Two Years Later, We Still Don’t Understand Long Covid. Why?
The Ezra Klein Show21 Kesä 2022

Two Years Later, We Still Don’t Understand Long Covid. Why?

Depending on the data you look at, between 10 and 40 percent of people who get Covid will still have symptoms months later. For some, those symptoms will be modest. A cough, some fatigue. For others, they’ll be life-altering: Debilitating brain fog. Exhaustion. Cardiovascular problems. Blood clotting.

This is what we call long Covid. It’s one term for a vast range of experiences, symptoms, outcomes. It’s one term that may be hiding a vast range of maladies and causes. So what do we actually know about long Covid? What don’t we know? And why don’t we know more than we do?

Dr. Lekshmi Santhosh is an assistant professor at UCSF Medical Center, and the founder and medical director of UCSF’s long Covid and post-ICU clinic. Her clinic opened in May 2020 and was one of the first to focus on treating long Covid patients specifically. We discuss the wildly broad range of symptoms that can qualify as long Covid; the confusing overlaps between Covid symptoms and other diseases; whether age, race, sex and pre-existing conditions affect a person’s chances of contracting long Covid; why it’s so difficult to answer a seemingly simple question like, “How many people have gotten long Covid?”; what to make of a recent study that seemingly undermines the biological existence of long Covid; how worried we should be about correlations between Covid and medical disasters like heart attacks, strokes and abnormal blood clotting; and more.

Mentioned:

Post–COVID Conditions Among Adult COVID-19 Survivors Aged 18–64 and ≥65 Years — United States, March 2020–November 2021” by Lara Bull-Otterson, Sarah Baca1, Sharon Saydah, Tegan K. Boehmer, Stacey Adjei, Simone Gray and Aaron M. Harris

Long COVID after breakthrough SARS-CoV-2 infection” by Ziyad Al-Aly, Benjamin Bowe and Yan Xie

A Longitudinal Study of COVID-19 Sequelae and Immunity: Baseline Findings” by Michael C. Sneller, C. Jason Liang, Adriana R. Marques, et al.

Positive Epstein–Barr virus detection in coronavirus disease 2019 (COVID-19) patients” by Ting Chen, Jiayi Song, Hongli Liu, Hongmei Zheng and Changzheng Chen

Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app” by Michela Antonelli, Rose S. Penfold, Jordi Merino, Carole H. Sudre, Erika Molteni, Sarah Berry, et al.

Understanding and Improving Recovery From COVID-19” by Aluko A. Hope

Markers of Immune Activation and Inflammation in Individuals With Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection” by Michael J. Peluso, Scott Lu, Alex F. Tang, Matthew S. Durstenfeld, et al.

Book Recommendations:

In Shock by Dr. Rana Awdish

Every Deep-Drawn Breath by Wes Ely

Mountains Beyond Mountains by Tracy Kidder

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Thoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.

You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast, and you can find Ezra on Twitter @ezraklein. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.

“The Ezra Klein Show” is produced by Annie Galvin, Jeff Geld and Rogé Karma; fact-checking by Haylee Millikan and Michelle Harris; original music by Isaac Jones; mixing by Jeff Geld; audience strategy by Shannon Busta. Our executive producer is Irene Noguchi. Special thanks to Kristin Lin, Kristina Samulewski, Dr. Ziyad Al-Aly and Lauren Nichols.

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The Man With the Plan to Beat the Pandemic

The Man With the Plan to Beat the Pandemic

I’ve never covered a moment that simultaneously merits so much despair and so much hope. It’s dizzying. The Biden administration takes office with over 25 million Covid-19 cases nationwide, over 420,000 Americans dead, and new, highly contagious variants of the virus stalking our future. It’s as grim a situation as I’ve seen.But for the first time, we can do more than hide. We can immunize. Getting a population of 330 million to herd immunity is a hellishly difficult undertaking in the best of circumstances, and these are not the best of circumstances. Still, speed matters: Getting to herd immunity a few months faster could save hundreds of thousands of lives.Dr. Vivek Murthy was surgeon general under Barack Obama, and is Joe Biden’s nominee for the same position. He’s also co-chair of Biden’s coronavirus task force.In this episode, Murthy walks me through the Biden administration’s plan to beat the coronavirus. We discuss America’s botched vaccine rollout efforts, what the choke points are now, whether the Oxford-AstraZeneca and Johnson & Johnson vaccines will be approved, why the U.S. government should be shipping out free masks, what’s blocking 24/7 vaccination sites, the F.D.A.’s overly conservative approach to at-home testing kits, what we can and can’t do after getting the vaccine, the vaccine failures in blue states, how to change the minds of the nearly third of Americans who are vaccine-skeptical, why persuasion is as much about listening as talking, the new coronavirus variants, and much more.You can find transcripts (posted midday) and more episodes of "The Ezra Klein Show" at nytimes.com/ezra-klein-podcast, and you can find Ezra on Twitter @ezraklein.Thoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.“The Ezra Klein Show” is produced by Rogé Karma and Jeff Geld; fact-checking by Michelle Harris; original music by Isaac Jones; mixing by Jeff Geld. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

26 Tammi 20211h 20min

Coming Soon: The Ezra Klein Show

Coming Soon: The Ezra Klein Show

Every Tuesday and Friday, Ezra Klein invites you into a conversation about something that matters. How do we address climate change if the political system fails to act? Has the logic of markets infiltrated too many aspects of our lives? What is the future of the Republican Party? What do psychedelics teach us about consciousness? What does sci-fi understand about our present that we miss? Can our food system be just to humans and animals alike?Subscribe wherever you listen to podcasts.You can find transcripts (posted midday) and more episodes of "The Ezra Klein Show" at nytimes.com/ezra-klein-podcast, and you can find Ezra on Twitter @ezraklein.Thoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.“The Ezra Klein Show” is produced by Rogé Karma and Jeff Geld; fact-checking by Michelle Harris; original music by Isaac Jones; mixing by Jeff Geld. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

13 Tammi 20212min

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