#140 - Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications
The Peter Attia Drive7 Joulu 2020

#140 - Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications

Gerald Shulman is a Professor of Medicine, Cellular & Molecular Physiology, and the Director of the Diabetes Research Center at Yale. His pioneering work on the use of advanced technologies to analyze metabolic flux within cells has greatly contributed to the understanding of insulin resistance and type 2 diabetes. In this episode, Gerald clarifies what insulin resistance means as it relates to the muscle and the liver, and the evolutionary reason for its existence. He goes into depth on mechanisms that lead to and resolve insulin resistance, like the role of diet, exercise, and pharmacological agents. As a bonus, Gerald concludes with insights into Metformin's mechanism of action and its suitability as a longevity agent.

We discuss:

  • Gerald's background and interest in metabolism and insulin resistance (4:30);
  • Insulin resistance as a root cause of chronic disease (8:30);
  • How Gerald uses NMR to see inside cells (12:00);
  • Defining and diagnosing insulin resistance and type 2 diabetes (19:15);
  • The role of lipids in insulin resistance (31:15);
  • Confirmation of glucose transport as the root problem in lipid-induced insulin resistance (40:15);
  • The role of exercise in protecting against insulin resistance and fatty liver (50:00);
  • Insulin resistance in the liver (1:07:00);
  • The evolutionary explanation for insulin resistance—an important tool for surviving starvation (1:17:15);
  • The critical role of gluconeogenesis, and how it's regulated by insulin (1:22:30);
  • Inflammation and body fat as contributing factors to insulin resistance (1:32:15);
  • Treatment approaches for fatty liver and insulin resistance, and an exciting new pharmacological approach (1:41:15);
  • Metformin's mechanism of action and its suitability as a longevity agent (1:58:15);
  • More.

Learn more: https://peterattiamd.com/

Show notes page for this episode: https://peterattiamd.com/geraldshulman

Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/

Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/

Connect with Peter on Facebook | Twitter | Instagram.

Jaksot(433)

#386 - Aging clocks—what they measure, how they work, and their clinical and real-world relevance

#386 - Aging clocks—what they measure, how they work, and their clinical and real-world relevance

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this episode, Peter takes a deep dive into the science and appl...

6 Huhti 55min

#385 - AMA #82: Applying the tools of longevity in the real world: disease prevention, DEXA scans, artificial sweeteners, injury recovery, stability training, habit formation, protein intake and mTOR activation, and more

#385 - AMA #82: Applying the tools of longevity in the real world: disease prevention, DEXA scans, artificial sweeteners, injury recovery, stability training, habit formation, protein intake and mTOR activation, and more

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter answers listener qu...

23 Maalis 18min

#384 - Special episode — Obicetrapib: The CETP inhibitor with cardiovascular benefits and potential Alzheimer's prevention

#384 - Special episode — Obicetrapib: The CETP inhibitor with cardiovascular benefits and potential Alzheimer's prevention

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode, Peter takes a deep dive into obicetrapib,...

16 Maalis 52min

#380 ‒ The seed oil debate: are they uniquely harmful relative to other dietary fats? | Layne Norton, Ph.D.

#380 ‒ The seed oil debate: are they uniquely harmful relative to other dietary fats? | Layne Norton, Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Layne Norton is a nutrition scientist and accomplished power athle...

19 Tammi 2h 7min

#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence

#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter brings together his...

12 Tammi 38min

#378 ‒ Women's health and performance: how training, nutrition, and hormones interact across life stages | Abbie Smith-Ryan, Ph.D.

#378 ‒ Women's health and performance: how training, nutrition, and hormones interact across life stages | Abbie Smith-Ryan, Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Abbie Smith-Ryan is a leading researcher in exercise physiology wh...

5 Tammi 2h 11min

Building & Changing Habits | James Clear (#183 rebroadcast)

Building & Changing Habits | James Clear (#183 rebroadcast)

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter James Clear is the author of the New York Times bestseller Atomic ...

29 Joulu 20252h 19min

#377 ‒ Special episode: Understanding true happiness and the tools to cultivate a meaningful life—insights from past interviews with Arthur Brooks

#377 ‒ Special episode: Understanding true happiness and the tools to cultivate a meaningful life—insights from past interviews with Arthur Brooks

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode of The Drive, Peter presents a curated "be...

22 Joulu 20251h 39min

Suosittua kategoriassa Terveys ja hyvinvointi

unicast
tiedenaiset-podcast
psykopodiaa-podcast
voi-hyvin-meditaatiot-2
rss-pitaisko-erota
vakeva-elama-viisaampi-mieli-vahvempi-keho
rss-pt-paahtio
rss-kuumilla-aalloilla
rss-narsisti
meditaatiot-suomeksi
puhu-muru
selviytyjat-tarinoita-elamasta
terapiassa
junnut-pelissa
rss-nautinto
rss-en-saa-unta
fitnesskulmapodcast
rss-uplevel-by-sonja-hannus
rss-duodecim-lehti
rss-mighty-finland-podcast