#354: The DARK Side of Bodybuilding: Eating Disorders, Cellular Health & Peptide Power—How Dylan Gemelli Rebuilt Everything

Dr. Szyf is a pioneer in the field of epigenetics, he holds a PhD from the celebrated Hebrew University, a postdoctoral  fellowship in Genetics at Harvard Medical School, a Professorship at McGill University and a Chair in Pharmacology at GlaxoSmithKline. 5:33 DNA as the operating system of our lives   6:14 Disease causes disruption in the DNA   6:41 DNA methylation gives us an insight into what’s going on in our DNA   7:07 Epi Age testing can tell us how many years we’ve been living in this world, and may give insight into how many years we may have left   8:02 Chronological age and epigenetic age can be good indicators for life span   11:17 Epi Age is a lifestyle product   12:59 Identifying the markers for aging   14:23 How Epi Age is different    17:05 What are the most effective ways to slow down the clock?   17:29 Behaviours that can help slow down the clock   18:28 epiAging app   19:51 epiAge test results tell you what you’re DNA thinks of what you’re doing   22:21 The first step in slowing down the clock is to get to a state of balance   23:58 Using AI to derive some conclusions from an individual result against a general lifestyle model   24:30 The great revolution will come from mathematics and technology to capture the complexity of humans   26:24 The idea of sharing -- creating a “Waze” of health   27:08 Health data safety and privacy   28:06 Balancing privacy and sharing -- learning about diseases without consequences to the individual   29:00 Sharing public methylation data can help save millions of lives   31:19 Firewalled personal data and medical data  -a solution to protect the individual   32:25 Goal: To get the best solutions to prevent anyone to hack the database   33:41 The collaboration between Epi-Age and users    36:41 The best way to use the Epi-Age test   40:25 Transferring the responsibility of health from your doctor to yourself   40:45 Experience as a teacher   41:10 Trial, error, and scientific truth   41:36 Self-empowerment and the biohacking movement   43:22 Technology empowers people about medicine   44:37 epiAge app as a source of information for lifestyle trends   48:11 Environmental influence on genetics   49:38 The impact of your mental environment on your health   50:02 Listen to your own clock   Ordering tests: Epi-Age.com Use Promo code Longevity to get 10% off the cost of your test….   Link to Dr Szyf’s Ted Talk:  https://youtu.be/38OUCtzkT4Q   Please note that this content  is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Before changing your diet or using any new supplement make sure to consult with your health care provider.  Always seek the advice of your physician or health care provider with any questions or concerns you may have regarding a medical condition before you make any changes.

26 Loka 202055min

Dr. Amber is an A4M trained peptide expert and Naturopathic Doctor practicing out of beautiful California.  In this episode we talk about two peptides that address mitochondria and why that’s an amazing place to start with peptides. Dr. Amber uses the term “forgot” which you’ll learn why towards the end of the show, and how to remind your body of proper signaling and why peptides are so amazing!   Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your health care provider. Always seek the advice of your physician or health care provider with any questions or concerns you may have regarding a medical condition before you make any changes.   1:30 Why we start with MITOCHONDRIA   2:15 Theory of aging   3:15 A4M   5:25 The issue with the thought of “getting energy from energy drinks” you are an energy factory    6:45 Why issues show up in the brain and heart first   9:00 The link between Fibromyalgia and mitochondrial dysfunction   10:00 Inflammation, why it needs to be addressed first so that one can then add things like peptides to help with repair   11:00 How common analgesics (pain relief pills) negatively affect mitochondria    12:30 How blue light negatively affects melatonin production   13:10 Things that damage the mitochondria.   13:20 How to create new mitochondria   13:45 Why sleep is so important   15:00 Ways to mitigate damage, there are amazing things you can do :)   15:20 Computer software to reduce blue light and protect your eyes and mitochondria    16:30 Offset the positive ions with negative ions by going to a natural body of water or grounding    17:00 Red light can upregulate production of ATP and mitochondria    19:30 Cold water exposure    21:30 Why Nathalie likes cold lakes over a tub 😂 22:15 Our cells make waste naturally, not including environmental factors, that’s normal. This is why we need to support detoxification   23:00 Leveraging hormetic stressors. LDN and adaptation principle to your benefit.   23:40 Molecular hydrogen, because we need oxidation, but this works almost like an adaptogen    24:45 HIIT workouts for the win!   25:00 Cell senescence   27:00 SS31   28:20 May be useful for - cardiac issues, insulin/pancreatic dysfunction, depression, fibromyalgia, chronic fatigue, anti-aging.    30:15 Amount needed of SS31.    33:00 Our bodies make these peptides, but often “need instructions” or a reminder...   34:30 How the wrong peptide at the wrong time can do more harm than good, and the right peptide at the right time can really do wonders and promote signaling that the body really needed and “forgot” about.   37:00 Melanotan    39:00 Nutrition is incredibly important, but here’s why you often need help from peptides   40:10 5-Amino-1MQ (capsule, no needle use)    41:50 How 5-Amino-1MQ keeps your NAD around longer   42:50 L-carnitine    43:30 Dosing of 5-Amino-1MQ   44:00 How some people react very different, triggering more anxiety   46:00 Sublingual NAD powder that Nathalie loves   47:10 The placebo of peptides and supplements and the power of belief    48:45 The issue with digesting supplements    49:15 Leaky gut    50:30 NAD The patch versus IV, and why you can get more from the patch!   52:30 Kisspeptin peptide, for men vs. women,  “kiss-54” “kiss-10”   55:45 Natural increase of testosterone    56:00 Why Dr. Amber uses the term “forgot”...and how to remind your body of proper signaling    57:00 And why you should avoid exogenous testosterone for as long as possible    57:45 Kiss-54   https://www.instagram.com/doctorambernd/ drambernd.com

16 Loka 20201h 3min

Dr. Yurth is on the cutting edge helping her clients prevent joint replacement with the use of peptides, hormones and preventative medicine. She’s an expert on circadian rhythm and how to fix yours with peptides and other biohacks!  Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your health care provider. Always seek the advice of your physician or health care provider with any questions or concerns you may have regarding a medical condition before you make any changes.   http://boulderlongevity.com/   3:13 Dr. Yurth Background    12:00 industry is about lifelong learning and questioning what we thought we knew   14:00 Take responsibility for your own   15:00 Why Nathalie and Dr. Yurth would rather spend money on their than a fancy   16:00 How you shouldn’t expect a peptide to do ALL of the work for you   19:00 Peptides and your Circadian rhythm and deep and REM sleep.   20:54 The best time to have surgery   22:00 The Clock Gene   22:29 How do we fix the circadian rhythm in you   24:50 How this sleep tracker shows you the impact of your actions    25:50 How to increase deep sleep time “the brain cleanout time”   26:21 If you’re frustrated that these biohacks aren’t “helping you”    26:10 Sleep quality vs. quantity, and how too much sleep can be bad, and what really matters most   28:55 How DSIP could be better for some people in the morning for sleep that night, and great for some in the evening.    31:50 Muscle building    34:30 The other benefits of melatonin   37:33 Stacking and why you should give something a chance    38:30 Biohacking for night shift workers, must biohack   40:25 Why you should take melatonin, and if you’re a slow metabolizer of melatonin listen to this!   46:15 How most disease can be linked back to circadian rhythm    50:39 How being breast fed vs. bottle fed and how timing of feeding affects children    54:30 Neuropathy    56:07 Kidney function   56:24 Fibromyalgia    59:32 Pulsing: turning on, turning off, turning on, turning off   59:55 How long to try a peptide for   http://boulderlongevity.com/ https://www.instagram.com/dryurth/

6 Loka 20201h 5min

Thaddeus Owen the co founder and owner of PrimalHacker has been deep diving into how light and EMF's affect our health and physiology for almost as long as I've known him. He is a wealth of information on the topic and in this episode we deep dive into the many issues impacting our health and, more importantly what we can do about it. For the most part we stick to easy and free interventions you can apply starting today - and we even mention a peptide in our conversation! PrimalHacker sells a curated selection of items that can help you to live a healthier light life including Blue Blockers, Red Lights and more - all at incredibly affordable prices. PLUS you can use Promo Code NAT10 to get an extra 10% off your entire purchase! Please note that this video is for information purposes only and that none of the information in this video is intended as medical advice. Please consult with your health provider before starting any new intervention and especially if you have a medical condition.   Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your health care provider. Always seek the advice of your physician or health care provider with any questions or concerns you may have regarding a medical condition before you make any changes.

25 Syys 20201h 5min

In this Interview, Jean-Francois Tremblay, owner of CanLab and I dig in to one of the new darlings of the peptide world - Tesamorelin and a less known but possibly just as effective other option - Setmelanotide - an offshoot of the better known Melantonan 2. We also cover AOD 9604, FRAG 17691 and CJC1295 ...and why you probably want to avoid the version with DAC (drug affinity complex)... We start with a chat about how if you're after lasting results there's really no way to avoid optimizing your diet, moving more, optimizing sleep etc... but these peptides might just help to speed things along and ease some of the bumps along the way. Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your health care provider. Always seek the advice of your physician or health care provider with any questions or concerns you may have regarding a medical condition before you make any changes. Show Notes: Keto Calorie Peptides Help with Fat Loss Body Recomposition Growth Hormone unregulated by Fat Loss peptides like FRAG 17691 or AOD9604 (just one amino acid difference) help to mobilize fatty acids in the fat cell – but need to be in calorie/energy deficit for it to stay out Consistency and sticking to your plan is the ultimate secret sauce…   Why Canlab combines Frag and AOD 9604 More about Frag and AOD….are they the same or different? AOD lacks one tyrosine…means that it lasts longer…whereas Frag uses more up front and gets metabolized faster….. Tesamorelin…..what it does…. The skinny on Tesamorelin….it’s not about Tesa it’s about the growth hormone release…. Re Muscle Gains attributed to Peptides….in studies re old people it’s about bringing back muscle you once had…. Hormone replacement therapy is at the foundation of reclaiming muscle mass GH good for muscle sustaining (vs growth) and tissue repair (but doesn’t hold a candle to BPC and TB4) Tesamorelin – origins – where it came from originally….very close to CJC 1295 (Mod IGRF 121 is actually CJC 1295 without dac). and other Growth Hormone Secretagogues. The difference between Tesa and CJC not really all that great….why some people may be promoting Tesa over CJC 1295 the magic is in the dose. Difference about with Dac and without Dac. With Dac too many peaks of growth hormone (similar to MK 677….increases risk of insulin resistance…..why is the Dac long lasting…binds to albumin in the blood ….which is problematic as there may have been relationship to blood cancer seen in certain studies….so better to use without DAC…just use multiple times a day if necessary  Post workout (3) is a good time…but pre bed(1), pre workout and first thing in the morning (2) are all better    Setmelanotide – another derivative of alpha MSH (Melanotan, melanotan 2, PT141) Basically prioritizes appetite suppression over tanning and sexual enhancement..they all create a tan just to varying degrees…. SM get appetite curbing (some sexual stim)…increases metabolic rate by about 6%, without increasing HR or BP…. On average can expect about 1 lb a week fat loss…. Many reports of people using it with good results – safe track record…..Clinical studies went for 12 months   Do not start at full dose of 1.5mg a day….start at .5 1-2 days then 1.0mg for a couple of days and then increase to full dose to avoid possible /nausea In studies – they changed nothing else….and saw results but it’s likely that as people lost weight they may have started to move more etc… At this point best method for most peptides is SubQ over oral….Intranasal may work but need to use higher dose (aka PT141 1 mg is SubQ and 2mg is IntraNasal)   Tesofensine – not a peptide acts on dopamine and AC receptors in the brain so needs to be used with great caution Please note that this video is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your care provider. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition.

25 Syys 202052min