Science of Muscle Growth, Increasing Strength & Muscular Recovery
In this episode, I describe how our brain and nervous system control muscle tissue and how to leverage that for muscle maintenance, growth (hypertrophy) and recovery. I explain how neurons control muscle contractions and limb movements. I explain muscle metabolism and muscle fiber recruitment. I detail protocols for increasing muscular growth and for neuro-muscular recovery. I explain the effects of deliberate cold, anti-inflammatory agents, and anti-histamines on training progress. I describe science-supported protocols using certain weight load ranges, total sets per week, training intensity, frequency, and in-between set activities if one's goal is to increase muscle growth, strength or endurance. I review three foundational compounds and nutrients and three optimization compounds and nutrients that have been shown to improve neuro-muscular performance. Finally, I explain how to leverage exercise and weight training to enhance cognitive function. Read the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://www.wakingup.com/huberman Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
31 Touko 20212h
How to Lose Fat With Science-Based Tools
This episode I describe the science of fat loss, including how fat is mobilized and oxidized (burned) and how to increase fat burning by leveraging the nervous system. Most people don't realize it, but our neurons connect to our fat and release epinephrine/adrenaline to facilitate fat oxidation. Read the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://www.wakingup.com/huberman Timestamps 00:00:00 Introduction 00:00:31 Sponsors: AG1, LMNT & Waking Up 00:06:00 Fat Loss: The Key Role of Neurons 00:08:44 The First Law of Fat Loss 00:11:00 Neurons Connect To Fat! (& That Really Matters) 00:13:38 5 Pillars of Metabolism: Sleep, Essential Fatty Acids, Glutamine, Microbiome, Thyroid 00:19:20 Mindset Truly Matters: Amazing Examples of Beliefs on Fat Loss 00:23:08 Our Brain Talks To Our Fat 00:25:00 The Most Incredible & Dangerous Fat Loss Agent 00:27:28 Losing Fat Is a Two-Part Process: Mobilization and Oxidation 00:32:25 The Critical Role of Adrenaline/Epinephrine, But NOT from Adrenal Glands 00:34:45 Fidgeting & Shivering: A Powerful Science-Supported Method For Fat Loss 00:41:24 How Fidgeting Works: Promotes Epinephrine Release into Fat. “N-E-A-T” 00:44:55 Two Ways of Using Shivering To Accelerate Fat Loss 00:47:30 White, Brown & Beige Fat; & Using Cold-Induced Shiver To Burn Fat 00:50:25 How To Use Cold Properly To Stimulate Fat Loss: Succinate Release Is Key/Shiver 00:52:26 Exact Protocols: (1-5X per week); Don’t Adapt! Submerge and Exit “Sets & Reps” 00:56:15 thecoldplunge.com see “protocols” tab Cold-Shiver-Fat-Loss Tool (cost free) 00:58:03 If Fat-Loss Is Your Goal, Avoid Cold Adaptation: Remember Polar Bear Swimmers 00:58:17 Irisin: Underwhelming; Succinate Is The Real Deal 01:00:00 Brown Fat, Why Babies Can’t Shiver and Becoming a Hotter Furnace, Adding Heat 01:01:55 Ice On Back of The Neck, Cold Underpants: Not A Great Idea For Fat Loss 01:04:00 A Key Paper For the Aficionados: www.ncbi.nlm.nih.gov/pmc/articles/PMC2826518/ 01:05:00 Spot Reduction: There May Be Hope After All. Targeting Specific Fat Pads. 01:09:20 Exercising For Fat Loss: What Is Best? High Intensity, Sprinting, Moderate Intensity? 01:13:30 Exercising Fasted: Does It Truly Accelerate Fat Loss/Oxidation. 01:16:30 The 90 Minute Rule: After 90 Minutes, The Fasted Exercisers Start To Burn More Fat 01:18:15 If High-Intensity Training Is Done First, The Benefits of Fasting Arrive Before 90min. 01:22:44 Post-Exercise Metabolic Increases: How To Bias This Toward Fat Oxidation 01:26:05 A Protocol For Exercise-Induced Fat Loss; Adrenalin Is The Effector 01:28:50 Supplements/Compounds For Fat Loss Part: Caffeine Fidgeting, & Caffeine Adaptation 01:34:30 Ephedrine, Fenfluramine: Removed From Market Due to Safety Concerns 01:35:22 GLP1 (Glucagon-Like Peptide 1), Yerba Mate, Guayusa Tea, Semaglutide 01:40:30 Berberine, Metformin: Glucose/Insulin Reduction, Increase Fat Oxidation: But Caution 01:41:28 Gardner Lab Results: What You Eat May Not Matter, But Adherence Is Key Tool 01:43:00 examine.com & Enter “Yerba Mate”: Lowers Heart Rate Even Though Is a Stimulant 01:44:35 Acetyl-L-Carnitine: Facilitates Fat Oxidation 01:48:00 Summary List of Tools & How Nervous System Controls Fat Loss 01:51:20 Cost Free & Other Ways To Support Our Podcast, Making Sure We See Feedback Disclaimer Learn more about your ad choices. Visit megaphone.fm/adchoices
24 Touko 20211h 49min
How to Learn Skills Faster
This episode I discuss the science and practice of learning physical skills: what it involves at a biological level, and what to focus on during skill learning at each stage to maximize learning speed and depth. I also describe what to do immediately after a training session (note: this is different than the optimal protocol for cognitive skill training) and as you progress to more advanced levels of performance. I also cover the science of skill-based visualization which does have benefits, but only if done correctly and at the correct times. I discuss auto-replay of skill learning in the brain during sleep and the value of adding in post-training ‘deliberately idle’ sessions. I cover how to immediately improve limb-range-of-motion by leveraging cerebellum function, error generation, optimal repetition numbers for learning and more. As always, scientific mechanism, peer-reviewed studies and science-based protocols are discussed. Read the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1 : https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://www.wakingup.com/huberman Timestamps 00:00:00 Introduction 00:00:31 Sponsors: AG1, LMNT & Waking Up 00:06:28 Skill Acquisition: Mental & Physical 00:08:40 Clarification About Cold, Heat & Caffeine 00:12:45 Tool: How To Quickly Eliminate the Side-Stitch ‘Cramp’ & Boost HRV Entrainment 00:16:08 Physical Skills: Open-Loop Versus Closed-Loop 00:18:50 Three Key Components To Any Skill 00:21:00 Sources of Control for Movement: 1) CPGs Govern Rhythmic Learned Behavior 00:23:30 Upper Motor Neurons for Deliberate Movement & Learning 00:25:00 Lower Motor Neurons Control Action Execution 00:25:26 What To Focus On While Learning 00:27:10 The Reality of Skill Learning & the 10,000 Hours Myth 00:28:30 Repetitions & The Super Mario Effect: Error Signals vs. Error Signals + Punishment 00:34:00 Learning To Win, Every Time 00:39:26 Errors Solve the Problem of What To Focus On While Trying to Learn Skills 00:43:00 Why Increasing Baseline Levels of Dopamine Prior To Learning Is Bad 00:44:40 The Framing Effect (& Protocol Defined) 00:46:10 A Note & Warning To Coaches 00:48:30 What To Do Immediately After Your Physical Skill Learning Practice 00:53:48 Leveraging Uncertainty 00:56:59 What to Pay Attention To While Striving To Improve 01:04:45 Protocol Synthesis Part One 01:07:10 Super-Slow-Motion Learning Training: Only Useful After Some Proficiency Is Attained 01:11:06 How To Move From Intermediate To Advanced Skill Execution Faster: Metronomes 01:16:44 Increasing Speed Even If It Means More Errors: Training Central Pattern Generators 01:19:12 Integrated Learning: Leveraging Your Cerebellum (“Mini-Brain”) 01:22:02 Protocol For Increasing Limb Range of Motion, Immediately 01:28:30 Visualization/Mental Rehearsal: How To Do It Correctly 01:33:50 Results From 15 Minutes Per Day, 5 Days Per Week Visualization (vs. Actual Training) 01:35:34 Imagining Something Is Very Different Than Actually Experiencing It 01:37:58 Cadence Training & Learning “Carryover” 01:39:00 Ingestible Compounds That Support Skill Learning: Motivation, Repetitions, Alpha-GPC 01:43:39 Summary & Sequencing Tools: Reps, Fails, Idle Time, Sleep, Metronome, Visualization 01:46:20 Density Training: Comparing Ultradian- & Non-Ultradian Training Sessions 01:49:24 Cost-Free Ways to Support Us, Sponsors & Alternate Channels, Closing Remarks Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
17 Touko 20211h 47min
Supercharge Exercise Performance & Recovery with Cooling
This episode I explain the science of heating and cooling the body, a process called thermoregulation-- and how to apply that knowledge to significantly improve physical performance. I describe the three areas of our body that can remove heat (or bring heat into the body) faster than anywhere else, why that is so, and how proper cooling of these areas with specific protocols can allow people to perform 200-600% more volume and repetitions of resistance exercises at the same weight loads, or to run, cycle or swim significantly further. I also describe how to use directed cooling of so-called glabrous skin: the bottoms of feet, palms and face, to significantly enhance recovery times from exercise. Also, why the common practices of trying to heat up or cool the body via the torso or whole-body submersion in cold can be inefficient and/or dangerous-- and the better alternatives. Finally, I discuss the temperature-effects of caffeine, alcohol and anti-inflammatory compounds. The information in this episode is focused on mechanisms and tools for increasing athletic or exercise performance. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Introduction (00:00:31) Sponsors: AG1, LMNT (00:05:08) Physical Performance & Skill Learning (00:06:40) Optimal Learning Protocol (Recap): 4 Steps (00:08:31) Variables Impacting Physical Performance (00:10:00) Temperature Is the Dominant Variable (00:12:08) Understanding Mechanism Is Key (00:13:42) Heat: The Enemy of All Performance (& Why) (00:16:30) Blood Flow & Sweating & Piloerection (00:22:35) Heat Is What Limits Effort: Even If You Feel Fine/Motivated (00:25:29) Proper Cooling Can Double, Triple, Quadruple (Or More) Your Ability (00:26:42) Heat Induced Confusion & Death (00:30:02) The Three Body Parts Best For Heating & Cooling Your Whole Body (00:31:38) Face, Palms, Bottoms of Feet; Glabrous Skin (00:33:00) Arterio-Venous Anastamoses (AVAs) Are Super Cool(ing)! (00:37:15) Palmar Cooling Can Supercharge Your Athletic Performance (00:38:35) ATP, Pyruvate Kinase & Heat (00:40:55) Palmer Cooling Outperforms Anabolic Steroids Several-Fold (00:43:45) Increasing Endurance, Willpower & Persistence (00:46:33) Cardiac Drift, & Moving the ”I Quit” Point (00:50:44) Deliberate Heating: Myths and Better Protocols (00:53:20) Protocols For Self-Directed Cooling To Vastly Improve Performance (00:59:23) How To Use Cold To Recover Faster & More Thoroughly (01:02:05) Ice Baths & Cold Showers Can Prevent Training Progress: mTOR, etc. (01:06:29) Alcohol, Caffeine, NSAIDs: Their Temperature Effects Matter (01:09:44) Are Stimulants Counter Productive For Performance? It Depends. (01:12:00) The Caffeine Rule & “Caffeine Adaptation” (01:14:20) NSAIDs for Training: Performance Enhancements & Risks (01:17:00) The Best Way to Explore Your Own “Parameter Space” (01:18:35) Tools: How To Try (01:21:35) Cost-Free Support, & Additional Support & Resources Title Card Photo Credit: Mike Blabac Disclaimer Learn more about your ad choices. Visit megaphone.fm/adchoices
10 Touko 20211h 20min
Boost Your Energy & Immune System with Cortisol & Adrenaline
This episode I describe the biology of two essential hormones we all make: cortisol and adrenaline (also called epinephrine). Cortisol and adrenaline powerfully regulate our levels of energy, focus and immune system function. I describe various science-supported tools and practices to increase or decrease cortisol and/or adrenaline, depending on one's specific needs and goals. I also describe the biology of nootropics, and how cortisol and adrenaline can improve or degrade learning. Finally, I review the scientific data and tools for timing the release of these hormones to improve memory, energy and immune system function. Read the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://www.wakingup.com/huberman Timestamps 00:00:00 Introduction 00:00:31 Sponsors: AG1, LMNT & Waking Up 00:05:41 Energy & Your Immune System, & Learning Faster 00:08:34 Why & How Intermittent Fasting Increases Growth Hormone 00:11:56 Why Your Stomach Growls 00:13:09 Hot Baths & Hormones 00:14:35 Energy, Adrenaline (Epinephrine), & Cortisol 00:15:48 Cortisol & Cholesterol, Competition With Testosterone & Estrogen 00:17:54 Adrenaline (Epinephrine) Is Your (Immune System’s) Best Friend 00:18:48 Cortisol Basics In Two (Actually 1) Minute/s 00:19:48 Adrenaline Basics In Two Minutes 00:21:32 Tool: Time Your Cortisol Peak To Waking Using Specific Light Intensities 00:27:20 Brief Increases In Cortisol & Adrenaline Boost Energy, Focus & Immunity 00:30:04 Ways To Increase Adrenaline, Epinephrine & Cortisol & Why That Is Good 00:35:00 Does Mindset During Stress Matter? 00:36:15 Protocols: Adrenaline Breathing Described 00:39:00 Practices To Increase Energy Without Increasing Stress 00:45:00 Using Stressors to ENHANCE Our Immune System: Science & Tools 00:55:11 Timing Thyroid Release For Energy 00:57:02 Adrenaline/Stress Increase Performance & Memory. IF They Are After Learning 01:02:45 An Optimal Learning Protocol 01:03:20 Coffee Changes Your Brain & Increases Connectivity Of “Anxiety Circuits” 01:05:43 Nootropics: Two Kinds, & How & Why They Work, “Neural Energy” 01:09:00 Biology of Comfort Foods: From Negative to Positive Feedback Loops 01:14:00 Bombesin: Energy Without Eating 01:15:00 How Stress Makes Our Hair Gray, & How To Prevent Stress-Induced Graying 01:18:05 Blunting Chronic Cortisol, Including: Ashwagandha & Science Of 01:25:50 Licorice Increases Cortisol & Blood Pressure, & Reduces Testosterone (by Glycyrrhizin) 01:28:50 Apigenin: Anti-Cortisol 01:29:53 Protocols For Optimizing Energy & Immune System Function (& Learning) 01:37:00 When Fasting, Exercise, Cold & Intense Breathing Become Detrimental 01:39:00 Prescription Compounds 01:39:47 Tools For Accessing Alert & Calm States of “Energy”: Separating The Brain & Body 01:42:11 Ways To Apply Knowledge Presented Today 01:43:20 No-Cost Ways To Support Us, Feedback, Sponsors, Patreon, Partners, “Office Hours” Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
3 Touko 20211h 42min
How to Control Your Metabolism by Thyroid & Growth Hormone
This episode discusses metabolism and how our thyroid hormone and growth hormone control our metabolism. I also clarify that metabolism isn't just about burning energy, it’s about converting energy from different sources into fuels for building and repairing our tissues such as muscle, brain, and tendons and mobilizing energy from body fat storage. I discuss the role of iodine, selenium, and salt for thyroid health, and how specific exercise protocols, amino acids and temperature can dramatically shift levels of growth hormone release in waking and in sleep. I also describe the current landscape of prescription compounds, peptides and other factors for changing levels of thyroid and growth hormone, and some of their risks. Throughout the episode, mechanisms and tools grounded in specific mechanisms are discussed. Supplements from Thorne https://www.thorne.com/u/huberman Timestamps (00:00:00) Introduction (00:06:05) Thyroid & Growth Hormone (00:08:44) Food Shapes: Do They Matter? (00:11:43) Stevia: Naming & Impact (00:13:30) Metabolism 101: Your Brain the Furnace (00:17:33) Releasing Hormones From Your Brain, Stimulating Hormones from Your Pituitary (00:21:04) Thyroid Hormone’s Real Effects: Growth, Repair and Energy Consumption of Tissues (00:22:45) Iodine, L-Tyrosine & Selenium: The Trio Essential For Thyroid Function (00:26:05) How Much Iodine Do We Need? By Food, Supplement or Ocean Air (00:28:09) Selenium For Thyroid: Brazil Nuts & Other Valuable Sources (00:33:05) Selenium For Pregnancy, Prostate Cancer Risk, Acne (00:35:20) “Clean Eating” Downsides: Cruciferous Vegetables, Leeching Iodine (00:39:00) Other Benefits of Iodine: Reducing Inflammation (00:41:00) Why & How Increased Thyroid Increases Metabolism (00:42:12) What To Eat To Support Your Brain (00:43:00) Hyperthyroidism (Too Much) & Hypothyroidism (Too Little) (00:44:35) Menstruation: Thyroid Carbohydrate & Sugar Craving (00:45:33) Ketogenic Diet & Its Effects On Thyroid, Rebound Weight Gain (00:48:39) Growth Hormone: What, Why & How (00:51:18) Growth Hormone (GH) Changes Across The Lifespan & Risks of GH Therapy (00:53:40) How To Powerfully Increase Growth Hormone: Know The Natural Triggers (00:54:49) Not Eating Within 2hrs of Sleep: Keep Blood Glucose Low(ish) At Sleep (00:55:43) Delta Wave Brain Activity Is the Trigger For Growth Hormone Release (00:58:25) LOW Doses of Melatonin Supplementation For Increasing GH Release (01:01:00) Book: Altered Traits, Binaural Beats? Delta Waves Access (01:04:35) Specific Types & Duration of Exercise That Stimulate Growth Hormone & Warmups (01:08:40) Keeping Low Blood Glucose & Ensuring A Cool Down For Two Phase GH Release (01:10:36) Sex Differences For WHEN During Exercise Growth Hormone and IGF-1 Release Occurs: Males Have To Last Longer (01:14:10) Supplements That Increase Growth Hormone 100-400% (or more): Arginine, Ornithine (01:18:20) Arginine & Exercise Together Can Be Counter-Productive (01:19:50) L-Citrulline Better For Arginine Than Arginine Itself (?!); & Blood Pressure Caution (01:23:09) Growth Hormone Changes Across The Lifespan: No One Escapes (01:26:00) Heat (& Cold) for Triggering Extremely Large Increases In Growth Hormone (01:29:20) Specific Heat Protocols For Increasing Growth Hormone: Up To 16-Fold (?!) (01:34:30) 2021 (New) Study: Heat Increases GH, & Lowers Cortisol, No Effects On Testosterone, DHEA Or Prolactin (01:36:00) Prescription Growth Hormone, & Emerging Peptides Therapeutics, Secretagogues Etc. (01:42:25) Synthesis, Summary Of Actionable Steps For Increasing GH and Thyroid Hormone (01:44:00) Zero Cost & Other Ways to Support Our Podcast; & Thank You! Learn more about your ad choices. Visit megaphone.fm/adchoices
26 Huhti 20211h 46min
How Hormones Control Hunger, Eating & Satiety
This episode I discuss how hormones from our gut, liver, pancreas and brain control our appetite--and the specific tools we can use to adjust those hormones in order to achieve specific goals. I explain the brain areas that control our desire to eat, and our desire to stop eating. I discuss a hormone we all can make that is regulated by UV-rays from sunlight that reduces our appetite. I also explain that when we eat controls our appetite and not the other way around (and how to leverage that fact). I describe how we are basically always eating until we reach a threshold level of fatty acids and amino acids in our gut and the factors that can alter that signaling and make us eat far more than we need. I also explain how insulin, glucose and glucagon work, why cholesterol is so key for ovary, adrenal, liver and testes function and how the ketogenic diet impacts glucose and thyroid levels. As always, I describe many tools: specific supplements, prescription compounds, specific types (and timing) of exercise to regulate hormones, specific timing and types of eating, ways to reduce sugar cravings by triggering release of the hormone CCK, and more. Note: A future episode will cover Thyroid hormone. Also, I mis-spoke when explaining POMC neurons. I said “P-M-O-C” but should have said “POMC”. Apologies. The name I gave for what POMC is, however, was correct: "proopiomelanocortin". Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Supplements from Thorne https://www.thorne.com/u/huberman Timestamps (00:00:00) Introduction (00:06:59) Hunger: Neural & Hormonal Control (00:08:32) Chewing & Hunger (00:11:05) Siamese Rats Reveal the Importance of Hormones In Hunger (00:13:08) Neurons That Powerfully Control Hunger by Releasing Specific Hormones (00:16:28) Anorexia & Extreme Overeating (00:16:57) Why Sunlight Suppresses Hunger: a-Melanocyte Stimulating Hormone (a -MSH) (00:20:03) Blue-blockers, Injecting a-MSH: Instant Tan & Priapism (00:22:30) Ghrelin: A Hormone That Determines When You Get Hungry, & That You Can Control (00:24:40) Meal Timing Determines Hunger, Not the Other Way Around (00:27:20) Satchin Panda, Circadian Eating & Intermittent(ish) Fasting (00:29:35) How To Rationally Adjust Meal Schedules: The 45min Per Day Rule (00:33:02) CCK (Cholecystokinin): A Hormone In Your Gut That Says “No Mas!” (00:34:55) Eating For Amino Acids, Fatty Acids & Sugar (00:39:05) L-Glutamine: Stimulates the Immune System & Reduces Sugar Cravings (00:43:42) Things To Avoid: Emulsifiers; Alter Gut Mucosa & Nutrient Sensing (00:49:32) “A Calorie Is NOT A Calorie” After All (00:52:36) Insulin & Glucose: Hyperglycemia, Euglycemia, & Hypogylcemia (00:56:12) The Order Your Eat Foods Matters: Managing Your Blood Glucose & Glucagon (01:02:40) Movement, Exercise & GLUT-4 (01:04:50) Why Sugar Stimulates Your Appetite (01:05:40) Keeping Blood Sugar Stable With Specific Exercises, The Power Of Insulin Sensitivity (01:07:55) High-Intensity Exercise, Glycogen & Metabolism (01:10:28) Cholesterol, HDL, LDL & Glucose Management: Ovaries, Testes, Liver, Adrenals (01:15:00) Prescription Compounds That Reduce Blood Glucose: Metformin (01:16:45) Berberine: A Potent Glucose Buffer That Also Adjusts Cholesterol Levels, Canker Sores (01:22:05) Chromium, L-Carnitine, Ginseng, Caffeine, Magnesium, Stevia, Vitamin B3, & Zinc (01:24:34) Acids: Vinegar, Lemons & Limes & False Alkalinity (01:26:40) Ketogenic Diets (In Brief): Effects On Blood Glucose, Thyroid Hormones (01:28:10) Diabetes, Filtering Blood, Sweet Urine (01:31:08) The Power of GLP-1 & Yerba Mate For Controlling Appetite, Electrolytes (01:35:19) Summary & Notes About Thyroid, Estrogen, Testosterone (01:37:20) Zero Cost & Sponsor-Based Ways To Support The Huberman Lab Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices
19 Huhti 20211h 39min
How to Optimize Testosterone & Estrogen
In this episode, I discuss testosterone and estrogen hormones and how they impact the brain, body, and behavior after puberty. I also discuss how various behaviors such as exercise (resistance and endurance training) and sex or observing sex impact these hormones and their levels. I ask: "what specifically is it about such activities that impact testosterone and estrogen?"; the resounding theme is that when our nervous system is activated in particular ways, it drives our endocrine system and vascular system to activate or repress certain hormone networks in predictable ways. I also discuss peer-reviewed studies and protocols addressing (at a mechanistic level) how light, cold and heat, and respiration (breathing) can positively or negatively impact testosterone and estrogen. We discuss specific supplements and compounds that peer-reviewed studies illustrate can adjust testosterone and estrogen levels by changing their binding to other proteins, raising them directly, or changing other hormones released from the brain and pituitary. I discuss optimization in the normal reference ranges for these hormones, and I discuss pheromones, apnea, menstrual cycles, menopause and andropause. Read the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://www.wakingup.com/huberman Timestamps 00:00:00 Introduction 00:00:26 Sponsors: AG1, LMNT & Waking Up 00:05:50 Hormone Optimization 00:07:00 Salutogenesis: A Powerful Way to Conceptualize Health 00:10:03 Estrogen and Testosterone: Sources, Levels and Ratios 00:15:46 The Power of Competition, Plus: Anxiety, Persistence and Dopamine 00:20:58 Testosterone and Libido Pre-Ovulation 00:21:48 Estrogen and Sexual Receptivity; Libido In Males 00:23:10 How Sex Behavior Impacts Testosterone: Observing vs. Actual vs. Abstinence 00:26:46 Testosterone and Prolactin: Sex Seeking vs. Pair Bonding 00:27:30 DHEA (dehydroepiandrosterone): Effects on Levels/Ratios 00:28:45 Behaviors That Decrease Testosterone (and Cortisol): Parenting and Prolactin 00:31:24 How Illness Impacts Testosterone and Estrogen: Cytokines, e.g., IL-6 00:33:20 How Exactly Do Behaviors Change Hormones? 00:34:18 Pheromones: Miscarriage, Menstrual Cycles, Puberty Onset, and Mate Recognition 00:43:33 Apnea: A Powerful Bi-Directional Influence On Estrogen and Testosterone 00:47:44 Mouth vs. Nose Breathing and Hormone Levels: Effects Via Sleep and Direct Effects 00:51:11 How Sleep Adjusts Cortisol/Testosterone and Cortisol/Estrogen Ratios 00:53:49 O2:CO2 Ratios, Nasal Breathing During Exercise 00:56:30 Light Viewing Patterns and Hormones: Dopamine, GnRH 00:57:44 Spring Fever: Tyrosinase, Hair Color, Mating Frequency 01:04:39 Specificity of Hormone Effects 01:06:03 Temperature: Cold and Hot Gonads 01:14:10 How To Exercise: Types, Effort Level, Sequencing 01:21:42 Cardio/Endurance vs. Resistance Training (First or Last?) Yes, It Matters 01:24:41 Estrogen and Menopause: Compounds That May Ameliorate/Reverse Symptoms 01:33:18 Nutrients That Optimize The Foundation For Hormones 01:36:00 Opioids as Severe Hormone Disruptors 01:37:23 Testes, Antlers and Ovaries 01:38:50 Creatine and Increasing DHT (Dihydrotestosterone) 01:40:14 Free and Bound Testosterone: SHBG (Sex Hormone Binding Globulin), Tongat Ali 01:43:23 Nettles, Prostate, Boron, and Blood Brain Barrier 01:45:27 Hormone Related Cancers: Sometimes Reducing Estrogen and Testosterone Is Optimal 01:47:43 Ecdysteroids: Mimic Mammalian Hormones 01:51:50 Optimizing Brain Hormones: Chorionic Gonadotropin, Fadogia Agrestis 01:57:18 Additional Compounds, Liver Toxicity, Overall Milieu 01:59:17 Summary: And Note About Additional Related Topic Coverage Coming Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
12 Huhti 20211h 58min
