COULD THIS NEW NON-OPIOID COMPLETELY REPLACE FENTANYL? | EP 42
Atomic Anesthesia15 Heinä 2025

COULD THIS NEW NON-OPIOID COMPLETELY REPLACE FENTANYL? | EP 42

Discover the future of pain management on this episode of Atomic Anesthesia as we explore a major breakthrough: the FDA approval of suzetrigine, a first-in-class, nonopioid pain medication. Guided by cutting-edge research and expert editorial insight from Anesthesiology, we dig into how suzetrigine works—targeting the NaV1.8 sodium channel in peripheral nerves—and what this means for patients and providers facing acute pain. You’ll hear about the pivotal NAVIGATE clinical trials, real-world patient experiences, and the medication’s advantages over traditional opioids, including fewer side effects and no risk of addiction. Whether you’re a healthcare professional, patient, or someone passionate about medical innovation, join us to learn how suzetrigine is poised to reshape pain relief and help bridge the gap left by the opioid crisis.

References:

  1. Bertoch T, D'Aunno D, McCoun J, Solanki D, Taber L, Urban J, Oswald J, Swisher MW, Tian S, Miao X, Correll DJ, Negulescu P, Bozic C, Weiner SG. Suzetrigine, a Nonopioid Na V 1.8 Inhibitor for Treatment of Moderate-to-severe Acute Pain: Two Phase 3 Randomized Clinical Trials. Anesthesiology. 2025 Jun 1;142(6):1085-1099. doi: 10.1097/ALN.0000000000005460. Epub 2025 Mar 21. PMID: 40117446; PMCID: PMC12061372.
  2. Rathmell JP, Clark JD, Eisenach JC. Suzetrigine: First in a New Class of Nonopioid Analgesics for Acute Pain. Anesthesiology. 2025 Jun 1;142(6):989-991. doi: 10.1097/ALN.0000000000005465. Epub 2025 May 13. PMID: 40358331.

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PERIPHERAL VASCULAR DISEASE & VASCULAR ANESTHESIA (PART 2) │ EP59

PERIPHERAL VASCULAR DISEASE & VASCULAR ANESTHESIA (PART 2) │ EP59

In this episode of the Atomic Anesthesia Podcast, host Dr. Rhea Temmermand is joined by vascular anesthesia expert Rick Heuermann, DNP, MBA, CRNA, to unravel the complex pathophysiology of peripheral ...

23 Loka 202530min

PERIPHERAL VASCULAR DISEASE & VASCULAR ANESTHESIA (PART 1) │ EP58

PERIPHERAL VASCULAR DISEASE & VASCULAR ANESTHESIA (PART 1) │ EP58

In this episode of the Atomic Anesthesia Podcast, host Dr. Rhea Temmermand is joined by vascular anesthesia expert Rick Heuermann, DNP, MBA, CRNA, to unravel the complex pathophysiology of peripheral ...

20 Loka 202524min

WHY ARE MY EXTUBATIONS SO SLOW? │ EP57

WHY ARE MY EXTUBATIONS SO SLOW? │ EP57

In this episode of the Atomic Anesthesia Podcast, nurse anesthesia residents are guided through the pivotal moments of emergence and extubation—recognized as one of the riskiest steps in the operating...

16 Loka 202516min

PHARMACOGENETICS: WHY DRUG RESPONSES DIFFER IN A POPULATION OF PEOPLE │ EP56

PHARMACOGENETICS: WHY DRUG RESPONSES DIFFER IN A POPULATION OF PEOPLE │ EP56

This is a joint episode recorded with Dr. Chloe Gomez of the My Favorite Learner podcast. This episode explores the foundational concepts of pharmacogenetics and its impact on drug responses during an...

13 Loka 202543min

MULTIMODAL, PREEMPTIVE AND NEXT-GEN ANALGESIA WITH JR PHILLIPS  | EP55

MULTIMODAL, PREEMPTIVE AND NEXT-GEN ANALGESIA WITH JR PHILLIPS | EP55

This episode of the Atomic Anesthesia Podcast explores the emerging role of Suzetrigine, a novel non-opioid NaV1.8 channel inhibitor, in multimodal surgical pain management. Host Rhea and guest JR Phi...

6 Loka 202520min

TRAUMA ANESTHESIA SERIES (PART 10): BURN PATIENTS | EP 54

TRAUMA ANESTHESIA SERIES (PART 10): BURN PATIENTS | EP 54

In the final installment of the Trauma and Burn Anesthesia Series, we explore the unique physiology and management of burn patients, a population that differs significantly from blunt or penetrating t...

2 Loka 202529min

TRAUMA ANESTHESIA SERIES (PART 9): MASS CASUALTY | EP 53

TRAUMA ANESTHESIA SERIES (PART 9): MASS CASUALTY | EP 53

In part 9 of the Trauma Anesthesia Series, we dive into the critical topic of mass casualty events—what defines them, how hospitals respond when resources are overwhelmed, and the principles of patien...

29 Syys 202516min

TRAUMA ANESTHESIA SERIES (PART 8): PREGNANT, PEDIATRIC & GERIATRIC POPULATIONS | EP52

TRAUMA ANESTHESIA SERIES (PART 8): PREGNANT, PEDIATRIC & GERIATRIC POPULATIONS | EP52

Welcome to part 8 of the Trauma & Burn Anesthesia Series. In this episode, we take a broad look at special populations in trauma anesthesia—pregnant, pediatric, and geriatric patients. Each of these g...

25 Syys 202514min

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