If GLP-1 Drugs Are Good for Everything, Should We All Be on Them?

If GLP-1 Drugs Are Good for Everything, Should We All Be on Them?

To read more of Derek's reporting on GLP-1 drugs, you can subscribe to his Substack here. GLP-1 drugs like Ozempic and Zepbound don't just help with Type 2 diabetes and weight loss. They seem to curb alcohol, cocaine, and tobacco use among addicts. In some studies, they prevent strokes, heart attacks, chronic kidney disease, sleep apnea, and Parkinson's disease. They’re associated with a lower risk of several cancers, including pancreatic cancer and multiple myeloma. Arthritic patients on the drugs experienced relief from knee pain that was “on par with opioid drugs.” A small study found that they reduce migraine headaches by 50 percent. And emerging research suggests they might even slow the rate of memory loss among people diagnosed with Alzheimer’s. Is all of this real? And if it’s real, how is one drug doing so many different things? And if it is doing all those things, why shouldn’t we be developing versions of the drug for just about everyone? Today we have two guests: David D’Alessio, chief of endocrinology and metabolism at the Duke University School of Medicine; and Randy Seeley, a professor of surgery, internal medicine, and nutritional sciences at the University of Michigan. We talk about how these drugs work—why they seem to do everything—and how our understanding of them could make them better, more effective, more broadly useful. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guests: David D’Alessio and Randy Seeley Producer: Devon Baroldi Disclosure: Dr. Seeley has received research support from several pharmaceutical companies, including Eli Lilly, Diasome, and Amgen. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Why Everybody Is Wrong About a Recession and Housing’s Great Comeback

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If we’re being honest, the whole thing is kind of funny. A Chinese spy balloon floated across the U.S. Nobody died, unless we count the balloon itself. In a saner age, this story would be over. But ba...

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Econ Megapod: The Debt Ceiling Is Dumb, and the Inflation “Crisis” Might Be Over

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The Dark Side of Being Obsessed With Productivity

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"Productivity is a trap. Nobody in the history of humanity has ever achieved work-life balance. The real problem isn’t our limited time. The real problem—or so I hope to convince you—is that we’ve unw...

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How AI Could Change Apple and Google, Writing and Music, and Everything Else

How AI Could Change Apple and Google, Writing and Music, and Everything Else

“The story of 2022 was the emergence of AI," wrote Ben Thompson, the author of the Stratechery newsletter and podcast. "It seems clear to me that this is a new epoch in technology.” Ben and Derek talk...

27 Tammi 20231h 1min

Why Big Tech's Jobs Bubble Burst. Plus, SBF's Scandal Deepens.

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Derek breaks down the biggest economic mystery of the moment: Why are the most successful tech companies collectively laying off more than 130,000 people if the overall unemployment rate is still hist...

24 Tammi 202347min

America Isn’t Ready for the Weight-Loss-Drug Revolution That’s Coming

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We have historically thought about weight as the mere outcome of our deliberate choices about diet and exercise. We have not typically thought about weight like a disease. But in the past 18 months, t...

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