MRI-Guided Focused Ultrasound and the Delivery of Therapeutics to the Brain

In this podcast, first recorded at the 2nd annual Drug Delivery West conference, Dr Isabelle Aubert, University of Toronto, provides an introduction to MRI-guided focused ultrasound (MRIgFUS) and reviews applications in preclinical models of neurodegenerative disorders where therapeutic molecules, gene therapy vectors, and progenitor cells are injected intravenously and delivered from the blood to targeted areas of the brain with MRIgFUS. Dr Aubert will describe the seminal work of the Sunnybrook team on MRIgFUS-BBB modulation, without exogenous therapeutic, leading to glial plasticity, amyloid pathology reduction, hippocampal neurogenesis and improved cognitive functions in a preclinical model of Alzheimer's disease. To learn more about the 3rd annual Drug Delivery West conference happening May 17-18, 2021 in San Francisco, CA please visit www.drugdeliverywest.org