A Grand, Unified Theory of Why Americans Are So Unhealthy

A Grand, Unified Theory of Why Americans Are So Unhealthy

Americans are unusually overweight and chronically ill compared to similarly rich countries. This episode presents a grand, unified theory for why that's the case. Our food environment has become significantly more calorie-rich and industrialized in the past few decades, sending our obesity rates soaring, our visceral fat levels rising, and our chronic inflammation surging. The result is an astonishing rise in chronic illness in America. That's the bad news. The good news is that GLP-1 drugs, like Ozempic and Zepbound, seem to be astonishingly successful at reversing many of these trends. This episode blends two interviews with Dr. David Kessler and Dr. Eric Topol. Kessler was the commissioner of the Food and Drug Administration under the Bush and Clinton administrations, from 1990 to 1997. He helped lead Operation Warp Speed in its final months. He is the author of the book 'Diet, Drugs, and Dopamine.' Topol is a cardiologist and the founder and director of the Scripps Research Translational Institute. He is the author of the book 'Super Agers.' If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guests: Dr. David Kessler and Dr. Eric Topol Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Megapod: The Crisis in American Science

Megapod: The Crisis in American Science

Today, we are witnessing an unprecedented assault on American science. Thousands of workers have been dismissed from the National Institutes of Health and the National Science Foundation. Billions of ...

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Is This the Chinese Century?

Is This the Chinese Century?

In the last few weeks, for the first time in my life, I’ve seriously thought about the 21st century not being another American century. A recent essay in the journal Foreign Affairs by Rush Doshi and...

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What Americans Get Wrong About ADHD

What Americans Get Wrong About ADHD

In 1937, a Rhode Island psychiatrist named Charles Bradley ran an experiment on 30 child patients who had complained of headaches. He gave them an amphetamine, that is a stimulant, called Benzedrine, ...

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An Astrophysicist Explains the "Strongest Evidence Yet" of Alien Life

An Astrophysicist Explains the "Strongest Evidence Yet" of Alien Life

Last week, a team of astrophysicists from the University of Cambridge announced that they had discovered the “strongest indication” ever of extraterrestrial life. The source did not come from Mars or ...

22 Huhti 20251h 4min

A Toy Manufacturer Explains How Trump’s Tariffs Could Crush His Industry

A Toy Manufacturer Explains How Trump’s Tariffs Could Crush His Industry

In the past three weeks, we've spoken to economists about the tariffs. We’ve spoken to a historian about the Smoot-Hawley Tariff Act and the 100-year legacy of American protectionism. We've spoken to ...

17 Huhti 202533min

Why America Will Lose Its Trade War With China

Why America Will Lose Its Trade War With China

The U.S. is in the opening innings of a full-blown trade war with China. What does that actually mean? What do we sell to China? What does China sell to us? How is each country dependent on the other ...

16 Huhti 202543min

Plain History: The Smoot-Hawley Tariff and the Great Depression

Plain History: The Smoot-Hawley Tariff and the Great Depression

The 1920s and the 2020s share a special kinship. One hundred years ago, the U.S. was grappling with a mix of growth, technological splendor, and generational anxiety—a familiar cocktail (albeit, from ...

11 Huhti 202550min

Trump’s Trade War Is Like Nothing America’s Ever Seen

Trump’s Trade War Is Like Nothing America’s Ever Seen

Donald Trump's tariff plan has set global markets on fire. What are they for? What are they trying to accomplish? Fresh off his black-out-rage session on CNBC, Derek talks to Matthew Klein, the autho...

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