Are GLP-1 Drugs "the Greatest Medical Breakthrough of the 21st Century"?

Are GLP-1 Drugs "the Greatest Medical Breakthrough of the 21st Century"?

In the past few years, we've learned that GLP-1 drugs don’t just help with diabetes or increase people’s feelings of fullness to help them lose weight. They have broad effects on substance abuse and behavior. They even seem to help with otherwise incurable illnesses, like Alzheimer's and schizophrenia. This month, a team of scientists studying 2 million patients in the Veterans Affairs medical system found that GLP-1s were associated with “a reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimer’s disease and dementia), coagulation disorders (clotting), cardiometabolic disorders (like strokes and heart attacks), infectious illnesses and several respiratory conditions.” Today’s guest is a coauthor on the paper, Ziyad Al-Aly. He is a physician-scientist at Washington University in St. Louis. We talk about his new paper, the steps he took to make sure his findings were trustworthy, why GLP-1 drugs might work so well, what they’re teaching us about the brain and body, how they’re scrambling our sense of where volition begins and where free will ends, and what scientists should do next with the revelation that these drugs have effects that go far beyond obesity and diabetes. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Ziyad Al-Aly Producer: Devon Baroldi Links: Al-Aly et al. on the effectiveness and risks of GLP-1 drugs [link] Learn more about your ad choices. Visit podcastchoices.com/adchoices

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California’s Elections Sent an Important Message. What Is It?

California’s Elections Sent an Important Message. What Is It?

Today’s episode is about two California elections and the message they sent to the rest of the country. In San Francisco, progressive district attorney Chesa Boudin was recalled by voters after years ...

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Curiosity Corner: America’s Gun Dilemma, the Future of Corporate Politics, Relationship Advice, and More!

Curiosity Corner: America’s Gun Dilemma, the Future of Corporate Politics, Relationship Advice, and More!

Welcome to Curiosity Corner! In our first ever all-mailbag episode, Derek answers a Republican’s question about gun control, explains how American companies became so political, revisits a controversi...

7 Kesä 202235min

America’s Gun Problem Is Impossible

America’s Gun Problem Is Impossible

The Texas school shooting is part of a grisly ritual in American life. A tragedy, followed by mourning, followed by inaction, followed by several months, followed by another tragedy. What can be done?...

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What's Going on With the U.S. Housing Market?

What's Going on With the U.S. Housing Market?

It's our first Curiosity Corner podcast! We asked you to tell us what questions you wanted us to answer, and a lot of you had the same thought on your mind: housing. In this podcast, we answer: What's...

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Why Does the Internet Hate Amber Heard?

Why Does the Internet Hate Amber Heard?

It's the trial of the century—kind of. The legal showdown between Johnny Depp and Amber Heard has captivated the country, and Derek is a bit confused. Why is everybody talking about this miserable cel...

20 Touko 202240min

The Mystery of America's Missing Baby Formula

The Mystery of America's Missing Baby Formula

America's infant formula shortage is very strange and very embarrassing. Nationwide, more than 40 percent of formula is out of stock, and in many states, like Texas and Tennessee, more than half of it...

18 Touko 202244min

Why the U.S. Could Be Headed For the "Weirdest Recession Ever"

Why the U.S. Could Be Headed For the "Weirdest Recession Ever"

Crypto crashes, rate hikes, recession, fears, and inflation prints: The U.S. economy is in a very bizarre place right now, and Derek needs help explaining it. Michael Batnick and Ben Carlson of Rithol...

17 Touko 202252min

Market Meltdown: Why Tech and Crypto Are Crashing - and What Happens Next

Market Meltdown: Why Tech and Crypto Are Crashing - and What Happens Next

The stock market is absolutely gross right now. Everything is down, except (as loyal listeners know) the CATAN portfolio. Crypto has cratered, growth stocks have been ravaged, and hedge funds are impl...

11 Touko 202252min

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