#360: How Liz Parrish Is REWRITING the Rules of Aging (Gene Therapy, Telomeres & The Future of Longevity)

Have you ever sifted through a mountain of health advice only to feel more lost than when you started?    That's where Dr. Elizabeth Yurth comes in—guiding us through aging research with her knowledgeable insights. In today’s episode, we discuss anti-aging medicine, the pitfalls of research bias, and the gender discrepancies that muddy the waters of scientific studies.  With a nod to John Ioannidis' work, we talk about the need for validating scientific claims. When theory meets practice, the truth can be surprising. We share firsthand experiences from clinical work, revealing how animal studies fare once they reach the human testing ground.    Overall, we explore the heart of longevity, where social connections and stress-free living are crucial.    Dr. Elizabeth Yurth is the Co-Founder and Chief Medical Officer of Boulder Longevity Institute, where she has been providing Tomorrow’s Medicine Today to her clients since 2006. Dr. Yurth has completed over 500 hours of Continuing Medical Education (CME) training in the areas of Longevity, Epigenetics, Nutrition, Bioidentical Hormone Replacement Therapy, Regenerative Peptide Treatments, and Regenerative Orthopedic Procedures.  Thank you to our sponsors for making this episode possible: Quicksilver: Visit quicksilverscientific.com/nat and use code Nat for 10% off your first purchase of PushCatch® Liver Detox. BiOptimizers: For Sleep Breakthrough use code bionat at checkout to save on your order at bioptimizers.com/bionat   Find more from Dr. Elizabeth Yurth:  Website: https://boulderlongevity.com/  Instagram: @boulderlongevityinstitute Youtube: https://www.youtube.com/@boulderlongevityinstitutel5018    Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Join Nat’s Membership Community: https://www.natniddam.com/bsp-community  Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0  Instagram: https://www.instagram.com/nathalieniddam/  Website: www.NatNiddam.com    Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance  What We Discuss:  (00:02) Navigating Aging Research and Recommendations (07:22) Clinical Testing Ground for Longevity Drugs (20:05) Benefits and Risks of Antioxidants (31:42) Cycling Supplements and Aging Measurements (35:47) Reevaluating Biological Aging and Longevity (45:03) Low-Dose Naltrexone for Repurposed Medication (54:56) Drug Repurposing for Various Health Conditions (01:00:33) Weight Loss Drugs and Their Effects (01:11:24) Cellular Health and Longevity Discussion Key Takeaways: Research findings should be critically evaluated, considering factors such as study design, reproducibility, and applicability to humans. LDN can be effective in reducing cramps and arthritis symptoms by deactivating microglial cells. Amlexanox is an underutilized drug with anti-allergic and anti-inflammatory properties. Tessafensin, a triple uptake inhibitor, may aid in weight loss and improve cellular function.

11 Kesä 20241h 26min

When you think of creatine, what comes to mind? If you're like most people, you probably associate it with building muscle and enhancing athletic performance. But did you know that creatine has benefits that go far beyond the gym?   In today's podcast episode, I dive into the fascinating world of creatine and discuss its incredible potential for supporting brain health, bone density, and even protecting your DNA from damage. That's right – creatine isn't just for athletes anymore!   To get the full scoop on how this simple compound can help you optimize your health and potentially slow down the aging process, I encourage you to tune in. In just 30 minutes, you'll gain a wealth of knowledge about creatine and how to incorporate it into your daily routine for maximum benefits. Thank you to our sponsors for making this episode possible: LVLUP: Use code NAT10 to save 10% off at https://lvluphealth.com/   Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0 Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance   What I discuss: 2:24 How to supplement with creatine  4:47 How creatine works in the mitochondria   7:11 Creatine's benefits for muscle, including satellite cell activation and heat tolerance  9:34 Creatine's benefits for bone health and remodeling   11:59 Creatine's neuroprotective effects and cognitive benefits, especially for older adults   14:25 Creatine's potential benefits for depression, diabetes, and cardiac insufficiency   16:24 Creatine's role in protecting mitochondrial DNA from damage   21:00 Concerns about creatine supplementation, including kidney health, hair loss, and cancer  25:43 Recommendations for creatine supplements and how to incorporate them into your routine   Key Takeaways: Creatine has wide-ranging benefits beyond athletic performance, including muscle, bone, brain, DNA protection, diabetes, heart health, and skin. Supplementation guidelines for creatine include dosing, timing, and potential concerns for kidney health, hair loss, and cancer. Creatine may have positive effects on various health conditions, but individuals should consult with their healthcare provider before starting supplementation.

7 Kesä 202433min

Are you tired of yo-yo dieting and struggling to achieve lasting weight loss? Have you heard about the buzz surrounding GLP-1 agonist medications like semaglutide and tirzepatide but aren't sure how to effectively incorporate them into your journey?    In today’s episode, Dr. Gus Vickery and I discuss the effective use of GLP-1 agonist medications like semaglutide and tirzepatide for sustainable weight loss. He emphasizes the need for a mindset shift, viewing these drugs as powerful tools to catalyze positive changes rather than easy fixes or crutches. Dr. Vickery explains that these medications provide leverage to implement foundational healthy habits and that the key to success lies in focusing on nutrient sufficiency, not just calorie restriction.   We also discuss concerns surrounding GLP-1 medications, such as the potential for muscle loss and the risk of regaining weight after discontinuing the drugs. He shares strategies to mitigate these issues, including resistance training, adequate protein intake, and gradual dose reduction when nearing one's goal weight.   Dr. Gus Vickery is an author, speaker, and the founder and directing physician of Authentic Health in Asheville, North Carolina. He established his practice with a commitment to delivering holistic, compassionate, and evidence-based care.   Thank you to our sponsors for making this episode possible: Quicksilver: Visit quicksilverscientific.com/nat and use code Nat for 10% off your first purchase of PushCatch® Liver Detox. Neurohacker Collective: Visit neurohacker.com/nathalie and use code NATHALIE Inside Tracker: Use NIDDAM to save 10% at https://www.insidetracker.com   Find more from Dr. Gus Vickery:  Website: https://drgusvickery.com/  Authentic Health Book: https://drgusvickery.com/book/  Instagram: @drgusvickerymd  Youtube: The Family Doctor Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Join Nat’s Membership Community: https://www.natniddam.com/bsp-community  Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0  Instagram: https://www.instagram.com/nathalieniddam/  Website: www.NatNiddam.com    Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance  What We Discuss:  04:00 Understanding the Power of Peptides 07:45 The Underlying Benefits of Peptides 12:59 Addressing Concerns about Side Effects 29:06 The Right Way to Use Peptides 30:06 Hormone Therapy and Peptides 34:12 Nutrient Sufficiency and Protein 41:17 The Impact of Fasting and Gut Health 45:33 Addressing Microbiome Balance 58:56 The Pace of Fat Loss and Patience 59:42 Pushing Through Plateaus and Delicate Nervous System 01:07:13 Managing Hormetic Stress and Resting the Nervous System 01:09:00 Choosing Carbs or Fats and Individualization   Key Takeaways: Peptides can be a powerful tool for improving body composition and metabolic health. It is important to understand the proper use of peptides and not rely on them as a quick fix or easy way out. Peptides have a range of benefits, including improving insulin sensitivity and reducing fatty liver disease. Concerns about side effects and risks should be weighed against the potential benefits and individual circumstances

4 Kesä 20241h 28min

Have you ever wondered why some people seem to bounce back from stress more easily than others? The answer may lie in the strength of their vagus nerve.   In today’s episode of the Longevity Podcast, I chat with Dr. Navaz Habib about the importance of the vagus nerve and its impact on heart rate variability (HRV). He explains that the vagus nerve is a unique nerve that connects the brain to all organs in the thorax and abdomen, allowing for communication and signaling. Vagal tone, which refers to the strength of the signals sent through the vagus nerve, is crucial for optimal health.    Dr. Habib identifies four types of stressors that can affect vagal tone: emotional, physical, biochemical, and psychological. He emphasizes the importance of proper breathing techniques, such as slow, diaphragmatic breathing, to improve vagal tone. We also discuss the role of nitric oxide in supporting vagus nerve function and how to supplement it for overall health.    Dr. Navaz Habib, is a Doctor of Chiropractic and Functional Medicine Practitioner who empowers his clients to dig deeper and find the answers to what is holding back their health, affecting their energy and productivity. He is also the host of The Health Upgrade Podcast and speaks on various topics related to Vagus Nerve and its impact on optimal health.   Thank you to our sponsors for making this episode possible: Fatty15: Visit http://fatty15.com/NAT  and use promo code NAT to save. Mitopure: Use code NAT10 for 10% your order at https://www.timelinenutrition.com/shop/nutrition  Berkeley Life: Consumers may register and place an order using my code NIDDBL for 10% off at berkeleylife.com    Find more from Dr. Navaz Habib: Website: https://drnavazhabib.kartra.com/page/DrHabibHome  Instagram: @drnavazhabib Book: Upgrade Your Vagas Nerve Podcast: The Health Upgrade Podcast   Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Join Nat’s Membership Community: https://www.natniddam.com/bsp-community  Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0  Instagram: https://www.instagram.com/nathalieniddam/  Website: www.NatNiddam.com    Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance  What We Discuss:  00:00 Introduction and Importance of the Vagus Nerve 15:21 Understanding Vagal Tone and Its Importance 28:42 Heart Rate Variability and Its Significance 31:27 Using HRV as a Future-Focused Tool 36:02 The Connection Between Nitric Oxide and the Vagus Nerve 45:45 Breathwork and Dietary Support for Vagal Tone 51:07 Electrical Vagus Nerve Stimulation for Vagal Function   Key Takeaways: The vagus nerve is a unique nerve that connects the brain to all organs in the thorax and abdomen, allowing for communication and signaling. To improve vagal tone and support the vagus nerve, practice breathwork techniques such as diaphragmatic breathing and longer exhales. Consider nitric oxide supplementation and maintain electrolyte balance to enhance vagal tone.

31 Touko 20241h 7min

Do you want to optimize fat loss, hormone health, and/or bone strength? You should know that muscle is your secret weapon.    In today’s episode of the Longevity Podcast, I talk with Eric Fete, DO about the intricate relationship between muscle and bone health, and how strength training, proper nutrition, and supplements can help maintain and improve both. We also explore the importance of muscle as a powerful energy factory due to its high concentration of mitochondria, and how staying active can help reclaim your energy levels. Dr Eric and I touch on the crucial role of testosterone in women's health, and how lifting heavy can support this hormone, leading to improved insulin sensitivity, muscle mass, blood pressure, mood, and a reduced risk of cancer.   Lastly, we address concerns about fat loss peptides potentially causing muscle mass loss. We emphasize that proper nutrition and strength training can help negate these effects, ensuring that weight loss comes primarily from body fat.    Dr. Eric Fete, DO is the founder of PrimeX, a preventive health, age management, and peak performance company that provides nutrition products, educational materials, physician-grade supplements, hormone therapy, and personalized health plans for maximum health, vitality, performance, and wellness.    Thank you to our sponsors for making this episode possible: Mitopure: Use code NAT10 for 10% your order at https://www.timelinenutrition.com/shop/nutrition Quicksilver: Visit quicksilverscientific.com/nat and use code Nat for 10% off your first purchase of PushCatch® Liver Detox. BiOptimizers: For Sleep Breakthrough use code bionat at checkout to save on your order at bioptimizers.com/bionat Find more from Eric Fete, DO: Website: www.drericprimex.com, www.primexweightloss.com Instagram: https://www.instagram.com/drericfete/  Youtube: https://www.youtube.com/@dr.eric-primexthefitnessph6601  Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Join Nat’s Membership Community: https://www.natniddam.com/bsp-community  Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0  Instagram: https://www.instagram.com/nathalieniddam/  Website: www.NatNiddam.com    Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance  What We Discuss:  1:30 Muscle Medicine vs Sick Medicine with Eric Fete, DO 7:30 The relationship between muscle and bone 12:50 Vibration plates  25:00 How muscle affects metabolism 31:00 Testosterone for women and estrogen for men 42:50 GLP-1s and building muscle  54:55 Supplements for people who don’t want GLP-1s   Key Takeaways: Muscles secret myokines which directly build bone and make it stronger. Myokines exert a stimulative effect and prevent bone reabsorption (breaking down and weakening). Proper nutrition, strength training, and supplements can mitigate bone deterioration. Muscle is one of the most powerful energy factories because it’s full of mitochondria. You can reclaim your energy by being active.  Fat loss peptides can possibly make you lose muscle mass, but proper nutrition and strength training can negate those effects so you lose mainly body fat. You could also balance it out by using other peptides like growth hormone.

28 Touko 20241h 12min

How can our mindset, emotions, and life experiences impact our physical health and immune function in ways that are often overlooked by conventional medicine?   We’re diving right into this topic for today’s conversation. Dr. Olivia Lesslar joins the podcast to discuss the field of psycho neuro immunology (PNI) and its impact on health and well-being. She explains the complexity of PNI and how everything in the body is interconnected. Dr. Lesslar emphasizes the power of belief and mindset in influencing health outcomes and highlights the importance of addressing emotions and attitudes in patient care.    We also discuss the role of compassion in medicine and the need to treat the whole person. Our conversation explores the subjectivity of pain, the impact of hypochondria and the nocebo effect, and the potential for small changes to make a significant difference in health.    Dr Olivia works with innovative clinics and organizations worldwide. Her coordinating clinic is Cingulum Health - a neuro center founded by renowned neurosurgeon Professor Charles Teo.   She is an Adjunct Senior Lecturer with The National Centre for Neuroimmunology and Emerging Diseases.   Thank you to our sponsors for making this episode possible: Neurohacker Collective: Visit neurohacker.com/nathalie and use code NATHALIE Fatty15: Visit http://fatty15.com/NAT and use promo code NAT to save. Inside Tracker: Use NIDDAM to save 10% at https://www.insidetracker.com   Find more from Olivia Lesslar: Website: https://www.drolivialesslar.com/  Instagram: https://www.instagram.com/drolivialesslar/  Facebook: https://www.facebook.com/drolivialesslar  Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Join Nat’s Membership Community: https://www.natniddam.com/bsp-community  Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0  Instagram: https://www.instagram.com/nathalieniddam/  Website: www.NatNiddam.com    Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance  What We Discuss:  02:13 Psycho Neuro Immunology (PNI) 03:35 The Complexity of PNI 06:16 The Power of Belief and Mindset 10:47 Anxiety and the Importance of Letting Go 17:15 Navigating Hypochondria and Nocebo Effect 20:50 The Power of Small Changes 26:09 The Role of Transient Receptor Potential Ion Channels 39:02 Immunotherapy and Emotions 40:20 The Impact of Stress on Allergies 41:57 The Neglect of Lifestyle Changes in Medicine 50:42 Curiosity and Open-Mindedness in Medicine 53:23 Reframing Threats and Flooding the Body with Safety Signals 01:02:43 The Biology of Belief and Curiosity Key Takeaways: Psycho neuro immunology (PNI) is a field that explores the interconnectedness of psychology, the nervous system, the immune system, and hormones. Belief and mindset have a significant impact on health outcomes and can influence the body's physiological responses. Emotions and attitudes play a crucial role in overall well-being and should be addressed in patient care.

21 Touko 20241h 14min

Ever find yourself tossing and turning in a hotel bed, wondering why the magic of sleep eludes you just when you need it the most?   Join me in this round table episode to unravel the secrets of sleep and its profound effects on our well-being, particularly as we age. I join Kristen Weitzel and The Biohacker Babes - Lauren and Renee- to uncover the delicate dance between nurturing our social lives and honoring the rejuvenation sleep offers.   Imagine managing your slumber in the tight confines of van life or the unfamiliar settings of a hotel room—how do you find your sleep rhythm there? We share our trials and triumphs as we strive for sleep efficiency, discuss the fascinating bio-individuality of sleep supplements, and offer an array of strategies to combat the stress that comes with non-traditional living arrangements. We provide insights into personalizing your approach to rest, regardless of where life takes you.   Lastly, we delve into sleep sanctuaries, the power of darkened rooms (we talk about a great new entry in the blackout shades space - UBLOCKOUT Shades), cooling mattresses, and the innovative Moonbird device for better breathing. We also celebrate the potential of CGM devices to enhance our understanding of sleep's relationship with our diets and habits. So, pull up a chair (or a pillow) and join us for a discussion brimming with anecdotes, tips, and biohacks that promise to help guide you into the best sleep!    To try UBLOCKOUT Shades use code NAT10 (save 10%) and shop here.    Thank you to our sponsors for making this episode possible: LVLUP: Use code NAT10 to save 10% off at https://lvluphealth.com/   Find more from Lauren Sambataro and Renee Belz:  Instagram: @biohacker_babes  Website: https://thebiohackerbabes.com/ Podcast: Biohacker Babes   Find more from Kristin Weitzel:  Instagram: @wellpowerpodcast  Website: https://www.wellpower.life/  Podcast: WELLPOWER   Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0 Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance   What We discuss: (00:00) Challenges and Strategies for Sleep (06:50) Managing Sleep in Unconventional Living (16:43) Optimizing Sleep Quality and Environment (27:36) Importance of Sleep Environment Factors (38:01) Investing in Quality Sleep Solutions (44:42) Supplement Mislabeling and Melatonin Usage (56:13) Exploring Health Trends and Habits (01:06:15) Sleep and Wellness Hacks and Tips (01:15:37) Biohacking and Wellness Podcast Collaboration Key Takeaways: There are many lifestyle factors and tools that can impact sleep quality, including light exposure, temperature, sound, supplementation, rituals, and more. It's important to experiment and find what works best for you as an individual. Blocking out light in the bedroom is crucial for good sleep. Strategies include using blackout shades, sleep masks, and covering any LED lights. Getting natural bright light exposure, especially in the morning, helps regulate circadian rhythms.

17 Touko 20241h 24min

Are you considering facial rejuvenation for aesthetic reasons? Or do you want to use Botox or filler for anti-aging purposes? Today’s episode gives you the ins and outs of facial aesthetics and how to approach them with longevity in mind.    Today on the Biohacking Superhuman Performance Podcast, I talk with Dr. Cameron Chesnut, a facial plastic surgeon, about his approach to facial rejuvenation and aesthetics. He emphasizes the importance of artistry and individualized treatment in his practice. Dr. Chesnut also addresses the use of Botox and fillers, highlighting the narrow lane in which they should be applied and the potential risks of overuse. We discuss the advancements in minimally invasive techniques that reduce trauma and improve outcomes. Dr. Chesnut advises individuals to seek reputable practitioners and consider long-term goals when considering facial procedures. In this conversation, Dr. Cameron Chesnut and I discuss various aspects of cosmetic procedures and their impact on longevity and overall well-being. He emphasizes the importance of exploring the spectrum of available procedures and understanding the baseline tissue quality for long-lasting results.    Overall, Dr. Chesnut highlights the role of hormone replacement therapy in enhancing the outcomes of procedures and the significance of personalized preoperative protocols. He shares his approach to managing discomfort without the use of painkillers and the importance of realistic expectations and patient education.   Dr. Chesnut is the facial plastic surgeon for the world’s high-performers. People from all corners of the globe seek his next-level results - with astonishing outcomes from minimally invasive procedures that leave his patients looking natural, rejuvenated, and seemingly untouched. He is renowned for his progressive use of regenerative medicine and postoperative recovery techniques, as well as his dedicated personal preparation for performance readiness. Even Dr. Chesnut’s anesthesia protocol is next level - focused on protecting your neurocognitive function with the safest, opioid-free anesthesia. This is NOT general anesthesia, and it even allows Dr. Chesnut to help optimize the sleep cycle after surgery.   Thank you to our sponsors for making this episode possible: Berkeley Life: Consumers may register and place an order using my code NIDDBL for 10% off at berkeleylife.com Vitali: Visit: https://www.vitaliskincare.com and use code NAT25 to save on your order. BiOptimizers: For Sleep Breakthrough use code bionat at checkout to save on your order at bioptimizers.com/bionat Find more from Dr. Cameron Chesnut: Website: https://www.clinic5c.com/about/dr-cameron-chesnut/  Instagram: @chesnut.md https://www.instagram.com/clinic5c.functionalmed/    Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Join Nat’s Membership Community: https://www.natniddam.com/bsp-community  Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0  Instagram: https://www.instagram.com/nathalieniddam/  Website: www.NatNiddam.com    Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance    What We Discuss:  03:02 The Art of Facial Plastic Surgery 07:52 Approach to Medicine and Wellness 12:28 Facial Rejuvenation and Aesthetics 18:13 The Narrow Lane of Botox and Fillers 23:00 Minimally Invasive Techniques and Trauma 26:40 Best Practices for Botox and Fillers 32:44 Preparing for Future Procedures 34:24 Exploring the Spectrum of Procedures 35:10 Baseline Tissue Quality and Longevity of Results 36:23 Recovery in a Functional Medicine Setting 37:40 Hormone Replacement and Procedure Duration 38:25 Customizing Procedures Based on Hormone Status 39:32 Determining When a New Procedure is Needed 40:07 Rejuvenation vs. Transformation in Older Patients 41:30 Treating the Entire Face for Natural Results 41:44 Preoperative Protocol and Individualized Care 44:11 Utilizing Peptides for Preoperative Preparation 46:37 Ideal Patients and the Screening Process 51:24 Managing Discomfort and Pain Medication 54:37 The Impact of Facial Appearance on Health and Communication 58:33 Educating Patients and Realistic Expectations Key Takeaways: Facial plastic surgery requires an artistic approach and individualized treatment. Botox and fillers have a narrow lane of application and should be used judiciously. Advancements in minimally invasive techniques have reduced trauma and improved outcomes. It is important to seek reputable practitioners and consider long-term goals when considering facial procedures. Exploring the spectrum of available procedures can help individuals make informed decisions about their cosmetic goals. Baseline tissue quality and hormone status play a significant role in the longevity of procedure results. Personalized preoperative protocols, including hormone replacement therapy, can enhance the outcomes of procedures. Managing discomfort without painkillers and setting realistic expectations are crucial for a successful recovery and long-term satisfaction.

14 Touko 20241h 17min