Inside Rett syndrome with Prof. Nicoletta Landsberger

In episode seven of our Neuroscience Research series, Filippo Dall'Armellina and Dr. Michael Cearns speak with Dr. Nicoletta Landsberger from the University of Milan. Her research focuses on Rett syndrome: a rare, severe X-linked neurodevelopmental disorder and a leading cause of intellectual disability in females. They discuss how the disease progresses in Mecp2-deficient mice, the therapeutic potential of neural precursor cell transplants, and a promising non-invasive treatment strategy: intranasal delivery of nerve growth factor. Research Highlights from the Episode: - Paper 1: Carli et al. A comprehensive longitudinal study of magnetic resonance imaging identifies novel features of the Mecp2-deficient mouse brain. Neurobiology of Disease, 2023. PMID: 36931532. - Paper 2: Frasca et al. Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway. EMBO, 2024. PMID: 39496971. - Paper 3: Pozzer et al. Clinical-grade intranasal NGF fuels neurological and metabolic functions of Mecp2-deficient mice. Brain, 2025. PMID: 39300821. 🧠 #NeuroscienceResearch X/Twitter: @NPodcases Visit the Neuro Podcases website: neuropodcases.co.uk