findings were trustworthy, why GLP-1 drugs might work so well, what they’re teaching us about the brain and body, how they’re scrambling our sense of where volition begins and where free will ends, and what scientists should do next with the revelation that these drugs have effects that go far beyond obesity and diabetes. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Ziyad Al-Aly Producer: Devon Baroldi Links: Al-Aly et al. on the effectiveness and risks of GLP-1 drugs [link] Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Silicon Valley Bank Collapse FAQ: Whose Fault Is It? How Can We Stop a Bank Panic? What Comes Next?

Silicon Valley Bank Collapse FAQ: Whose Fault Is It? How Can We Stop a Bank Panic? What Comes Next?

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Under President Biden, the U.S. is pivoting toward what some people call “industrial policy”—that is, using the government to support key industries, like green energy manufacturing and the manufactur...

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How the Media Failed Its COVID Test: The Truth Behind the Lab Leak and Masking Debates

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Today’s episode is a long one: It’s about the debate over media coverage of COVID. Three years after the fateful March of 2020, when it feels like the world shut down for COVID, we are revisiting two ...

7 Maalis 20231h 34min

Why Are American Teens So Unhappy? How Do We Solve This Crisis?

Why Are American Teens So Unhappy? How Do We Solve This Crisis?

This is our second installment of happiness week on the Plain English podcast. On Tuesday, I spoke with the directors of the Harvard Study of Adult Development about what makes a good life, based on t...

3 Maalis 202355min

Happiness in America, Part 1: The Secret to a 'Good Life,' According to an 80-Year Study

Happiness in America, Part 1: The Secret to a 'Good Life,' According to an 80-Year Study

Americans have never had more access to social technology. It’s easier to talk to friends and family members hundreds of miles away; easier to see their faces; and easier to find single people to date...

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The Science of How Music Hits Have Changed in the Last 60 Years

The Science of How Music Hits Have Changed in the Last 60 Years

How does technology shape art? Why has songwriting become more of a visual skill in the 21st century? Why are today's hit songs shorter than songs from any period since the Beatles? What happened to t...

24 Helmi 202352min

Bing Chatbot Gone Wild and Why AI Could Be the Story of the Decade

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Large language models like ChatGPT and Bing’s chatbot can tell stories. They can analyze the effects of agricultural AI on American and Chinese farms. They can pass medical licensing exams, summarize ...

21 Helmi 202351min

UFOs and Aliens and Drones and Balloons: Understanding the U.S. Sky Wars

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Since a big white Chinese spy balloon floated across the ocean and into U.S. airspace, the United States has shot down four objects over North American skies. What are we looking at, and what are we s...

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