Humanity’s Awesome, Terrifying Takeover of Evolution

Humanity’s Awesome, Terrifying Takeover of Evolution

For years now, I’ve had the same recurring worry: Am I focusing on the trivial? When future generations look back on this moment in history, will they remember the daily political fights — or will everything just look like a sideshow compared to humans being able to edit genetic code?

The technology I’m referring to, known as CRISPR, could cure genetic diseases like sickle-cell anemia and Huntington’s. It could let us regulate height, hair color, and vulnerabilities in our children. And, one day, it has the potential to imbue human beings with superhuman characteristics — making us stronger, faster, smarter. Nor is it just us. CRISPR lets us edit other animals and plants, with all kinds of beckoning possibilities, some wonderful, some terrible. We cannot do all this yet. But it’s coming, and soon.

Walter Isaacson is the former editor of Time magazine, the former head of CNN, and author of biographies of everyone from Albert Einstein to Benjamin Franklin to Steve Jobs. However, his newest book, “The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race” is much more than a biography of Jennifer Doudna, a Nobel Prize winning scientist who was essential to developing CRISPR. It’s a biography of the scientific process that led to CRISPR, and the people trying to understand its moral, political and human implications.

In this conversation, I get to ask Isaacson the questions I’ve wanted to focus on myself: Is it wrong to edit your kid’s genes? Is it cruel not to? What happens when CRISPR and capitalism collide? Will we witness the rise of a superhuman genetic elite? And what kind of political and economic systems do we need to start building to ensure this technology is used in just ways?

Recommendations:

"The Bully Pulpit" by Doris Kearns Goodwin

"The Moviegoer" by Walker Percy

"The Eighth Day of Creation" by Horace Freeland Judson

"Winnie the Pooh" by A.A. Milne

You can find transcripts (posted midday) and more episodes of "The Ezra Klein Show" at nytimes.com/ezra-klein-podcast, and you can find Ezra on Twitter @ezraklein.

Thoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.

“The Ezra Klein Show” is produced by Rogé Karma and Jeff Geld; fact-checking by Michelle Harris; original music by Isaac Jones; mixing by Jeff Geld.

Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

Jaksot(458)

Best Of: Tired? Distracted? Burned Out? Listen to This.

Best Of: Tired? Distracted? Burned Out? Listen to This.

I’m convinced that attention is the most important human faculty. Your life, after all, is just the sum total of the things you’ve paid attention to. We lament our attention issues all the time — how distracted we are, how drained we feel, how hard it is to stay focused or present. And yet, while there’s no shortage of advice on how to improve our sleep hygiene or spending habits or physical fitness, there’s hardly any good information about how to build and replenish our capacity for paying attention.Gloria Mark is a professor at the University of California, Irvine, and the author of the book “Attention Span.” And she’s one of the few people who have deeply studied the way our attention works, how that’s been changing and what we can do to stop frittering away our attention budgets. This was our first release of 2024, a kind of New Year’s resolutions episode. And since it can sometimes help to be reminded of the intentions with which you began your year — especially in the midst of a high-intensity election season — we thought we’d share it again. Book recommendations:“The Challenger Launch Decision” by Diane Vaughan“The Undoing Project” by Michael Lewis“The God Equation” by Michio KakuThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast, and you can find Ezra on Twitter @ezraklein. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.This episode of “The Ezra Klein Show” was produced by Claire Gordon. Fact-checking by Michelle Harris, Mary Marge Locker and Kate Sinclair. Our senior engineer is Jeff Geld. Our senior editor is Claire Gordon. The show’s production team also includes Rollin Hu and Kristin Lin. Original music by Isaac Jones. Audience strategy by Kristina Samulewski and Shannon Busta. The executive producer of New York Times Opinion Audio is Annie-Rose Strasser. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

30 Elo 202457min

Best Of: The Men — and Boys — Are Not Alright

Best Of: The Men — and Boys — Are Not Alright

We recently did an episode on the strange new gender politics that have emerged in the 2024 election. But we only briefly touched on the social and economic changes that underlie this new politics — the very real ways boys and men have been falling behind.In March 2023, though, we dedicated a whole episode to that subject. Our guest was Richard Reeves, the author of the 2022 book “Of Boys and Men: Why the Modern Male Is Struggling, Why It Matters, and What to Do About It,” who recently founded the American Institute for Boys and Men to develop solutions for the gender gap he describes in his research. He argues that you can’t understand inequality in America today without understanding the specific challenges facing men and boys. And I would add that there’s no way to fully understand the politics of this election without understanding that, either. So we’re rerunning this episode, because Reeves’s insights on this feel more relevant than ever.We discuss how the current education system places boys at a disadvantage, why boys raised in poverty are less likely than girls to escape it, why so many young men look to figures like Jordan Peterson and Andrew Tate for inspiration, what a better social script for masculinity might look like and more.Mentioned:"Gender Achievement Gaps in U.S. School Districts" by Sean F. Reardon, Erin M. Fahle, Demetra Kalogrides, Anne Podolsky and Rosalia C. Zarate"Redshirt the Boys" by Richard ReevesBook recommendations:"The Tenuous Attachments of Working-Class Men" by Kathryn Edin, Timothy Nelson, Andrew Cherlin and Robert FrancisCareer and Family by Claudia GoldinThe Life of Dad by Anna MachinThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast, and you can find Ezra on Twitter @ezraklein. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.This episode of “The Ezra Klein Show” was produced by Emefa Agawu, Annie Galvin, Jeff Geld, Rogé Karma and Kristin Lin. Fact-checking by Michelle Harris, Mary Marge Locker and Kate Sinclair. Mixing by Sonia Herrero. Original music by Isaac Jones. Audience strategy by Shannon Busta. The executive producer of New York Times Opinion Audio is Annie-Rose Strasser. Special thanks to Carol Sabouraud and Kristina Samulewski. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

27 Elo 20241h 58min

Kamala Harris Wants to Win

Kamala Harris Wants to Win

On Thursday night, Kamala Harris reintroduced herself to America. And by the standards of Democratic convention speeches, this one was pretty unusual. In this conversation I’m joined by my editor, Aaron Retica, to discuss what Harris’s speech reveals about the candidate, the campaign she’s going to run and how she believes she can win in November.Mentioned:The Truths We Hold by Kamala HarrisThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.This episode of “The Ezra Klein Show” was produced by Claire Gordon. Fact-checking by Michelle Harris, with Jack McCordick. Our senior engineer is Jeff Geld, with additional mixing by Aman Sahota. Our senior editor is Claire Gordon. The show’s production team also includes Annie Galvin, Rollin Hu, Elias Isquith and Kristin Lin. Original music by Isaac Jones. Audience strategy by Kristina Samulewski and Shannon Busta. The executive producer of New York Times Opinion Audio is Annie-Rose Strasser. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

23 Elo 202443min

Can the Democratic Party Reclaim Freedom?

Can the Democratic Party Reclaim Freedom?

Democrats spent the third night of their convention pitching themselves as the party of freedom. In this conversation, my producer Annie Galvin joined me on the show to take a deep look at that messaging. Why do Democrats see an opportunity in this election to seize an idea that Republicans have monopolized for decades? What’s the meaning of “freedom” that Democrats seem to be embracing? And how does this message square with other Democratic Party values, like belief in the ability of government to do good?Mentioned:How Democracies Die by Steven Levitsky and Daniel ZiblattThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.This episode of “The Ezra Klein Show” was produced and hosted by Annie Galvin. Fact-checking by Michelle Harris, with Kate Sinclair and Mary Marge Locker. Our senior engineer is Jeff Geld, with additional mixing by Aman Sahota. Our senior editor is Claire Gordon. The show’s production team also includes Rollin Hu, Elias Isquith and Kristin Lin. Original music by Isaac Jones. Audience strategy by Kristina Samulewski and Shannon Busta. The executive producer of New York Times Opinion Audio is Annie-Rose Strasser. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

22 Elo 202443min

The Obamas Strike Back

The Obamas Strike Back

Is Obamaism making a comeback? Tuesday night at the Democratic National Convention, Michelle and Barack Obama electrified the crowd with the most powerful speeches of the week so far, and seemed to anoint Kamala Harris as the inheritor of their political movement. For this audio diary, I’m joined by my producer Elias Isquith to dissect those two speeches. We discuss what Obamaism was in 2008 and 2012, and what it means to pass the baton to Harris in 2024.Mentioned:“Biden Made Trump Bigger. Harris Makes Him Smaller.” by Ezra Klein“That Feeling You Recognize? Obamacore.” by Nate JonesThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.This episode of “The Ezra Klein Show” was produced and hosted by Elias Isquith. Fact-checking by Michelle Harris, with Mary Marge Locker and Kate Sinclair. Our senior engineer is Jeff Geld. Our senior editor is Claire Gordon. The show’s production team also includes Annie Galvin, Rollin Hu, Kristin Lin and Aman Sahota. Original music by Aman Sahota and Isaac Jones. Audience strategy by Kristina Samulewski and Shannon Busta. The executive producer of New York Times Opinion Audio is Annie-Rose Strasser. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

21 Elo 202439min

Democrats Don’t Think They Have This Election Won

Democrats Don’t Think They Have This Election Won

I’m reporting from the Democratic National Convention this week, so we’re going to try something a little different on the show — a daily audio report of what I’m seeing and hearing here in Chicago. For our first installment, I’m joined by my producer, Rollin Hu, to discuss what the convention’s opening night revealed about the Democratic Party after a tumultuous couple of months. We talk about how Joe Biden transformed the party over the past four years, the behind-the-scenes efforts to shape the party under Kamala Harris, the impact of the Gaza protests and why many Democrats — despite Harris’s recent momentum — feel cautious about their odds in November.Mentioned:“Trump Turned the Democratic Party Into a Pitiless Machine” by Ezra KleinRep. Alexandria Ocasio-Cortez’s Full Speech at Democratic National ConventionThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.This episode of “The Ezra Klein Show” was produced and hosted by Rollin Hu. Fact-checking by Michelle Harris, with Kate Sinclair and Mary Marge Locker. Our senior engineer is Jeff Geld, with additional mixing by Aman Sahota. Our senior editor is Claire Gordon. The show’s production team also includes Annie Galvin, Elias Isquith and Kristin Lin. Original music by Isaac Jones. Audience strategy by Kristina Samulewski and Shannon Busta. The executive producer of New York Times Opinion Audio is Annie-Rose Strasser. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

20 Elo 202432min

Manliness, Cat Ladies, Fertility Panic and the 2024 Election

Manliness, Cat Ladies, Fertility Panic and the 2024 Election

A strange new gender politics is roiling the 2024 election. At the Republican National Convention, Donald Trump made his nomination a show of campy masculinity, with Hulk Hogan, Kid Rock and Dana White, the president of the Ultimate Fighting Championship, warming up the crowd. JD Vance’s first viral moments have been comments he made in 2021 about “childless cat ladies” running the Democratic Party and a “thought experiment” assigning extra votes to parents because they have more of an “investment in the future of this country.” Meanwhile, Kamala Harris is centering her campaign on abortion rights, and Tim Walz has been playing up his own classically masculine profile — as a former football coach, hunter and Midwestern dad.  What are the two sides here really saying about gender and family? And what are the new fault lines of our modern-day gender wars?Christine Emba is a staff writer at The Atlantic and the author of “Rethinking Sex: A Provocation.” Zack Beauchamp is a senior correspondent at Vox and the author of the new book “The Reactionary Spirit: How America's Most Insidious Political Tradition Swept the World.” In this conversation, we discuss some influences on JD Vance’s ideas about gender and family, the tensions between those ideas and the beliefs about gender represented by Donald Trump, the competing visions of masculinity presented by the two parties in this election, how Dobbs changed Democrats’ message on gender and family, and more.Mentioned:“What Does the 'Post-Liberal Right' Actually Want?” with Patrick Deneen on The Ezra Klein Show“A Powerful Theory of Why the Far Right Is Thriving Across the Globe” with Pippa Norris on The Ezra Klein ShowBook Recommendations:Black Pill by Elle ReeveWhat Are Children For? by Anastasia Berg and Rachel WisemanThe Lord of the Rings trilogy by J.R.R. TolkienJustice, Gender, and the Family by Susan Moller OkinCultural Backlash by Pippa Norris, Ronald InglehartConservative Parties and the Birth of Democracy by Daniel ZiblattThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.This episode of “The Ezra Klein Show” was produced by Annie Galvin. Fact-checking by Michelle Harris, with Mary Marge Locker. Our senior engineer is Jeff Geld, with additional mixing by Isaac Jones and Aman Sahota. Our senior editor is Claire Gordon. The show’s production team also includes Rollin Hu, Elias Isquith and Kristin Lin. Original music by Isaac Jones. Audience strategy by Kristina Samulewski and Shannon Busta. The executive producer of New York Times Opinion Audio is Annie-Rose Strasser. Special thanks to Sonia Herrero. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

16 Elo 20241h 30min

Nate Silver on Kamala Harris’s Chances and the Mistakes of the ‘Indigo Blob’

Nate Silver on Kamala Harris’s Chances and the Mistakes of the ‘Indigo Blob’

Risk has been on my mind this year. For Democrats, the question of whether Joe Biden should drop out was really a question about risk – the risk of keeping him on the ticket versus the risk of the unknown. And it’s hard to think through those kinds of questions when you have incomplete information and so much you can’t predict. After all, few election models forecast that Kamala Harris would have the kind of momentum we’ve seen the last few weeks.Nate Silver’s new book, “On the Edge: The Art of Risking Everything,” is all about thinking through risk, and the people who do it professionally, from gamblers to venture capitalists. (Silver is a poker player himself.) And so I wanted to talk to him about how that kind of thinking could help in our politics – and its limits.We discuss how Harris is performing in Silver’s election model; what he means when he talks about “the village” and “the river”; what Silver observed profiling Peter Thiel and Sam Bankman-Fried, two notorious risk-takers, for the book; the trade-offs of Harris’s decision to choose Tim Walz over Josh Shapiro as a running mate; and more.This episode contains strong language.Mentioned:The Contrarian by Max Chafkin“Nancy Pelosi on Joe Biden, Tim Walz and Donald Trump” by The Ezra Klein ShowBook Recommendations:The Hour Between Dog and Wolf by John CoatesThe Making of the Atomic Bomb by Richard RhodesAddiction by Design by Natasha Dow SchüllThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.This episode of “The Ezra Klein Show” was produced by Rollin Hu. Fact-checking by Kate Sinclair and Mary Marge Locker. Our senior engineer is Jeff Geld, with additional mixing by Efim Shapiro and Aman Sahota. Our senior editor is Claire Gordon. The show’s production team also includes Annie Galvin, Michelle Harris, Elias Isquith and Kristin Lin. Original music by Isaac Jones. Audience strategy by Kristina Samulewski and Shannon Busta. The executive producer of New York Times Opinion Audio is Annie-Rose Strasser. Special thanks to Sonia Herrero. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

13 Elo 20241h 6min

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