The Hidden Threat: Ureaplasma's Impact on IVF Success

If you've been trying to conceive with low AMH, high FSH, diminished ovarian reserve (DOR), or poor egg quality and nothing seems to be working… or if you've experienced failed IVF cycles or unexplained pregnancy loss - this episode is for you.

We're diving into one of the most overlooked infections that could be silently impacting your fertility: Ureaplasma. This commonly missed microbe can compromise egg quality, disrupt implantation, and contribute to early miscarriage, even when labs appear "normal."

Whether you're TTC naturally or preparing for an IVF or FET cycle, you'll learn:

• How Ureaplasma affects egg and embryo quality, implantation, and ovarian reserve
• Why this infection is often missed on standard fertility workups
• The importance of partner testing and treating both partners
• When and how to test for Ureaplasma
• The functional fertility approach we use at Fab Fertile to rebalance the vaginal and seminal microbiome for optimal conception

If you've done "all the things" and still aren't seeing results, this episode may reveal a missing piece of your fertility puzzle.

This episode is for you if:

• You're struggling to conceive naturally despite doing "all the right things."
• You've had failed IVF transfers, poor egg quality, or low ovarian reserve without clear answers.
• You've experienced recurrent infections or unexplained pregnancy losses.

5 Key Points:

• Why Ureaplasma and Mycoplasma are often missed in standard fertility testing and why they matter for egg quality, implantation and pregnancy maintenance.
• How Ureaplasma can contribute to low AMH, high FSH, and diminished ovarian reserve by increasing inflammation in the reproductive tract and altering the vaginal microbiome.
• The link between Ureaplasma and recurrent miscarriage, failed IVF, and abnormal embryos, even when other tests are "normal".
• The functional fertility approach to addressing Ureaplasma with targeted antimicrobials, vaginal microbiome restoration, and gut health support for natural and assisted conception.

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TIMESTAMPS

[00:00:00] Intro: Ureaplasma's hidden role in fertility struggles, natural conception, failed IVF, low AMH, DOR, poor egg quality, and unexplained pregnancy loss.

[00:01:00] Who this episode is for: Fertility challenges including low AMH, high FSH, DOR, RPL, recurrent infections, and unexplained infertility.

[00:02:00] What is ureaplasma? Impact on vaginal and seminal microbiome, egg and sperm quality, inflammation, and implantation failure.

[00:03:00] Who should get tested? Those with unexplained infertility, recurrent pregnancy loss, persistent infections, elevated CRP/ANA, poor IVF outcomes, or partner infection history.

[00:04:00] Why microbiome testing matters: Gut, vaginal, and seminal microbiome panels uncover hidden infections missed by conventional testing.

[00:05:00] Key red flags: Multiple failed IVF transfers, RPL after heartbeat confirmation, chronic vaginal/urinary symptoms, and abnormal semen analysis.

[00:06:00] Testing methods: Functional medicine/nutrition, PCR, and microbiome panels (e.g., Juno Bio) versus limited conventional testing.

[00:07:00] Supporting Fertility Success: Using biofilm disruptors and restoring balance in gut and vaginal microbiomes to improve egg quality and IVF outcomes.

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How to Get Started With Functional Fertility Support

Book your call here to get your personalized plan and options to help improve pregnancy success either naturally or with IVF treatment.

Check out our Fab Fertile functional fertility program here and learn how to improve AMH levels naturally. We work with couples that have low AMH, high FSH, diminished ovarian reserve, premature ovarian insufficiency, and recurrent pregnancy loss.

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RESOURCES

Before Your IVF Transfer, Test This First: https://fabfertile.com/blogs/podcasts/before-your-ivf-transfer-test-this-first?_pos=4&_sid=c1bed4027&_ss=r

IVF Prep with Low AMH: Boosting Your Chances for Success: https://fabfertile.com/blogs/podcasts/ivf-prep-with-low-amh-boosting-your-chances-for-success-1?_pos=1&_sid=2685fd59c&_ss=r

Causes of Miscarriage Before 12 Weeks: What Most Doctors Miss: https://fabfertile.com/blogs/podcasts/causes-of-miscarriage-before-12-weeks-what-most-doctors-miss

What You Need To Know About Chronic Infections And Infertility: https://fabfertile.com/blogs/podcasts/what-you-need-to-know-about-chronic-infections-and-infertility?_pos=2&_sid=1142152ce&_ss=r

Our favorite fertility tracker Inito (use code FABFERTILE15 to save 15)

Studies

Today's study looks at Ureaplasma urealyticum, a common genital tract infection, and how it affects IVF. Researchers found it didn't affect fertilization or embryo quality but was linked to lower pregnancy rates after embryo transfer. The culprit? Infection in the endometrial lining which can disrupt implantation. So even if embryos look good Ureaplasma can still sabotage IVF success. https://academic.oup.com/humrep/article-abstract/6/5/727/609246?redirectedFrom=fulltext

This study looked at whether Ureaplasma urealyticum in men's semen affects IVF. The results? Fertilization and pregnancy rates were the same for infected and uninfected men. But here's the thing, miscarriage rates were much higher in couples where the male partner had the infection. So Ureaplasma might not stop you from getting pregnant but it can increase the risk of losing the pregnancy. https://www.fertstert.org/article/S0015-0282(98)00472-5/fulltext

Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH

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💛 Join my free Facebook group: Get Pregnant Naturally With Low AMH and/or High FSH: https://www.facebook.com/groups/451444518397946

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Please note we only promote products that Sarah Clark or her Fab Fertile team has tried and believes are beneficial for someone who is TTC. We may receive a small commission.