#105 - Delta Sleep Inducing Peptides

#105 - Delta Sleep Inducing Peptides

In this episode, Matt delves into the curious and cautionary tale of Delta Sleep-Inducing Peptide (DSIP), once hailed as a potential miracle cure for insomnia. In the 1970s, researchers were on a quest for a single "somnogenic molecule" that could act as the brain's natural sleep switch. A Swiss team believed they had found it, isolating a peptide that appeared to rapidly induce deep, slow-wave sleep when injected into animals. This initial excitement led to bold claims and sparked decades of...

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Jaksot(185)

#148 - Psychedelics for Mental Health

#148 - Psychedelics for Mental Health

Matt delves into how psychedelics like psilocybin and LSD quiet the "Default Mode Network" to boost neuroplasticity. He describes these molecules as a "crowbar" that allows therapy to break deep-seate...

17 Elo 32min

#147 - Does Sleep Really Clean Your Brain?

#147 - Does Sleep Really Clean Your Brain?

Matt explores the brain's secret plumbing, a waste-clearance network once ignored for over a century. He explains how the glymphatic system flushes metabolic toxins like amyloid-beta during sleep. Thi...

10 Elo 25min

#146 - How Sleep Changes Across the Human Lifespan

#146 - How Sleep Changes Across the Human Lifespan

Matt tracks sleep across the human lifespan, from newborn "active sleep" to the shifts of healthy aging. He explores how biological milestones - like puberty, pregnancy, and menopause - impact rest, r...

3 Elo 20min

#145 - How to get More Deep Sleep

#145 - How to get More Deep Sleep

Matt explains the science of deep sleep, emphasizing that this front-loaded stage is vital for physical and mental repair. To boost it, he recommends "builders" like consistent wake times, daily exerc...

27 Heinä 32min

#144 - Face Blindness Explained

#144 - Face Blindness Explained

Matt explores how the brain constructs reality by examining neurological anomalies. He contrasts "super-recognizers" with those living with prosopagnosia, or face blindness. By analyzing the Capgras d...

20 Heinä 28min

#143 - The Science of Love, Desire, and Sex

#143 - The Science of Love, Desire, and Sex

Matt examines the neurobiology of love, defining it as a reward system rather than just an emotion. He breaks love into three systems: lust (hormones), attraction (dopamine), and attachment (oxytocin)...

13 Heinä 33min

#142 - How Memory Affects Sleep

#142 - How Memory Affects Sleep

Exploring how daily memories shape the biology of sleep, Matt reveals that, beyond consolidating facts, the brain's restorative depth is a response to daytime effort. By showing how learning deepens s...

6 Heinä 29min

The Beekeepers Garden -  A Sleep Story Read by Matt Walker

The Beekeepers Garden - A Sleep Story Read by Matt Walker

Matt invites you to embark upon a gentle journey to a peaceful, restful sleep. After settling in and breathing deeply, you will find yourself on a winding lane. Matt guides you past a mossy stone wal...

29 Kesä 25min

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