#118 - Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging
The Peter Attia Drive6 Heinä 2020

#118 - Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging

Lloyd Klickstein is the Chief Science Officer at resTORbio, a biopharmaceutical company that develops medications to target the biology of aging. In this episode, Lloyd discusses his company's clinical application of rapamycin and its derivatives. He also elucidates details of his 2014 paper—a paper that greatly influenced Peter's perspective of rapamycin in the context of longevity. Peter and Lloyd go on to discuss the dose-dependent effect of rapamycin on immune function and compare rapamycin, fasting, and caloric restriction. We discuss:
  • His background and decision to leave academia for translational medicine [6:15];
  • Translational medicine—bridging the gap between basic science and clinical medicine [10:30];
  • What prompted Lloyd to focus on mTOR inhibition? [18:00];
  • Defining mTOR, TORC1, and TORC2, and the consequences of inhibiting them with rapamycin [21:30];
  • Dose-dependent impact of rapamycin on immune function, mTOR inhibition, and toxicity [42:15];
  • Lloyd's 2014 experiment—mTOR inhibition improves immune function in the elderly [53:00];
  • Insights into autophagy, antigen presentation, and the pleiotropic benefits of a rapalog, and how it compares to fasting [1:13:00];
  • Lloyd's 2018 experiment—TORC1 inhibition enhances immune function and reduces infections in the elderly [1:18:45];
  • Creation of resTORbio, subsequent studies, and takeaways about dosing, TORC2 inhibition, and tissue selectivity [1:29:00];
  • Comparing the longevity effect of rapamycin, fasting, and caloric restriction [1:40:00];
  • Excitement around RTB101—resTORbio's mTOR inhibiting molecule [1:47:00];
  • Identifying rapalogs selective for TORC1 [1:56:15];
  • Treating depression with ketamine, an activator of mTOR [2:00:00];
  • Epigenetic clocks, rapalogs, and metformin [2:03:30]; and
  • More.

Learn more: https://peterattiamd.com/

Show notes page for this episode: https://peterattiamd.com/LloydKlickstein

Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/

Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/

Connect with Peter on Facebook | Twitter | Instagram.

Jaksot(435)

#371 – Women's sexual health: desire, arousal, and orgasms, navigating perimenopause, and enhancing satisfaction | Sally Greenwald, M.D., M.P.H.

#371 – Women's sexual health: desire, arousal, and orgasms, navigating perimenopause, and enhancing satisfaction | Sally Greenwald, M.D., M.P.H.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Sally Greenwald is an OB-GYN who specializes in women's sexual hea...

3 Marras 20251h 52min

Longevity 101: a foundational guide to Peter's frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more (re-broadcast)

Longevity 101: a foundational guide to Peter's frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more (re-broadcast)

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode, Peter provides a comprehensive introducti...

27 Loka 20251h 25min

#370 - AMA #76: Peter evaluates longevity drugs, aspirin for CVD, and strategies to improve muscle mass — proven, promising, fuzzy, noise, or nonsense?

#370 - AMA #76: Peter evaluates longevity drugs, aspirin for CVD, and strategies to improve muscle mass — proven, promising, fuzzy, noise, or nonsense?

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter revisits the "prove...

27 Loka 202517min

#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.

#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Rhonda Patrick is a scientist, health educator, and host of the Fo...

20 Loka 20251h 50min

#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.

#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter David Allison is a world-renowned scientist and award-winning scie...

13 Loka 20251h 49min

#367 - Tylenol, pregnancy, and autism: What recent studies show and how to interpret the data

#367 - Tylenol, pregnancy, and autism: What recent studies show and how to interpret the data

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode of The Drive, Peter addresses the recent h...

6 Loka 20251h 27min

#366 ‒ Transforming education with AI and an individualized, mastery-based education model | Joe Liemandt

#366 ‒ Transforming education with AI and an individualized, mastery-based education model | Joe Liemandt

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Joe Liemandt is a software entrepreneur turned education reformer ...

29 Syys 20251h 47min

#365 ‒ Training for longevity: A roundtable on building strength, preventing injury, meeting protein needs, guidance for women and youth athletes, and more | Gabrielle Lyon, Mike Boyle, Jeff Cavaliere

#365 ‒ Training for longevity: A roundtable on building strength, preventing injury, meeting protein needs, guidance for women and youth athletes, and more | Gabrielle Lyon, Mike Boyle, Jeff Cavaliere

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode of The Drive, Peter hosts a strength and c...

22 Syys 20252h 15min

Suosittua kategoriassa Terveys ja hyvinvointi

unicast
voi-hyvin-meditaatiot-2
vakeva-elama-viisaampi-mieli-vahvempi-keho
tiedenaiset-podcast
psykopodiaa-podcast
rss-pitaisko-erota
puhu-muru
katilon-kahvitunti
terapiassa
rss-uplevel-by-sonja-hannus
rss-rakas-mielenterveyteni
rss-narsisti
selviytyjat-tarinoita-elamasta
junnut-pelissa
rss-duodecim-lehti
meditaatiot-suomeksi
audio-sport-juoksu
rss-pt-paahtio
rss-addiktit
rss-vapaudu-voimaasi