328 | Mary Roach on Replacing Parts of Our Bodies

328 | Mary Roach on Replacing Parts of Our Bodies

Like any machine, bodies occasionally break down, and it's natural to go in search of a replacement part. Ancient societies featured simple prosthetics for teeth, noses, and limbs, while modern medicine pursues more advanced ways of replacing internal organs and microbiomes. But what is striking is not just the impressive ingenuity of our attempts to replicate human anatomy, but the surprising level of difficulty involved in doing it well. I talk with author Mary Roach about the many ways in which humans have chosen to replace bits of themselves, as told in her recent book Replaceable You: Adventures in Human Anatomy.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/09/15/328-mary-roach-on-replacing-parts-of-our-bodies/

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Mary Roach received a bachelor's degree in psychology from Wesleyan University. Her books include multiple New York Times bestsellers and have appeared on numerous best-of lists. She was a guest editor in the Best American Science and Nature Writing series, and received the Rushdie Award from the Harvard Secular Society.


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51 | Anthony Aguirre on Cosmology, Zen, Entropy, and Information

51 | Anthony Aguirre on Cosmology, Zen, Entropy, and Information

Cosmologists have a standard set of puzzles they think about: the nature of dark matter and dark energy, whether there was a period of inflation, the evolution of structure, and so on. But there are also even deeper questions, having to do with why there is a universe at all, and why the early universe had low entropy, that most working cosmologists don’t address. Today’s guest, Anthony Aguirre, is an exception. We talk about these deep issues, and how tackling them might lead to a very different way of thinking about our universe. At the end there’s an entertaining detour into AI and existential risk. Anthony Aguirre received his Ph.D. in Astronomy from Harvard University. He is currently associate professor of physics at the University of California, Santa Cruz, where his research involves cosmology, inflation, and fundamental questions in physics. His new book, Cosmological Koans, is an exploration of the principles of contemporary cosmology illustrated with short stories in the style of Zen Buddhism. He is the co-founder of the Foundational Questions Institute, the Future of Life Institute, and the prediction platform Metaculus. Web site UCSC web page Google Scholar page Wikipedia Amazon.com author page Foundational Questions Institute Future of Life Institute Metaculus Twitter See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Kesä 20191h 31min

50 | Patricia Churchland on Conscience, Morality, and the Brain

50 | Patricia Churchland on Conscience, Morality, and the Brain

It’s fun to spend time thinking about how other people should behave, but fortunately we also have an inner voice that keeps offering opinions about how we should behave ourselves: our conscience. Where did that come from? Today’s guest, Patricia Churchland, is a philosopher and neuroscientist, one of the founders of the subfield of “neurophilosophy.” We dig into the neuroscience of it all, especially how neurochemicals like oxytocin affect our attitudes and behaviors. But we also explore the philosophical ramifications of having a conscience, with an eye to understanding morality and ethics in a neurophilosophical context.   Support Mindscape on Patreon or Paypal. Patricia Churchland received her B.Phil. in philosophy from Oxford University. She is currently the President’s Professor of Philosophy (emerita) at the University of California, San Diego, as well as an adjunct professor of neuroscience at the Salk Institute. Among her awards are the MacArthur Prize, The Rossi Prize for Neuroscience and the Prose Prize for Science. Her latest book, Conscience: The Origins of Moral Intuition, was just released. She has arguably the best web site of any professional philosopher. Web site Google Scholar Amazon.com author page Wikipedia TEDx talk on The Brains Behind Morality Twitter See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Kesä 20191h 12min

49 | Nicholas Christakis on Humanity, Biology, and What Makes Us Good

49 | Nicholas Christakis on Humanity, Biology, and What Makes Us Good

It’s easy to be cynical about humanity’s present state and future prospects. But we have made it this far, and in some ways we’re doing better than we used to be. Today’s guest, Nicholas Christakis, is an interdisciplinary researcher who studies human nature from a variety of perspectives, including biological, historical, and philosophical. His most recent book is Blueprint: The Evolutionary Origins of a Good Society, in which he tries to pinpoint the common features of all human societies, something he dubs the “social suite.” Marshaling evidence from genetics to network theory to accounts of shipwreck survivors, he argues that we are ultimately wired to get along, despite the missteps we make along the way.   Support Mindscape on Patreon or Paypal. Nicholas Christakis received an M.D. from Harvard Medical School and a Ph.D. in Sociology from the University of Pennsylvania. He is currently Sterling Professor of Social and Natural Science in the Department of Sociology, with additional appointments in the Departments of Ecology and Evolutionary Biology; Statistics and Data Science; Biomedical Engineering; Medicine; and in the School of Management. He is a member of the Institute of Medicine of the National Academy of Sciences and a Fellow of the American Association for the Advancement of Science. Yale web page Google scholar page Amazon.com author page Wikipedia Twitter See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Kesä 20191h 54min

48 | Marq de Villiers on Hell and Damnation

48 | Marq de Villiers on Hell and Damnation

If you’re bad, we are taught, you go to Hell. Who in the world came up with that idea? Some will answer God, but for the purpose of today’s podcast discussion we’ll put that possibility aside and look into the human origins and history of the idea of Hell. Marq de Villiers is a writer and journalist who has authored a series of non-fiction books, many on science and the environment. In Hell & Damnation, he takes a detour to examine the manifold ways in which societies have imagined the afterlife. The idea of eternal punishment is widespread, but not quite universal; we might learn something about ourselves by asking where it came from.   Support Mindscape on Patreon or Paypal. Marq de Villiers was born in South Africa and now lives in Canada. He has worked as a reporter in a number of locations, from Cape Town to London to Moscow to Toronto. His books cover a variety of topics, many on history and ecology. He has been named a Member of the Order of Canada and awarded an honorary degree from Dalhousie University, among other accolades. Web site Amazon page Wikipedia Talk on the state of the world’s water See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Touko 20191h 11min

47 | Adam Rutherford on Humans, Animals, and Life in General

47 | Adam Rutherford on Humans, Animals, and Life in General

Most people in the modern world — and the vast majority of Mindscape listeners, I would imagine — agree that humans are part of the animal kingdom, and that all living animals evolved from a common ancestor. Nevertheless, there are ways in which we are unique; humans are the only animals that stress out over Game of Thrones (as far as I know). I talk with geneticist and science writer Adam Rutherford about what makes us human, and how we got that way, both biologically and culturally. One big takeaway lesson is that it’s harder to find firm distinctions than you might think; animals use language and tools and fire, and have way more inventive sex lives than we do. Adam Rutherford received his Ph.D. in genetics from University College London. He has written numerous books on genetics, evolution, synthetic biology, human history, and the origin of life. His most recent book is Humanimal: How Homo Sapiens Became Nature’s Most Paradoxical Creature — A New Evolutionary History. (Published in the UK with the more manageable title The Book of Humans: The Story of How We Became Us.) He frequently appears on and hosts science programs for the BBC on both radio and television, including Inside Science for BBC Radio 4. BBC Bio Page Articles at The Guardian Wikipedia Amazon.co.uk author page Talk on “What Makes Us Human” Twitter See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Touko 20191h 38min

46 | Kate Darling on Our Connections with Robots

46 | Kate Darling on Our Connections with Robots

Most of us have no trouble telling the difference between a robot and a living, feeling organism. Nevertheless, our brains often treat robots as if they were alive. We give them names, imagine that they have emotions and inner mental states, get mad at them when they do the wrong thing or feel bad for them when they seem to be in distress. Kate Darling is a research at the MIT Media Lab who specializes in social robotics, the interactions between humans and machines. We talk about why we cannot help but anthropomorphize even very non-human-appearing robots, and what that means for legal and social issues now and in the future, including robot companions and helpers in various forms. Support Mindscape on Patreon or Paypal. Kate Darling has a degree in law as well as a doctorate of sciences from ETH Zurich. She currently works at the Media Lab at MIT, where she conducts research in social robotics and serves as an advisor on intellectual property policy. She is an affiliate at the Harvard Berkman Klein Center for Internet & Society and at the Institute for Ethics and Emerging Technologies. Among her awards are the Mark T. Banner award in Intellectual Property from the American Bar Association. She is a contributing writer to Robohub and IEEE Spectrum. Web page Publications Twitter TED talk on why we have an emotional connection to robots See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Touko 20191h 6min

45 | Leonard Susskind on Quantum Information, Quantum Gravity, and Holography

45 | Leonard Susskind on Quantum Information, Quantum Gravity, and Holography

For decades now physicists have been struggling to reconcile two great ideas from a century ago: general relativity and quantum mechanics. We don’t yet know the final answer, but the journey has taken us to some amazing places. A leader in this quest has been Leonard Susskind, who has helped illuminate some of the most mind-blowing ideas in quantum gravity: the holographic principle, the string theory landscape, black-hole complementarity, and others. He has also become celebrated as a writer, speaker, and expositor of mind-blowing ideas. We talk about black holes, quantum mechanics, and the most exciting new directions in quantum gravity. Support Mindscape on Patreon or Paypal. Leonard Susskind received his Ph.D. in physics from Cornell University. He is currently the Felix Bloch Professor of Physics at Stanford University. He has made important contributions to numerous ideas in theoretical physics, including string theory, lattice gauge theory, dynamical symmetry breaking, the holographic principle, black hole complementarity, matrix theory, the cosmological multiverse, and quantum information. He is the author of several books, including a series of pedagogical physics texts called The Theoretical Minimum. Among his numerous awards are the J.J. Sakurai Prize and the Oskar Klein Medal. Web page Theoretical Minimum page Susskind Lectures on YouTube TED Talk about Richard Feynman Publications at Inspire Amazon author page Wikipedia See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Touko 20191h 13min

44 | Antonio Damasio on Feelings, Thoughts, and the Evolution of Humanity

44 | Antonio Damasio on Feelings, Thoughts, and the Evolution of Humanity

When we talk about the mind, we are constantly talking about consciousness and cognition. Antonio Damasio wants us to talk about our feelings. But it’s not in an effort to be more touchy-feely; Damasio, one of the world’s leading neuroscientists, believes that feelings generated by the body are a crucial part of how we achieve and maintain homeostasis, which in turn is a key driver in understanding who we are. His most recent book, The Strange Order of Things: Life, Feeling, and the Making of Cultures, is an ambitious attempt to trace the role of feelings and our biological impulses in the origin of life, the nature of consciousness, and our flourishing as social, cultural beings. Support Mindscape on Patreon or Paypal. Antonio Damasio received his M.D. and Ph.D. from the University of Lisbon, Portugal. He is currently University Professor, David Dornsife Professor of Neuroscience, Professor of Psychology, Professor of Philosophy, and (along with his wife and frequent collaborator, Prof. Hannah Damasio) Director of the Brain and Creativity Institute at the University of Southern California. He is also an adjunct professor at the Salk Institute in La Jolla, California. He is a member of the American Academy of Arts and Sciences, the National Academy of Medicine, and the European Academy of Sciences and Arts. Among his numerous awards are the Grawemeyer Award, the Honda Prize, the Prince of Asturias Award in Science and Technology, and the Beaumont Medal from the American Medical Association. USC web page Brain and Creativity Institute Google Scholar page Amazon.com author page Wikipedia TED talk on The Quest to Understand Consciousness Twitter See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Huhti 20191h 12min

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