S6 - E5 - Drug Development Week: FGF-21s, Cirrhosis, Resmiterom, Gene Therapies

S6 - E5 - Drug Development Week: FGF-21s, Cirrhosis, Resmiterom, Gene Therapies

Send us a text 00:00:00 - Surf's Up: Season 6 Episode 5 Host Roger Green briefly describes this episode’s three sections and introduces Roundtable guests. The Roundtable panel shares groundbreakers. 00:10:39 - Roundtable: A Deep Dive Into Drug Development, Part One The opening portion of this month's roundtable centers around two issues: exciting data for FGF-21s and, more generally, treating patients with cirrhosis. Naim Alkhouri sets the tone in his opening comments, which start by fo...

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S5 - E26.5 - Looking Back at #TLM2024 - Promoting Healthy Livers and Looking Ahead to 2025

S5 - E26.5 - Looking Back at #TLM2024 - Promoting Healthy Livers and Looking Ahead to 2025

Send us a text In this episode, Naim Alkhouri, Mike Betel, Michelle Long and Jeff McIntyre join Jörn Schattenberg and Roger Green to look back at The Liver Meeting 2024. This conversation reviews two sessions promoting healthy livers and asks panelists what they anticipate for #TLM2025. This last conversation starts with Jeff describing the session that moved him most and praising a panel that Mike co-chaired on Lifestyle Management of MASLD and MASH. Jeff spoke on this panel, and he descri...

3 Tammi 15min

S5 - E26.4 - Looking Back at #TLM2024 - Patient Advocacy and Patient-Centric Trials

S5 - E26.4 - Looking Back at #TLM2024 - Patient Advocacy and Patient-Centric Trials

Send us a text In this episode, Naim Alkhouri, Mike Betel, Michelle Long and Jeff McIntyre join Jörn Schattenberg and Roger Green to look back at The Liver Meeting 2024. This conversation considers the role of patient advocacy in replacing biopsy in clinical trials with NITs and reviews a session on the foundational principles for patien-centric clinical trials. This conversation picks up at the end of Michelle's discussion of the FDA Corner session. Jeff starts by identifying this specific...

3 Tammi 11min

S5 - E26.3 - Looking Back at #TLM2024 - FGF-21 Agents and the FDA Corner

S5 - E26.3 - Looking Back at #TLM2024 - FGF-21 Agents and the FDA Corner

Send us a text In this episode, Naim Alkhouri, Mike Betel, Michelle Long and Jeff McIntyre join Jörn Schattenberg and Roger Green to look back at The Liver Meeting 2024. This conversation reviews the late-breaker presentation on efimosermin, a q4w FGF-21 agent and the "FDA Corner" session. Jörn begins the discussion by highlighting a paper from the later breaker session on efimosfermin alfa, an FGF-21 agent dosed q4w. He notes that after only six doses (24 weeks), efimosfermin alfa dem...

2 Tammi 13min

S5 - E26.2 - Looking Back at #TLM2024 - Patient Genotyping and MASH Clusters

S5 - E26.2 - Looking Back at #TLM2024 - Patient Genotyping and MASH Clusters

Send us a text In this episode, Naim Alkhouri, Mike Betel, Michelle Long and Jeff McIntyre join Jörn Schattenberg and Roger Green to look back at The Liver Meeting 2024. This conversation considers how the anticipated approval of a second MASH drug without biopsy might affect clinical trials and discusses two recent publications on patient genotyping and patient clusters. The conversation starts with Roger asking the group whether the presence of two approved MASH medications that do not re...

2 Tammi 14min

S5 - E26.1 - Looking Back at #TLM2024 - Semaglutide Passes the ESSENCE Test

S5 - E26.1 - Looking Back at #TLM2024 - Semaglutide Passes the ESSENCE Test

Send us a text In this episode, Naim Alkhouri, Mike Betel, Michelle Long and Jeff McIntyre join Jörn Schattenberg and Roger Green to look back at The Liver Meeting 2024. This conversation reviews the ESSENCE trial, the Phase 3 trial demonstrating that semaglutide regresses fibrosis levels in some MASH patients. The conversation begins with each panelist sharing a word or short phrase they felt best captured their feelings about TLM2024. Next, panelists review the meeting's most conseq...

2 Tammi 13min

 S5-26 - One Month Later: Looking Back at MASLD/MASH Coverage From The Liver Meeting 2024

S5-26 - One Month Later: Looking Back at MASLD/MASH Coverage From The Liver Meeting 2024

Send us a text 00:00:00 – Surf’s Up: Season 5 Episode 26 - Last month, close to 8,000 hepatology stakeholders convened in San Diego for The Liver Meeting 2024. Hepatology Key Opinion Leader Naim Alkhouri, Novo Nordisk International Vice President for Medicines Michelle Long, and patient advocates Jeff McIntyre from the Global Liver Institute and Michael Betel from the Fatty Liver Alliance join Jörn Schattenberg and Roger Green to discuss highlights. 00:03:23 - Introduction and Groundbreaker...

20 Joulu 20241h 11min

S5 - E25 - Reviewing Expert Recommendations on the Use of Resmetirom

S5 - E25 - Reviewing Expert Recommendations on the Use of Resmetirom

Send us a text 00:00:00 - Surf's Up: Season 5 Episode 25 On July 20, Clinical Gastroenterology and Hepatology released the paper, Expert Panel Recommendations: Practical Clinical Applications for Initiating and Monitoring Resmetirom in Patients with MASH/NASH and Moderate to non-cirrhotic Advanced Fibrosis. Corresponding author Maru Rinella joins the Surfers to share key points from the recommendations and offer her thoughts on what lay behind them. 00:02:26 - Introduction and Groundbreaker...

9 Elo 202442min

S4 - E24.5 - SurfingMASH Question of The Week: Keys to Improving Provider-Patient Communication

S4 - E24.5 - SurfingMASH Question of The Week: Keys to Improving Provider-Patient Communication

Send us a text Two weeks ago, the SurfingMASH Question of the Week asked, "What structural or educational changes do you anticipate will significantly improve Provider-Patient communication? Will these changes require more from the provider and more from the patient?" Today, S5 E23 panelists Mike Betel and José Willemse join Roger Green to review the three answers we received. Of the three questions from audience members, one from a patient/patient advocate suggested greater honesty, b...

8 Elo 202420min

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