175. AMA: Glyphosate, Sunning your balls, and APOE4

175. AMA: Glyphosate, Sunning your balls, and APOE4

On today’s Ask Me Anything episode, Paul answers listener questions about APOE4, glyphosate, and his thoughts on sunning your testicles!

A note from Paul: Throughout my training and practice as a physician, I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey.

Time Stamps:

00:00:00 Heart & Soil testimonial

00:06:20 Podcast begins

00:07:30 A review of Paul’s bloodwork panel

00:11:30 Is there research behind sunning our testicles?

00:19:21 Should we worry about glyphosate?

00:29:30 Can we avoid glyphosate altogether?

00:31:10 Should we worry about APOE4?

00:41:30 Paul’s thoughts on depression and depression medication

00:46:50 Why Paul is not a fan of nootropic supplements

00:48:15 Gallbladder and liver health

00:51:45 Questions about animal-based eating. How strict do we have to be? How much fruit and honey is too much? How can we eat animal-based while traveling?

00:57:10 Thoughts on water and hydration

00:58:55 Incorporating liver and honey into your diet

1:01:15 Should we worry about uric acid on an animal-based diet?

Sponsors:

Heart & Soil: www.heartandsoil.co

White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders

Marek Health: marekhealth.com/fundamentalhealth, use code PAUL for 10% off your first lab order

Schwank Grills: schwankgrills.com, use code PAUL for $150 off a Schwank 1500 degree grill

Bon Charge: https://boncharge.com, use code CARNIVOREMD for 15% off your order

Jaksot(328)

89. The fascinating case of a mystery autoimmune illness reversed with an Animal-Based diet, with Mary Ruddick, CNC.

89. The fascinating case of a mystery autoimmune illness reversed with an Animal-Based diet, with Mary Ruddick, CNC.

Mary Ruddick is a seasoned medical nutritionist who specializes in metabolic, immune, and nervous system disorders. She is the Director of Nutrition for CaptainSoup.com, Enable Your Healing, The REIGNS Method, and the Back to Joy Program, and she currently travels the globe studying traditional diets and seeing patients online via her private practice.   Time Stamps:   0:11:16 Mary's Dream Penthouse 0:13:09 Mary on the hippo turf 0:16:13 The lion hunt (No lions were harmed in the making of this podcast) 0:20:46 How separated we've become. 0:26:39 Mary Ruddick's backstory 0:39:06 How Mary beat dysautonomia 0:47:54 What the Greeks actually eat (The blue zones are a myth) 0:54:38 Sociodemographic and Lifestyle Statistics of Oldest Old People (>80 Years) Living in Ikaria Island: The Ikaria Study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051199/ 0:55:08 Determinants of All-Cause Mortality and Incidence of Cardiovascular Disease (2009 to 2013) in Older Adults: The Ikaria Study of the Blue Zones https://journals.sagepub.com/doi/10.1177/0003319715603185?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& 0:55:41 Simplicity, purpose, and community: the recipe for a long life 1:00:07 Mary's African adventure and lots of carnivory 1:12:42 Mary eats a raw adrenal gland 1:17:09 The diet of the Shona 1:24:47 The power of traditional diets 1:28:29 Some insight into Mary's practice 1:33:12 [Vitamin K paper] 1:37:55 The role of animal foods in fertility 1:40:15 Mary's closing remarks 1:40:46 Where to find Mary Ruddick Heart & Soil: Heartandsoil.co for desiccated organ supplements  White Oak: Use “CarnivoreMD” at whiteoakpastures.com Belcampo: Use “CarnivoreMD” or “Carnivore10” at www.belcampo.com Helix: Helixsleep.com/carnivoremd for $200 off your mattress Blublox: Blublox.

25 Tammi 20211h 45min

88. Can an Animal-Based Diet reverse heart disease and diabetes? With Sean O’Mara, MD.

88. Can an Animal-Based Diet reverse heart disease and diabetes? With Sean O’Mara, MD.

Dr. O'Mara works with business executives, professional performers and athletes motivated to improve outcomes through innovative techniques of clinical enhancement. Dr. O’Mara is a partner within an innovative medical startup in Minneapolis MN called Lantu which optimizes health. Dr. O’Mara enjoys speaking with audiences about the dramatic changes within the healthcare system immediately ahead following the inevitable reversal of chronic disease and the considerable advantages which it will bring to individuals, organizations, and indeed civilization as a whole.   Time Stamps:   0:09:36 Podcast Begins 0:11:13 Visualizing visceral fat. The fat-burning power of dietary change 0:17:30 Why diet trumps exercise  0:18:41 Weight is the wrong metric  0:25:23 Will all carbs wreck your metabolic health? 0:31:24 Do vegans have visceral fat?  0:38:13 Using our senses to measure health and choose leaders  0:41:10 Premature Atherosclerosis Associated With Monogenic Insulin Resistance https://www.ahajournals.org/doi/10.1161/01.CIR.103.18.2225 0:44:45 Reversing arterial plaque with diet and lifestyle 0:55:29 Dr. Sean's personal story 1:00:14 The scoop on carbs 1:07:21 Fermented foods for gut diversity and optimal health 1:15:42 A high linoleic acid diet exacerbates metabolic responses and gut microbiota dysbiosis in obese rats with diabetes mellitus https://pubmed.ncbi.nlm.nih.gov/30672576/ 1:16:55 How microbiota affect mental health 1:18:57 Fish Oil Attenuates Omega-6 Polyunsaturated Fatty Acid-Induced Dysbiosis and Infectious Colitis but Impairs LPS Dephosphorylation Activity Causing Sepsis https://www.semanticscholar.org/paper/Fish-Oil-Attenuates-Omega-6-Polyunsaturated-Fatty-Ghosh-DeCoffe/cf8ac6686f8ccd48c215c482712430fb41826afe 1:24:15 Video Cuts Off 1:24:38 All about sprinting 1:32:27 Where to find Sean O'mara   Heart & Soil: Heartandsoil.co  Joovv: www.joovv.com/paul White Oak: Use “CarnivoreMD” at whiteoakpastures.com Belcampo: Use “CarnivoreMD” or “Carnivore10” at www.belcampo.com Sacred Hunting: www.sacredhunting.com/paul

19 Tammi 20211h 36min

Controversial Thoughts: How is an Animal-Based diet different than a Paleo diet?

Controversial Thoughts: How is an Animal-Based diet different than a Paleo diet?

Animal-based vs Keto vs Paleo Though at first glance an #Animalbased diet may look like a ketogenic or paleo diet, there are some key differences. Though a paleo diet includes meat, this type of eating forgets about the incredible nutrient richness found in organs like liver, heart, kidney, etc. A paleo diet also leaves in nuts/seeds/and leafy greens which don't really provide any unique nutrients but do lead to a lot of gas 💨, bloating, and digestive issues for many people. These are full of anti-nutrients and digestive enzyme inhibitors and are best avoided. Though a very low carbohydrate ketogenic diet can be incredibly powerful for many people with diabetes, and obesity, this way of eating isn't really sustainable long term. The fact of the matter is this, eliminating carbs can help with insulin resistance but didn't cause it in the first place. To truly treat these issues we must remove seed oils and excess linoleic acid from our diets. Once you are metabolically healthy, including carbohydrates from the least toxic plant sources (sweet/non-sweet fruit- no fructose is not toxic in fruit) can be a positive addition to your diet! Animal-based diets can take many forms to suit your needs, but don't fall into overly rigid ketogenic dogma by fearing all carbohydrates long term. Cycling in low-carb periods or periods of a carnivore diet is great, but it's also nice to bring in a few low toxicity plant foods from time to time for variety, flavor, color, etc. Just know that if you chose to include nuts/seeds/leafy greens you may run into digestive issues by trending too much toward paleo. Here's to reclaiming your birthright to radical health! #theremembering SOCIAL MEDIA Heart & Soil: https://heartandsoil.co  Instagram: https://www.instagram.com/paulsaladinomd Website: https://www.paulsaladinomd.com

15 Tammi 202118min

87. The Omega-6 Apocalypse, are seed oils to blame for diabetes, heart attacks, and chronic disease ?

87. The Omega-6 Apocalypse, are seed oils to blame for diabetes, heart attacks, and chronic disease ?

Dr. Knobbe began his practice of ophthalmology in 1994, after completing his residency training at the University of Colorado Health Sciences Center, in Denver, Colorado, USA. He was certified by the American Board of Ophthalmology in 1997 and has remained board-certified since then. Eye physician and surgeon, Chris A. Knobbe, MD, had been in practice nearly 20 years when, in 2013, he asked himself the question, “Could macular degeneration be a ‘Westernized disease’? Could AMD be a disease that is the result of a Westernized diet?” That question would forever change his life. The hypothesis that Dr. Knobbe would proffer holds that macular degeneration, which is the leading cause of irreversible vision loss and blindness in developed nations, is not only preventable but treatable in the early to moderate stages, with an ancestral diet.   Time Stamps:  0:09:24 Podcast Begins 0:12:39 200 years of nutritional research 0:23:09 Needs a title 60-sec audiogram 0:30:09 Timeline for Processed Food Introductions 0:36:44 Non-negotiable: Animal fats are essential 0:44:17 150 years of Vegetable Oil Consumption 0:49:07 Who's the real culprit? 0:51:46 Heart Disease Deaths vs Sturated fat and Vegetable Oil 1:05:32 Can linoleic acid contribute to coronary artery disease? https://www.researchgate.net/publication/15005994_Can_linoleic_acid_contribute_to_coronary_artery_disease 1:08:12 Why do we blame the carbs? 1:11:35 Sweden vs US adipose Linoleic Acid and obesity 1:14:02 The Case Of Japan 1:27:20 The problem is neither calories nor carbs 1:33:49 Is processed sugar harmful in and of itself? | What carbs to eat 1:43:36 The Case Of Okinawa 1:55:41 Diets could prevent many diseases Https://www.researchgate.net/publication/10673140_Diets_could_prevent_many_diseases 2:02:50 Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/</spa

11 Tammi 20212h 20min

Controversial Thoughts: Could coffee worsen fibromyalgia? And other reasons to avoid it on an Animal-Based diet.

Controversial Thoughts: Could coffee worsen fibromyalgia? And other reasons to avoid it on an Animal-Based diet.

What could be more controversial than suggesting that coffee might not be the elixir of life it’s cracked up to be?

8 Tammi 202134min

86. How to have the best poop of your life. Lucy Mailing PhD returns!

86. How to have the best poop of your life. Lucy Mailing PhD returns!

Lucy Mailing, Ph.D. received her Bachelor’s in Biology from Kalamazoo College and her Ph.D. in Nutritional Sciences from the University of Illinois, where her dissertation research focused on the effects of diet and exercise on the gut microbiome in states of health and disease. Lucy has authored several peer-reviewed journal articles related to the microbiome and health and was named an Emerging Leader in Nutritional Sciences by the American Society for Nutrition in 2017. Lucy has also served as a staff research associate for the Kresser Institute for Functional and Evolutionary Medicine since 2015. Lucy is the founder and sole author of lucymailing.com, a site dedicated to evidence-based articles about the microbiome, gut and skin health, and nutrition. She is regularly invited to speak on gut health around the country and has been recognized as one of the most trusted experts in the integrative health space. Lucy plans to continue her academic training and begin a postdoc in 2020 after a gap year dedicated to writing and other projects.  Time Stamps:  0:08:47 Podcast begins 0:09:55 What is a healthy gut microbiome? 0:12:43 The Microbiome of the Hadza 0:14:25 Enterocyte-Associated Microbiome of the Hadza Hunter-Gatherers https://www.frontiersin.org/articles/10.3389/fmicb.2016.00865/full 0:18:36 Figure: Typical major phyla and genera of the human gut microbiome https://www.researchgate.net/figure/Typical-major-phyla-and-genera-of-the-human-gut-microbiome-reproduced-with-permission_fig1_331990159 0:22:05 Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania https://science.sciencemag.org/content/357/6353/802#:~:text=The%20data%20reveal%20annual%20cyclic,reappear%20in%20a%20subsequent%20season.&text=These%20data%20indicate%20that%20some,and%20abundance%20in%20modernized%20populations. 0:24:38 Pervasive bias in research 0:30:10 Gut microbiome of the Hadza hunter-gatherers https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996546/ 0:31:11 Microbiological dark matter and the infancy of gut microbiology 0:38:17 The Story of Butyrate 0:42:19 Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepati

4 Tammi 20212h 14min

Controversial thoughts: Which alcohol is the least toxic? And how to fix a hangover!

Controversial thoughts: Which alcohol is the least toxic? And how to fix a hangover!

Happy New Year to all!  I’m not a drinker, but I know there are many who will be enjoying alcohol to celebrate the end of this crazy year, and the beginning of one we all hope will be a bit better than 2020. If you’re going to imbibe at New Years or any other time, what’s the least toxic sauce to consume? Find out in this Controversial Thoughts video along with why alcohol causes a hangover and what you can do to mitigate it prior and ameliorate it once it’s besieged you. Hint:  these answers may have to do with things I’ve discussed before like avoiding toxic seed oils to limit lipid peroxidation in your liver from alcohol byproducts, and making sure to get enough nutrients into your diet on a daily basis to optimize your glutathione and NAD/NADH statuses.  If you’re looking to lose weight, or kick more ass in 2021 you should join us at Heart & Soil for our 30 day animal based reset in January. Go to www.AnimalBased30.com to sign up and become part of the tribe that will be starting off the new year right! There will be lots of content, support, and a chance to win some of our desiccated organ supplements as well as signed copies of my book, The Carnivore Code. Welcome to #theremembering.

30 Joulu 202026min

85. How to make your immune system strong as heck, Part 2 with James DiNicolantionio, Pharm D

85. How to make your immune system strong as heck, Part 2 with James DiNicolantionio, Pharm D

Find part 1 of this podcast with James, here.    Dr. James DiNicolantonio, is a Doctor of Pharmacy and a cardiovascular research scientist. A well-respected and internationally known scientist and an expert on health and nutrition, he has contributed extensively to health policy and has testified in front of the Canadian Senate regarding the harms of added sugars. He serves as the associate editor of the British Medical Journal’s Open Heart, a journal published in partnership with the British Cardiovascular Society, and is on the editorial advisory boards of several other medical journals. Dr. DiNicolantonio is the author or coauthor of over 250 publications in the medical literature. He also is the author of three bestselling health books, The Salt Fix, Superfuel and The Longevity Solution, as well as his newest book, The Immunity fix which you can find here. You can follow him on Instagram and Twitter @drjamesdinic and on Facebook at Dr. James DiNicolantonio. You can visit his website at drjamesdinic.com. Time stamps:    0:08:11 Podcast begins  0:09:16 How to create metabolic health  0:16:54 A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(98)90067-9  0:19:55 Omega six fatty acids and oxidative stress  0:21:07 Premature atherosclerosis associated with monogenic insulin resistance https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&  0:22:00 Elevated Serum C-Reactive Protein and Free Fatty Acids Among Nondiabetic Carriers of Missense Mutations in the Gene Encoding Lamin A/C (LMNA) With Partial Lipodystrophyhttps://www.ahajournals.org/doi/10.1161/01.atv.0000047460.27435.b8?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed  0:32:46 Answering the fructose question and dispelling keto dogma  0:40:17 What nutrients are required for robust immunity  0:40:17 Is colostrum more effective than vaccines?  0:41:56 Prevention of Influenza Episodes With Colostrum Compared With Vaccination in Healthy and High-Risk Cardiovascular Subjects: The Epidemiologic Study in San Valentino<a href= "https://journals.sagepub.com/doi/10.1177/1076029606295957?url_ver=Z39.88-2003&rfr_id=ori%

28 Joulu 20201h 4min

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